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Antiplatelet Agent

DAPT + Direct Oral AntiCoagulants (DOAC) for Heart Attack (APERITIF Trial)

Phase 3
Waitlist Available
Led By Etienne PUYMIRAT
Research Sponsored by Assistance Publique - Hôpitaux de Paris
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Summary

APERITIF is a prospective randomized open-label, blinded end-point (PROBE) trial, nested in the ongoing the "FRENCHIE" registry, a French multicenter prospective observational study granted by "ANR-RHU Grand Emprunt", in which all consecutive patients admitted within 48 hours after symptom onset in a cardiac Intensive Care Unit (ICU) for an acute myocardial infarction (AMI) are included (NCT04050956). Among them, eligible Patients for "APERITIF" will be randomized into two groups: Dual Anti-Platelet Therapy (DAPT) alone or DAPT plus rivaroxaban 2.5mg twice daily for 4 weeks, prescribed as soon as possible after admission and completion of the initial percutaneous coronary intervention/angiography procedure.

Eligible Conditions
  • Heart Attack
  • Left Ventricular Thrombus

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Rate of thrombus between the two arms
Secondary outcome measures
Description of the thrombus
Rate of antithrombotic using
Rate of bleeding events
+2 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: DAPT + Direct Oral AntiCoagulants (DOAC)Experimental Treatment2 Interventions
aspirin (≤100mg per day), clopidogrel (75mg per day) or ticagrelor (90mg twice daily) and rivaroxaban 2.5mg twice daily.
Group II: DAPTActive Control1 Intervention
aspirin (≤100mg per day) and P2Y12 inhibitors (i.e. clopidogrel 75mg per day or ticagrelor 90mg twice a day), as per current guidelines
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Rivaroxaban
FDA approved

Find a Location

Who is running the clinical trial?

Assistance Publique - Hôpitaux de ParisLead Sponsor
3,182 Previous Clinical Trials
56,889,499 Total Patients Enrolled
Etienne PUYMIRATPrincipal InvestigatorAssistance Publique - Hôpitaux de Paris
~149 spots leftby Aug 2025
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