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Anti-epileptic drug

Topiramate to Reduce Cocaine Dependence

Phase 2
Waitlist Available
Led By Bankole A. Johnson, DSc,MD.PhD
Research Sponsored by Bankole Johnson
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
All Individual Drugs Already Approved

Summary

Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Topiramate, a medication which lowers dopamine levels, may have the ability to diminish cocaine cravings in addicts. The purpose of this study is to determine the effectiveness of topiramate in reducing cocaine's rewarding effects in individuals addicted to cocaine.

Eligible Conditions
  • Cocaine Use Disorder
  • Cocaine Abuse

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Side effects data

From 2017 Phase 4 trial • 282 Patients • NCT02191579
31%
Paraesthesia
13%
Dizziness
13%
Fatigue
13%
Cognitive Disorder
13%
Nausea
11%
Decreased appetite
8%
Vision blurred
8%
Distubance in attention
7%
Sinusitis
6%
Depression
1%
Deep vein thrombosis
1%
Peripheral arterial occlusive disease
1%
Concussion
1%
Chronic obstructive pulmonary disease
1%
Nephrolithiasis
1%
Pneumonia
1%
Road traffic accident
1%
Dehydration
100%
80%
60%
40%
20%
0%
Study treatment Arm
Topiramate
BOTOX®

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: TopiramateExperimental Treatment1 Intervention
Group II: PlaceboPlacebo Group1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Topiramate
FDA approved

Find a Location

Who is running the clinical trial?

Bankole JohnsonLead Sponsor
8 Previous Clinical Trials
1,296 Total Patients Enrolled
National Institute on Drug Abuse (NIDA)NIH
2,607 Previous Clinical Trials
3,329,790 Total Patients Enrolled
Bankole A. Johnson, DSc,MD.PhDPrincipal InvestigatorUniversity of Virginia
~1 spots leftby Jan 2026
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