MAP Wound Matrix for Wound Healing
(MOSAIC Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new treatment to aid the healing of clean surgical wounds after skin cancer surgery. Researchers aim to determine if the Microporous Annealed Particle (MAP) Wound Matrix, a type of wound dressing, is safe and effective compared to a traditional hydrocolloid dressing. The trial targets individuals who have undergone Mohs surgery for non-melanoma skin cancer and have wounds between 1 cm and 4 cm wide. It is suitable for those who can attend follow-up visits and adhere to medical instructions. As an unphased trial, this study provides patients the chance to contribute to innovative wound care research.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial's Principal Investigator.
What prior data suggests that the Microporous Annealed Particle (MAP) Wound Matrix device is safe for use after skin cancer surgery?
Research has shown that the Microporous Annealed Particle (MAP) Wound Matrix is generally safe for people. Studies indicate that MAP creates a favorable environment for cell growth and movement, aiding in healing. The treatment has not been linked to major side effects, such as severe delays in wound healing or infections. This suggests it is well-tolerated when used on wounds after skin cancer surgery.12345
Why are researchers excited about this trial?
Researchers are excited about the Microporous Annealed Particle (MAP) Wound Matrix because it offers a unique approach to healing clean surgical wounds. Unlike traditional hydrocolloid dressings like DuoDerm, which primarily create a moist environment to aid healing, the MAP Wound Matrix is designed with a microporous structure that actively supports tissue regeneration and wound closure. This innovative design could potentially enhance the healing process by promoting more efficient cell migration and vascularization, which are crucial for faster, more effective wound recovery.
What evidence suggests that the MAP Wound Matrix device is effective for wound healing after skin cancer surgery?
Research has shown that the Microporous Annealed Particle (MAP) Wound Matrix, which participants in this trial may receive, can improve wound healing. In a study using pigs, MAP led to better healing results compared to treatments like Aquafor, a common method for keeping wounds moist. This suggests that MAP might help wounds close faster and more effectively. The MAP Wound Matrix features a special supportive structure that promotes new tissue growth, making it a promising option for wound care after skin cancer surgery. Another treatment option in this trial is the Hydrocolloid dressing (DuoDerm), which will also be applied to wounds following Mohs micrographic surgery.14678
Who Is on the Research Team?
Andrea Quach, BS
Principal Investigator
Tempo Therapeutics
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
The Microporous Annealed Particle (MAP) Wound Matrix or Hydrocolloid dressing is applied to the wound immediately following Mohs micrographic surgery
Follow-up
Participants are monitored for safety and effectiveness after treatment, including incidence of serious adverse device effects
What Are the Treatments Tested in This Trial?
Interventions
- MAP Wound Matrix
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
The Microporous Annealed Particle (MAP) Wound Matrix device will be topically applied to the wound immediately following Mohs micrographic surgery (MMS).
A hydrocolloid (DuoDerm) will be topically applied to the wound immediately following Mohs micrographic surgery.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Tempo Therapeutics
Lead Sponsor
Citations
Heparin Microislands in Microporous Annealed Particle ...
We present a new approach to growth factor presentation by incorporating heparin microislands, which are spatially isolated heparin-containing microparticles.
Safety of Microporous Annealed Particle (MAP) Wound ...
Incidence of serious adverse device effects (SADE) (including delays in wound healing and surgical site infections) in subjects treated with MAP Wound Matrix, ...
1470 A synthetic, flowable wound matrix that improves ...
In this work, we tested if MAP can improve healing in a porcine excisional wound model, compared to Aquafor (moist wound healing) and the leading decellularized ...
Wound management materials and technologies from ...
This review explores the progression of wound care, highlighting advanced biomaterials, emerging technologies, and the intricate process of transforming ...
MAP Scaffolds | Duke University - Segura Lab
MAP stands for Microporous Annealed Particles, and it's a biomaterial we invented with special properties that make it stand out in a class of its own.
Microporous annealed particle hydrogels in cell culture, tissue ...
MAP exhibits a well-organized microporous structure that creates an optimal environment for cell growth, facilitating cell attachment, movement, and ...
Microporous annealed particle hydrogels in cell culture, ...
Abstract: Microporous annealed particle (MAP) hydrogels consist of densely crosslinked and annealed hydrogel particles.
Exploration of biomaterial-tissue integration in ...
Microporous annealed particle (MAP) scaffolds are comprised of hydrogel microparticles with inter- and intra-particle cross-links that provide structure and ...
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