Green Tea, Quercetin + Chemotherapy for Prostate Cancer

Phase 1 & 2

Waitlist Available

Led By Piwen Wang, PhD

Research Sponsored by Charles Drew University of Medicine and Science

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Confirmed progressive disease with concurrent use of enzalutamide, apalutamide, darolutamide, and/or abiraterone acetate

Adequate bone marrow function (ANC more than 1500 cells/mm³, platelet count more than 100,000 cells/mm³)

Must not have

Any comorbid condition that would preclude the administration of docetaxel/prednisone

Prior treatment of chemotherapy and/or radiotherapy for metastatic disease

Timeline

Screening 3 weeks

Treatment Varies

Follow Up on the 1st day of cycle 1 (each cycle is 21 days, 3 cycles total) of the dose escalation study.

Summary

This trial aims to see if adding green tea and quercetin to standard chemotherapy can help in treating advanced prostate cancer. Researchers will compare this combination to a placebo to understand its effectiveness and safety.

Who is the study for?

This trial is for men with advanced prostate cancer that continues to grow despite hormone therapy. Participants must have metastatic castration-resistant prostate cancer and be suitable for docetaxel chemotherapy. Specific eligibility details are not provided, but typically include factors like age, health status, and prior treatments.

What is being tested?

The study tests if green tea and quercetin can boost the effectiveness of docetaxel chemotherapy in treating advanced prostate cancer. Patients will either receive a placebo or the natural product combination alongside their standard chemotherapy regimen.

What are the potential side effects?

While specific side effects aren't listed here, common ones from docetaxel include fatigue, nausea, hair loss, low blood cell counts increasing infection risk; green tea and quercetin may add minimal side effects.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

My cancer has worsened despite treatment with specific prostate cancer medications.

Select...

My blood tests show my bone marrow is working well.

Select...

I am willing to stop drinking tea and taking quercetin supplements except for those provided in the study.

Select...

My cancer progressed despite hormone therapy or surgery to lower hormones.

Select...

My liver function tests are within normal limits.

Select...

I am a man aged 18 or older.

Select...

I have been diagnosed with prostate cancer that has spread.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I do not have any health conditions that would prevent me from taking docetaxel/prednisone.

Select...

I have received chemotherapy or radiotherapy for cancer that has spread.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ on the 1st day of cycle 1 (each cycle is 21 days, 3 cycles total) of the dose escalation study.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~on the 1st day of cycle 1 (each cycle is 21 days, 3 cycles total) of the dose escalation study.

This trial's timeline: 3 weeks for screening, Varies for treatment, and on the 1st day of cycle 1 (each cycle is 21 days, 3 cycles total) of the dose escalation study. for reporting.