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Fibrin Sealant

Fibrin for Chronic Multi-level Discogenic Low Back Pain

Phase 2 & 3
Waitlist Available
Led By Kevin Pauza, MD
Research Sponsored by Pauza, Kevin, MD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* Recipient of Intra-annular fibrin injection for annular defects identified radographically and by annulogram
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up two years
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing if injecting a protein called fibrin into the spine can help people with serious chronic low back pain by repairing damaged tissues and reducing pain.

Eligible Conditions
  • Spinal Radiculopathy
  • Degenerative Disc Disease
  • Low Back Pain
  • Radiculopathy
  • Lower Back Pain
  • Disc Disease
  • Annular Disc Tear

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~two years
This trial's timeline: 3 weeks for screening, Varies for treatment, and two years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Oswestry Disability Index (ODI)
Secondary study objectives
EURO Quality of Life (EuroQol)
North American Spine Society (NASS) for patient satisfaction
Numeric Rating Scale (NRS)
+4 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Fibrin GroupExperimental Treatment1 Intervention
Experimental: Non-Autologuos Fibrin (NAF) Subjects in the NAF arm received an injection of non-autologous fibrin
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Fibrinogen human
FDA approved

Find a Location

Who is running the clinical trial?

Pauza, Kevin, MDLead Sponsor
Kevin Pauza, MDPrincipal InvestigatorINTERVENTIONAL SPINE SPECIALIST
~53 spots leftby Dec 2025
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