Positive Psychology Intervention for Blood Cancer Survivors
(PATH-3 Trial)

Recruiting in Palo Alto (17 mi)

Overseen byHermioni Amonoo, MD, MPP, MPH

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Brigham and Women's Hospital

No Placebo Group

Trial Summary

What is the purpose of this trial?

The main purpose of this research study is to determine if a positive psychology-based program in people who have received a stem cell transplant for blood cancer treatment is feasible and acceptable, and can help improve positive feelings, mood, quality of life, overall wellbeing and health. The Positive psychology for Allogenic Transplantation of Hematopoietic stem cell intervention (PATH), a novel 9-week phone-administered Positive psychological intervention (PPI).

Research Team

Hermioni Amonoo, MD, MPP, MPH

Principal Investigator

Brigham and Women's Hospital

Eligibility Criteria

Adults over 18 who have had a stem cell transplant for blood cancer at Dana Farber Cancer Institute and are nearing their 100-day post-transplant mark. Participants must be able to communicate in English and have access to a phone. Those with cognitive deficits, certain medical conditions, outpatient HSCT, or psychiatric issues that affect compliance are excluded.

Inclusion Criteria

Ability to speak, read and write English

I am an adult who had a bone marrow transplant at Dana Farber and am nearing 100 days post-transplant.

Access to a telephone

Exclusion Criteria

I am receiving a stem cell transplant for a non-cancerous blood condition.

I can understand and make decisions about participating in this study.

I am receiving a stem cell transplant as an outpatient.

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Treatment Details

Interventions

Positive Psychology Intervention (Behavioral Intervention)

Trial OverviewThe trial is testing the PATH program—a positive psychology intervention delivered by phone over nine weeks—to see if it can boost mood, quality of life, and overall health after allogeneic hematopoietic stem cell transplantation.

Participant Groups

2Treatment groups

Experimental Treatment

Active Control

Group I: PATH InterventionExperimental Treatment1 Intervention

Participants in the PATH Intervention arm will receive psychosocial support phone calls during week 1 through 9 following enrollment. At approximately 100-days post-HSCT, participants will begin an 9-week positive psychology program involving weekly calls with an interventionist and exercises (i.e., writing a letter of gratitude, identifying personal strengths, planning meaningful and enjoyable activities). -Self-assessment questionnaires to measure positive affect, health behaviors, and overall function before and after completing the Positive Psychology Intervention.

Group II: Usual Care ControlActive Control1 Intervention

Participants in the Usual Care Control arm will receive regular social work assessments as part of HSCT recovery and work does not focus on PPWB skill building or cognitive strategies.