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Treatment for Malignant Pleural Mesothelioma (BASECAMP-1 Trial)

N/A
Recruiting
Research Sponsored by A2 Biotherapeutics Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 2 years
Awards & highlights

Summary

Objective: To collect information on how often a solid tumor cancer might lose the Human Leukocyte Antigen (HLA) by next generation sequencing and perform apheresis to collect and store an eligible participant's own T cells for future use to make CAR T-Cell therapy for their disease treatment. Design: This is a non-interventional, observational study to evaluate participants with solid tumors with a high risk of relapse for incurable disease. No interventional therapy will be administered on this study. Some of the information regarding the participant's tumor analysis may be beneficial to management of their disease. Participants that meet all criteria may be enrolled and leukapheresed (blood cells collected). The participant's cells will be processed and stored for potential manufacture of CAR T-cell therapy upon relapse of their cancer.

Eligible Conditions
  • Malignant Pleural Mesothelioma
  • Solid Tumors
  • Ovarian Tumors
  • Non-Small Cell Lung Cancer
  • Ovarian Cancer
  • Colorectal Cancer
  • Pancreatic Cancer
  • Mesothelioma
  • Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percentage of participants who can enroll in an A2 Biotherapeutics, Inc. CAR T-cell therapy study after undergoing apheresis
Percentage of screened participants experiencing loss of heterozygosity (LOH) of HLA-A*02 identified by next generation sequencing
Secondary outcome measures
Percentage of enrolled participants who experience an adverse event (AE) related to apheresis

Find a Location

Who is running the clinical trial?

Tempus AIIndustry Sponsor
16 Previous Clinical Trials
17,704 Total Patients Enrolled
A2 Biotherapeutics Inc.Lead Sponsor
2 Previous Clinical Trials
390 Total Patients Enrolled
Tempus LabsIndustry Sponsor
16 Previous Clinical Trials
18,204 Total Patients Enrolled
~11 spots leftby Dec 2024