Proton Beam Radiotherapy for Brain Cancer

Recruiting in Palo Alto (17 mi)

+1 other location

Overseen byTorunn Yock, MD

Age: < 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Massachusetts General Hospital

No Placebo Group

Approved in 4 Jurisdictions

Trial Summary

What is the purpose of this trial?There are two types of external radiation treatments (proton beam and photon beam). As part of the participant's treatment, they will receive radiation to the entire central nervous system (CNS); this is known as craniospinal irradiation (CSI). In the past, photon radiation therapy has been used for CSI. In this study we will be examining the effects of proton beam radiation therapy. Studies have suggested that this kind of radiation can cause less damage to normal tissue than photon radiation therapy. The physical characteristics of proton beam radiation let the doctor safely deliver the amount of radiation delivered to the tumor that is normally delivered through standard therapy but spare more normal tissue in the process.

Eligibility Criteria

This trial is for individuals aged 3-25 with a confirmed diagnosis of medulloblastoma or pineoblastoma, who have had surgery but no prior chemotherapy or radiation. They must start treatment within 35 days post-surgery and have a life expectancy over 3 months. Participants need adequate blood lab values and agree to use contraception.

Inclusion Criteria

Life expectancy of greater than 3 months

Blood laboratory values as outlined in the protocol

I have had a biopsy or surgery confirming I have medulloblastoma or pineoblastoma.

+4 more

Exclusion Criteria

I have undergone more than one chemotherapy treatment.

I have had radiation therapy before.

Any major uncontrolled or poorly controlled intercurrent illness that would limit compliance with study requirements

+2 more

Participant Groups

The study is examining proton beam radiation therapy as an alternative to the traditional photon beam therapy for brain tumors. It aims to see if proton beams can effectively target the tumor while sparing more healthy tissue due to its precise delivery method.

1Treatment groups

Experimental Treatment

Group I: Proton Beam RadiationExperimental Treatment1 Intervention

Proton Beam Radiation

Proton Beam Radiation is already approved in European Union, United States, Japan, Canada for the following indications:

🇪🇺 Approved in European Union as Proton Therapy for: