Spinal Cord Neuromodulation for Spinal Cord Injury

Recruiting in Palo Alto (17 mi)

Overseen ByDaniel C Lu, MD PhD

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Phase 1 & 2

Waitlist Available

Sponsor: University of California, Los Angeles

No Placebo Group

Approved in 3 jurisdictions

Trial Summary

What is the purpose of this trial?This study is designed to assess the strategy of using spinal cord stimulation to improve the ability to move in spinal cord injured humans.

Eligibility Criteria

This trial is for adults over 18 with non-progressive spinal cord injury above C5, at least one year post-injury. Participants should not have severe heart/lung diseases, ongoing depression or drug abuse, recent botox injections, or conditions that prevent arm movement. Pregnant women and those on anti-spasticity meds or involved in other trials are excluded.

Inclusion Criteria

I don't have bleeding disorders, heart risks, or major health issues for surgery.

My spinal cord injury is stable and located above the C5 vertebra.

My reflexes work below my spinal injury.

I am not pregnant and use birth control.

I do not have severe heart or lung diseases.

I am not currently taking any medication for muscle stiffness.

It has been over a year since my injury.

I don't have any unhealed injuries or infections in my arms that would affect training.

I am 18 years old or older.

My heart and lungs are healthy enough for me to move my hands and arms without issues.

I do not have severe heart or lung diseases.

I cannot grip or move on my own.

Participant Groups

The study tests whether spinal cord stimulation combined with a medication called Buspirone can improve movement in people with quadriplegia due to spinal cord injury. It aims to assess the effectiveness of this neuromodulation strategy.

1Treatment groups

Experimental Treatment

Group I: StimulationExperimental Treatment2 Interventions

Determine if epidural stimulation can improve motor function.

Epidural Stimulation is already approved in United States, Canada, European Union for the following indications:

🇺🇸 Approved in United States as Epidural Stimulation for: