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Porcine vs Bovine Collagen Dressings for Wound Healing
N/A
Recruiting
Led By Amy C Killeen, DDS, MS
Research Sponsored by University of Nebraska
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, three months
Awards & highlights
No Placebo-Only Group
Summary
This trial examines the effects of porcine and bovine collagen wound dressings on tooth extraction sites, measuring changes in soft tissue and bone density.
Who is the study for?
This trial is for adults aged 18-65 who need a front tooth or premolar extracted and grafted, are in good health overall, and don't smoke. They must be willing to consent to the study's procedures. People can't join if they've had radiation therapy or used bisphosphonates, are pregnant or breastfeeding, have conditions that affect bone healing, or can't make follow-up visits.
What is being tested?
The study aims to see which works better for healing after a tooth is pulled: a wound dressing made from pig collagen (porcine membrane) versus one from cow collagen (bovine dressing). It will look at changes in soft tissue thickness and bone density at the site of the extraction.
What are the potential side effects?
Possible side effects may include allergic reactions to either type of collagen dressing, irritation at the wound site, infection risk due to improper healing, and discomfort associated with any foreign material placed into an extraction site.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline, three months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, three months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Soft tissue thickness in mm
Secondary study objectives
Bone density in Hounsfield units
Interleukiin - 1beta, measured in pg/mL
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Porcine Collagen MembraneExperimental Treatment1 Intervention
Atraumatic tooth extraction with porcine collagen membrane placement
Group II: Bovine Collagen DressingActive Control1 Intervention
Atraumatic tooth extraction with bovine collagen dressing placement
Find a Location
Who is running the clinical trial?
University of NebraskaLead Sponsor
555 Previous Clinical Trials
1,145,362 Total Patients Enrolled
1 Trials studying Wound Healing
Amy C Killeen, DDS, MSPrincipal InvestigatorUniversity of Nebraska
3 Previous Clinical Trials
110 Total Patients Enrolled
1 Trials studying Wound Healing
Amy C Killeen, DDS,MSPrincipal InvestigatorUNMC College of Dentistry
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am between 18 and 65 years old and do not smoke.I have had radiation therapy or used bisphosphonates.I cannot attend follow-up visits.I have a health condition that affects how my bones heal.I am in good overall health.I need a front tooth or premolar pulled and the area prepared for future dental work.
Research Study Groups:
This trial has the following groups:- Group 1: Bovine Collagen Dressing
- Group 2: Porcine Collagen Membrane
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.