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Non-invasive Brain Stimulation

Brain Stimulation for Dyslexia

N/A
Recruiting
Led By Katherine S. Aboud, PhD
Research Sponsored by Vanderbilt University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Right-handed native English monolingual speakers
Age range of subjects: minimum 18 years, maximum 40 years
Must not have
Any known neurologic pathology, including epilepsy, spina bifida, cerebral palsy, traumatic brain injury, and brain tumors
History of syncope
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to 12 month

Summary

This trial will test a new brain stimulation protocol to see if it can help improve reading ability in adults with low literacy levels. If successful, this could change how we treat low adult literacy and have impacts on other clinical disorders.

Who is the study for?
This trial is for right-handed, native English-speaking adults aged 18-40 with dyslexia. Participants must not have a low IQ, developmental disorders, visual or hearing impairments that can't be corrected, metal devices in their body, recent migraines, severe fatigue or psychiatric issues. They should not be pregnant and mustn't take certain medications.
What is being tested?
The study tests the effect of non-invasive brain stimulation on reading comprehension in adults with dyslexia. It compares different types of stimulations (RLN and CCN) against a sham intervention to see which improves reading skills and brain function.
What are the potential side effects?
While the description doesn’t specify side effects, non-invasive brain stimulation may cause discomfort at the stimulation site, headache, lightheadedness or seizures in rare cases.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am right-handed and only speak English.
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I am between 18 and 40 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have a known neurological condition such as epilepsy or brain injury.
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I have a history of fainting.
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I am on medication that can cause strokes or seizures.
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My IQ is below 70.
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I experience severe tiredness.
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I am taking medication that could affect my mood or increase my risk of seizures or strokes.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to 12 month
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 12 month for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in reading comprehension ability on standardized test measure
Performance in reading comprehension ability on test measure during stimulation session
Secondary study objectives
Change in brain activations during reading

Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: Reading and Language Network (RLN)Experimental Treatment1 Intervention
Participants receiving real stimulation to the left angular gyrus and left temporal pole.
Group II: RLN and CCNExperimental Treatment1 Intervention
Participants receiving real stimulation to the left dorsolateral prefrontal cortex and left angular gyrus.
Group III: Cognitive Control Network (CCN)Experimental Treatment1 Intervention
Participants receiving real stimulation to the bilateral dorsolateral prefrontal cortices.
Group IV: Sham stimulationPlacebo Group1 Intervention
Participants receiving sham stimulation.

Find a Location

Who is running the clinical trial?

Vanderbilt UniversityLead Sponsor
710 Previous Clinical Trials
6,143,155 Total Patients Enrolled
4 Trials studying Dyslexia
1,144 Patients Enrolled for Dyslexia
National Institutes of Health (NIH)NIH
2,818 Previous Clinical Trials
8,161,470 Total Patients Enrolled
1 Trials studying Dyslexia
28 Patients Enrolled for Dyslexia
Katherine S. Aboud, PhDPrincipal InvestigatorVanderbilt University

Media Library

Dyslexia Clinical Trial 2023: CCN real non-invasive brain stimulation intervention Highlights & Side Effects. Trial Name: NCT05523505 — N/A
~61 spots leftby Aug 2025
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