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RAPID- Deceased Donor Transplant for Colorectal Cancer (CLEAR Trial)

N/A
Waitlist Available
Research Sponsored by Northwestern University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
- 1. All Patients of either gender ≥ 18 years of age who are listed for Liver transplant candidates at Northwestern with liver metastases due to colorectal cancer (CRLM).
2. Subjects must be able to provide informed consent themselves and without the use of a legally authorized representative (LAR), to be determined by the PI or Sub-I at the time of Consent
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months, 5 years and 10 years.
Awards & highlights
No Placebo-Only Group

Summary

Liver transplantation (LT) has become an accepted treatment for selected patients with unresectable liver metastases due to colorectal cancer (CRLM) but the scarcity of donor organs can create a difficult pathway to transplant for these patients. Resection And Partial Liver Transplantation With Delayed Total Hepatectomy (RAPID) is a described technique that combines staged liver resections with partial LT to enable LT in patients with CRLM.

Eligible Conditions
  • Colorectal Cancer
  • Liver Transplant

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months, 5 years and 10 years.
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months, 5 years and 10 years. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Graft and Patient Survival Outcomes
Secondary study objectives
Outcomes of liver transplant recipients

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Group I: RAPID- Deceased Donor TransplantExperimental Treatment1 Intervention
RAPID-Deceased Donor Transplant
Group II: RAPID Living Donor Liver TransplantExperimental Treatment1 Intervention
RAPID Living Donor Liver Transplant
Group III: Standard of Care/Conventional Living Donor Liver TransplantActive Control1 Intervention
Standard of Care/Conventional Living Donor Liver Transplant
Group IV: Standard of Care/Conventional Deceased Donor Whole Liver TransplantActive Control1 Intervention
Standard of Care/Conventional Deceased Donor Whole Liver Transplant

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Who is running the clinical trial?

Northwestern UniversityLead Sponsor
1,647 Previous Clinical Trials
958,572 Total Patients Enrolled
~53 spots leftby Jan 2034
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