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Dietary Supplement

Hypercaloric diet enriched with carbohydrate food (7 days) for Lipid Disorder (AGL9 Trial)

N/A
Waitlist Available
Led By André Carpentier
Research Sponsored by Université de Sherbrooke
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Healthy subjects: subjects with normal glucose tolerance determined according to an oral glucose tolerance test and with a BMI above 25 kg/m2 without first degree of familial history of type 2 diabetes (parents, siblings).
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Summary

The present research protocol will analyze whether a short-term modification (one week) of dietary habits would have an impact on the postprandial metabolism of dietary fatty acids and on their uptake by non-adipose tissues, in healthy subjects. Each subject will participate in two protocols randomly determined and separated by a period of one month: a 7-day isocaloric diet (Protocol A) and a 7-day carbohydrate-rich diet containing +50% of the subject's energy needs. (Protocol B). At the end of each diet, the subject will go through a postprandial metabolic study of 8 hours where different parameters will be measured thanks to PET imaging and perfusions of stables isotopes.

Eligible Conditions
  • Lipid Disorder

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Ventricular Function
whole-body organ-specific Dietary Fatty Acid (DFA) partitioning
Secondary outcome measures
Anthropometric parameters
Cardiac DFA uptake
Cardiac and hepatic blood flow
+7 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Hypercaloric diet enriched with carbohydrate food (7 days)Experimental Treatment5 Interventions
Protocole B
Group II: Isocaloric diet (7 days)Placebo Group5 Interventions
Protocole A
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Hypercaloric diet
2015
N/A
~50
PET imaging
2005
Completed Phase 3
~670
Indirect calorimetry
2015
Completed Phase 4
~870

Find a Location

Who is running the clinical trial?

Hospices Civils de LyonOTHER
1,718 Previous Clinical Trials
3,306,376 Total Patients Enrolled
Université de SherbrookeLead Sponsor
302 Previous Clinical Trials
70,249 Total Patients Enrolled
André CarpentierPrincipal InvestigatorUniversité de Sherbrooke
2 Previous Clinical Trials
56 Total Patients Enrolled
~1 spots leftby Sep 2025