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Exercise Preconditioning to Protect Against Dialysis-induced Cardiac Injury

N/A

Waitlist Available

Led By Christopher McIntyre

Research Sponsored by Lawson Health Research Institute

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

* must be on chronic hemodialysis for at least 3 months

* age 18 years or older

Timeline

Screening 3 weeks

Treatment Varies

Follow Up week 1 to week 4

Awards & highlights

No Placebo-Only Group

Summary

The goal of this study is to determine what happens to the heart muscle contraction when people cycle before their hemodialysis treatment. Will pre-dialysis exercise protect the heart from a decrease in pumping of the heart muscle (called stunning) that can happen during hemodialysis. We will study whether pre-dialysis exercise decreases heart stunning, decreases the number and severity of symptoms commonly associated with hemodialysis, and other outcomes

Eligible Conditions

Hemodialysis
Cardioprotection

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ week 1 to week 4

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~week 1 to week 4

This trial's timeline: 3 weeks for screening, Varies for treatment, and week 1 to week 4 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in the number of left ventricular segments undergoing a greater than 20% reduction in longitudinal strain as detected by echocardiogram

Secondary study objectives

Evaluate potential targets of preconditioning by exercise-induced cardio protection by focusing on hemodynamics (Blood Pressure)

Evaluate potential targets of preconditioning by exercise-induced cardio protection focusing on hemodynamics (CV Insight Monitoring)

Evaluate potential targets of preconditioning by exercise-induced cardio protection, focusing on blood markers

+4 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Randomization Order 2Experimental Treatment1 Intervention

Participants will be randomized into one of the two groups indicating the order in which they will receive the exercise intervention. Randomization Order 2 will receive the exercise treatment on the first day of the fourth week of the study. The other three days without exercise will consist of standard dialysis sessions with study procedures.

Group II: Randomization Order 1Experimental Treatment1 Intervention

Participants will be randomized into one of the two groups indicating the order in which they will receive the exercise intervention. Randomization Order 1 will receive the exercise treatment on the first day of the first week of the study. The other three days without exercise will consist of standard dialysis sessions with study procedures.

0 / 4Eligibility criteria met