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Chelating Agent

Ancillary-Correlative (laboratory biomarker analysis) for Hodgkin's Lymphoma

N/A
Recruiting
Led By Eric J Chow
Research Sponsored by Children's Oncology Group
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from time of cancer treatment to subsequent follow-up
Awards & highlights

Summary

This clinical trial studies the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer treatment. Studying samples of blood in the laboratory from patients receiving dexrazoxane hydrochloride may help doctors learn more about the effects of dexrazoxane hydrochloride on cells. It may also help doctors understand how well patients respond to treatment.

Eligible Conditions
  • Hodgkin's Lymphoma
  • Leukemia
  • Malignant Neoplasm
  • Lymphoblastic Lymphoma
  • Osteosarcoma
  • Lymphoma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Differences in serum biomarkers (particularly cardiac troponins and natriuretic peptides)
Left ventricular function and measures of pathologic remodeling (i.e., thickness-to-dimension ratio) assessed using standard 2-dimensional, M-mode, and Doppler echocardiogram
Secondary outcome measures
Longitudinal trajectory of 2-dimensional echocardiographic parameters
Primary disease relapse
Quality of life based on self-report instruments
+1 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Ancillary-Correlative (laboratory biomarker analysis)Experimental Treatment4 Interventions
Patients complete a diagnostic symptom checklist, undergo a physical exam, echocardiogram, collection of serum for biomarker testing, and a 6 minute walk test, and complete quality of life, family history, physical activity, and smoking questionnaires.

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Who is running the clinical trial?

Children's Oncology GroupLead Sponsor
456 Previous Clinical Trials
239,367 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,748 Previous Clinical Trials
40,958,981 Total Patients Enrolled
Eric J ChowPrincipal InvestigatorChildren's Oncology Group
~37 spots leftby Sep 2025
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