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Behavioural Intervention
Exercise MRI for Aortic Aneurysm
Cleveland, OH
N/A
Recruiting
Led By Deborah Kwon, MD
Research Sponsored by The Cleveland Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Pre-operative aneurysm patients imaged pre-operatively and at 12 months must be admitted at the CCF cardiothoracic services for elective surgery due to aortic aneurysms and must be 18 years or older
Healthy controls for baseline comparison must be 18 years or older with no history of cardiovascular disease, hypertension, diabetes, or hypercholesterolemia
Must not have
Healthy controls for baseline comparison excluded if using cardioprotective medication or have a bicuspid aortic valve diagnosed using MRI
Pre-operative aneurysm patients imaged pre-operatively and at 12 months excluded if they have traumatic aortic rupture
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 12 months
Awards & highlights
No Placebo-Only Group
Summary
This trial aims to use exercise Cardiac MRI to study how aortic aneurysm patients respond to physical activity. By comparing imaging data with biomechanical properties of the aortic tissue, the
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Who is the study for?
This trial is for patients with aortic aneurysm, specifically those who can safely undergo exercise and cardiac MRI (CMR) tests. The exact inclusion criteria are not provided, but typically participants should be stable enough to perform exercise under supervision.Check my eligibility
What is being tested?
The study uses exercise combined with Cardiac MRI to evaluate the effects of physical activity on the aorta's function and elasticity in patients with aortic aneurysm. It aims to establish safe levels of exercise by correlating CMR data with biomechanical properties of the aorta.See study design
What are the potential side effects?
While specific side effects are not listed for this type of non-invasive imaging study, potential risks may include discomfort during exercise or from lying still during MRI scans, as well as reactions to contrast agents if used.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am 18 or older and need elective surgery for an aortic aneurysm at CCF.
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I am over 18 and have no history of heart disease, high blood pressure, diabetes, or high cholesterol.
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I am over 18, have an aneurysm that hasn't been operated on, and no past surgery for it.
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Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I am not on heart-protecting meds and do not have a two-flap aortic valve.
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I am being treated for an aneurysm and haven't had a traumatic aortic rupture.
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Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 12 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 12 months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Arterial Compliance
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
3Treatment groups
Experimental Treatment
Group I: Pre-operative Aneurysm PatientsExperimental Treatment1 Intervention
Exercise MRI
Group II: Healthy ControlsExperimental Treatment1 Intervention
Exercise MRI
Group III: Aneurysm Being MonitoredExperimental Treatment1 Intervention
Exercise MRI
Find a Location
Closest Location:Cleveland Clinic· Cleveland, OH
Who is running the clinical trial?
The Cleveland ClinicLead Sponsor
1,069 Previous Clinical Trials
1,376,963 Total Patients Enrolled
5 Trials studying Aortic Aneurysm
2,988 Patients Enrolled for Aortic Aneurysm
Deborah Kwon, MDPrincipal InvestigatorThe Cleveland Clinic
2 Previous Clinical Trials
560 Total Patients Enrolled