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Immersive Video Games for Cognitive Impairment (Quest-Tablet Trial)

N/A

Recruiting

Led By Peter E Wais, PhD

Research Sponsored by University of California, San Francisco

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline immediately before (t1) and post-assessment immediately after training regimen is completed (t2) providing for a composite score t2-t1

Summary

This trial shows promise for restoring memory capability in older adults and patients with cognitive impairment using immersive video games.

Who is the study for?

This trial is for older adults with memory issues or mild cognitive impairment. Participants must have good vision (with glasses if needed), be fluent in English, have completed at least 12 years of education, and be able to operate a response box. They should also be physically able to take brisk walks and not have conditions that make fMRI scans unsafe.

What is being tested?

The study tests whether immersive video games can improve memory by changing brain activity. It uses LabyrinthVR software and other similar tools compared against placebo games to see if they can help restore memory functions or provide therapeutic benefits.

What are the potential side effects?

Potential side effects may include discomfort with virtual reality experiences such as dizziness or nausea, especially for those who already experience vestibular or balance problems.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline immediately before training regimen begins

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline immediately before training regimen begins

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline immediately before training regimen begins for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

MDT change in mnemonic discrimination

TOUR change in recall

Task-based cortical functional connectivity associated with mnemonic discrimination capability and in control of sustained visual attention

+1 more

Secondary study objectives

Remote Cognitive Module (RCM)

Trial Design

4Treatment groups

Experimental Treatment

Placebo Group

Group I: LabyrinthVR ScootExperimental Treatment1 Intervention

Multi-session cognitive intervention with VIVE high-resolution head-mounted display virtual reality computer game that presents an adaptive spatial wayfinding challenge. Game movement via handheld controllers.

Group II: Labyrinth VR wirelessExperimental Treatment1 Intervention

Multi-session cognitive intervention with QUEST head-mounted display virtual reality computer game using wireless technology to present an adaptive spatial wayfinding challenge. Game movement via handheld controllers.

Group III: Labyrinth TabletExperimental Treatment1 Intervention

Multi-session cognitive intervention with tablet computer, displaying 2.5D version of Labyrinth game in an adaptive spatial wayfinding challenge. Game movement via on-screen control buttons.

Group IV: Placebo ControlsPlacebo Group1 Intervention

Multi-session cognitive intervention with handheld tablet or wireless virtual reality headset presentation of commercially available, narrative computer games.

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