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Prosthesis

Kinematic Analysis: Posterior Stabilized, Fixed Bearing Total Knee Arthroplasty With Attune Knee System

N/A
Waitlist Available
Led By William R Hamel, Ph. D.
Research Sponsored by The University of Tennessee, Knoxville
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 months post-operative
Awards & highlights
No Placebo-Only Group

Summary

A better understanding of knee joint kinematics is important to explain the premature polyethylene wear failures within total knee arthroplasties (TKAs) and to help design a prosthesis that most closely approximates the normal knee. Specifically, posterior stabilizing (PS) knees have been found to be associated with lower amounts of posterior femoral rollback, higher occurrence of reverse axial rotation and increased amount of condylar lift-off. The DePuy Synthes Joint Reconstruction's Attune PS fixed bearing (FB) knee system has incorporated subtle changes in its design to address restoration of kinematics that more closely resemble those of a normal knee. To understand if this design is able to effectively restore kinematics in the implanted knee, further in vivo analysis is necessary. This pilot study will analyze 5 subjects with the Attune PS FB 3 months post-operatively using the University of Tennessee's mobile fluoroscopy unit while performing three daily activities, level walking, ramp down and deep knee bend. Since this is a pilot study, there is no hypothesis.

Eligible Conditions
  • Osteoarthritis
  • Total Knee Replacement

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 months post-operative
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months post-operative for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Femoro-tibial Kinematics - Deep Knee Bend
Femoro-tibial Kinematics - Gait
Tibial Fractures
+3 more
Secondary study objectives
Max Ground Reaction Force - Deep Knee Bend
Max Ground Reaction Force - Gait
Max Ground Reaction Force - Ramp Down

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: DePuy Attune PS FB TKAExperimental Treatment1 Intervention
Individuals implanted with the DePuy Attune posterior stabilizing fixed bearing knee system implanted by a single surgeon at least three months post-operative.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
DePuy Attune posterior stabilizing fixed bearing knee system
2014
N/A
~40

Find a Location

Who is running the clinical trial?

DePuy OrthopaedicsIndustry Sponsor
80 Previous Clinical Trials
25,952 Total Patients Enrolled
45 Trials studying Osteoarthritis
11,026 Patients Enrolled for Osteoarthritis
The University of Tennessee, KnoxvilleLead Sponsor
90 Previous Clinical Trials
19,209 Total Patients Enrolled
7 Trials studying Osteoarthritis
288 Patients Enrolled for Osteoarthritis
William R Hamel, Ph. D.Principal InvestigatorUniversity of Tennessee
1 Previous Clinical Trials
30 Total Patients Enrolled
1 Trials studying Osteoarthritis
30 Patients Enrolled for Osteoarthritis
Adrija Sharma, Ph. D.Principal InvestigatorUniversity of Tennessee
1 Previous Clinical Trials
30 Total Patients Enrolled
1 Trials studying Osteoarthritis
30 Patients Enrolled for Osteoarthritis
~0 spots leftby Dec 2025