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Proton Beam Therapy

Proton Beam Radiotherapy for Brain Cancer

N/A
Waitlist Available
Led By Torunn I Yock, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Participants must have undergone biopsy or attempted surgical resection and must have histologically confirmed medulloblastoma or pineoblastoma
Age range between 3 and 25 at the time of enrollment
Must not have
Patients with more than one previous chemotherapy regimen
Patients with prior radiation therapy
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 years
Awards & highlights
No Placebo-Only Group

Summary

This trialexamines the effects of proton beam radiation therapy for CNS cancer, which has been suggested to cause less damage to normal tissue than traditional photon radiation therapy.

Who is the study for?
This trial is for individuals aged 3-25 with a confirmed diagnosis of medulloblastoma or pineoblastoma, who have had surgery but no prior chemotherapy or radiation. They must start treatment within 35 days post-surgery and have a life expectancy over 3 months. Participants need adequate blood lab values and agree to use contraception.
What is being tested?
The study is examining proton beam radiation therapy as an alternative to the traditional photon beam therapy for brain tumors. It aims to see if proton beams can effectively target the tumor while sparing more healthy tissue due to its precise delivery method.
What are the potential side effects?
Proton beam radiation may cause side effects similar to other forms of radiation like fatigue, skin reactions at the treatment site, headaches, hair loss, nausea, and potential long-term effects on growth and cognitive function.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have had a biopsy or surgery confirming I have medulloblastoma or pineoblastoma.
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I am between 3 and 25 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have undergone more than one chemotherapy treatment.
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I have had radiation therapy before.
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My cancer came back or got worse after chemotherapy before radiation.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Endocrine dysfunction
Neurocognitive Effects
Ototoxicity
Secondary study objectives
Acute toxicity
Progression Free Survival
Treatment efficiency

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Proton Beam RadiationExperimental Treatment1 Intervention
Proton Beam Radiation

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
3,012 Previous Clinical Trials
13,309,181 Total Patients Enrolled
1 Trials studying Medulloblastoma
59 Patients Enrolled for Medulloblastoma
M.D. Anderson Cancer CenterOTHER
3,066 Previous Clinical Trials
1,802,155 Total Patients Enrolled
4 Trials studying Medulloblastoma
36 Patients Enrolled for Medulloblastoma
National Cancer Institute (NCI)NIH
13,920 Previous Clinical Trials
41,016,844 Total Patients Enrolled
89 Trials studying Medulloblastoma
10,163 Patients Enrolled for Medulloblastoma

Media Library

Proton Beam Radiation (Proton Beam Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT01063114 — N/A
Medulloblastoma Research Study Groups: Proton Beam Radiation
Medulloblastoma Clinical Trial 2023: Proton Beam Radiation Highlights & Side Effects. Trial Name: NCT01063114 — N/A
Proton Beam Radiation (Proton Beam Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01063114 — N/A
~5 spots leftby Nov 2025
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