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Antibiotic Resistant Patterns of Conjunctival and Nasophayngeal Flora After Repeated Exposure to Topical Antibiotics (ARCaNE Trial)

Nashville, TN
N/A
Waitlist Available
Led By Stephen J Kim, MD
Research Sponsored by Vanderbilt University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* age greater than 18 with choroidal neovascularization with planned treatment with intravitreal injections
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

Repeated exposure to topical antibiotics may alter the normal bacteria on the eye and in the nose and increase rates of resistance. This study will determine whether repeated short-term exposure to topical antibiotic drops which are commonly prescribed after eye injections to reduce the chance of infection increase rates of resistant bacteria which are normally found on the eye and in the nose. We hypothesis that certain commercially available antibiotics may increase rates of bacteria resistance more so than others.

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Eligible Conditions
  • Macular Degeneration

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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* age greater than 18 with choroidal neovascularization with planned treatment with intravitreal injections

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

4Treatment groups
Experimental Treatment
Group I: 4Experimental Treatment1 Intervention
Patients randomized to azithromycin (AzaSite)
Group II: 3Experimental Treatment1 Intervention
Patients randomized to ofloxacin (Ocuflox)
Group III: 2Experimental Treatment1 Intervention
Patients randomized to moxifloxacin (Vigamox)
Group IV: 1Experimental Treatment1 Intervention
Patients randomized to gatifloxacin (Zymar)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Conjunctival and nasopharyngeal bacteria cultures
2009
N/A
~30

Find a Location

Closest Location:Vanderbilt Eye Institute· Nashville, TN· 620 miles

Who is running the clinical trial?

Vanderbilt UniversityLead Sponsor
713 Previous Clinical Trials
6,142,680 Total Patients Enrolled
1 Trials studying Macular Degeneration
143 Patients Enrolled for Macular Degeneration
Stephen J Kim, MDPrincipal InvestigatorVanderbilt University Department of Ophthalmology
7 Previous Clinical Trials
355 Total Patients Enrolled
~1 spots leftby Mar 2026