Sleeve Gastrectomy vs Knee Replacement Surgery for Obesity

Recruiting in Palo Alto (17 mi)

+1 other location

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Memorial University of Newfoundland

No Placebo Group

Trial Summary

What is the purpose of this trial?The goal of this study is to determine whether undergoing bariatric surgery before knee replacement leads to better outcomes compared to undergoing knee replacement before bariatric surgery. Our secondary goal is to compare complication rates between these groups to determine if there is a difference based on the order of the two procedures. Participants will be randomly placed in one of two groups, with each undergoing both procedures but in opposite order. Quality of life will be assessed via questionnaires before and between each procedure, and rates of complications will also be documented to compare their rates between groups.

Eligibility Criteria

This trial is for adults with severe knee osteoarthritis and morbid obesity who haven't had bariatric surgery or knee replacement before. Participants should be fit enough for both surgeries. Those with other significant health issues, previous stomach or knee surgeries, or conditions affecting their ability to follow the study protocol are excluded.

Inclusion Criteria

My BMI is 35 or higher and I am on a waitlist for knee and weight loss surgery.

Exclusion Criteria

My health issues do not severely limit my daily activities.

History of significant mental illness

I have had surgery on my esophagus or stomach before.

+2 more

Participant Groups

The study aims to find out if it's better to have weight loss surgery (laparoscopic sleeve gastrectomy) before a knee replacement (total knee arthroplasty), or vice versa. Patients will be randomly assigned to one of two groups, each receiving the surgeries in a different order.

2Treatment groups

Active Control

Group I: Knee Arthroplasty then Sleeve GastrectomyActive Control2 Interventions

Participants in this arm will undergo total knee arthroplasty followed by laparoscopic sleeve gastrectomy at least 1 year following the first procedure.

Group II: Sleeve Gastrectomy then Knee ArthroplastyActive Control2 Interventions

Participants in this arm will undergo laparoscopic sleeve gastrectomy followed by a total knee arthroplasty at least 1 year following the first procedure.