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Corticosteroid

Dexamethasone for Chronic Pain After Thoracic Surgery

N/A
Recruiting
Led By Veronique Brulotte, MD, Msc
Research Sponsored by Maisonneuve-Rosemont Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18-75 years old
Elective thoracic surgery using a thoracotomy incision and thoracic epidural analgesia
Must not have
Contra-indication to thoracic epidural analgesia
Patients already taking cortisone or dexamethasone
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
All Individual Drugs Already Approved
Approved for 60 Other Conditions

Summary

This trial looks at whether dexamethasone can help reduce post-operative pain in those who have had thoracic surgery.

Who is the study for?
This trial is for adults aged 18-75 who are scheduled for elective thoracic surgery with a specific type of incision and pain relief method. It's not open to those already on cortisone or dexamethasone, anyone refusing participation, patients with conditions that don't allow the planned pain relief approach, or those on long-term opioid treatment.
What is being tested?
The study tests if Dexamethasone given before surgery can reduce chronic post-surgery pain by tackling inflammation. Patients will either receive this drug or a saline solution as a comparison. The main goal is to see if there's less pain three months after thoracic surgery.
What are the potential side effects?
Dexamethasone may cause side effects like increased blood sugar levels, mood changes, higher risk of infection due to immune suppression, stomach ulcers, insomnia and possibly others related to its anti-inflammatory action.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 75 years old.
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I am scheduled for chest surgery with a specific type of cut and pain management.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I cannot have an epidural in my upper back due to health reasons.
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I am currently taking cortisone or dexamethasone.
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I have chosen not to participate in the trial.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Side effects data

From 2013 Phase 4 trial • 122 Patients • NCT01474915
2%
Deep Vein Thrombosis
2%
Cerebrospinal fluid leak
2%
Fever
100%
80%
60%
40%
20%
0%
Study treatment Arm
Ondansetron
Aprepitant

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 60 Other Conditions
This treatment demonstrated efficacy for 60 other conditions.

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: dexamethasone 10 mgExperimental Treatment1 Intervention
Dexamethasone 10 mg will be given as a single-dose, pre incision, intravenously
Group II: normal salinePlacebo Group1 Intervention
Patients in this group will receive 2.5 mL of normal saline intravenously, pre-incision
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Dexamethasone
FDA approved

Find a Location

Who is running the clinical trial?

Maisonneuve-Rosemont HospitalLead Sponsor
101 Previous Clinical Trials
38,267 Total Patients Enrolled
3 Trials studying Chronic Pain
723 Patients Enrolled for Chronic Pain
Veronique Brulotte, MD, MscPrincipal InvestigatorMaisonneuve-Rosemont Hospital

Media Library

Dexamethasone (Corticosteroid) Clinical Trial Eligibility Overview. Trial Name: NCT02112864 — N/A
Chronic Pain Research Study Groups: normal saline, dexamethasone 10 mg
Chronic Pain Clinical Trial 2023: Dexamethasone Highlights & Side Effects. Trial Name: NCT02112864 — N/A
Dexamethasone (Corticosteroid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02112864 — N/A
~5 spots leftby Dec 2025
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