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Behavioural Intervention

Blood Flow Restriction Training for Parkinson's Disease

N/A

Waitlist Available

Led By Anjali Sivaramakrishnan, PhD, PT

Research Sponsored by The University of Texas Health Science Center at San Antonio

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

In Hoehn and Yahr stage 2-4

Males and females between the ages 40 - 85 with a diagnosis of idiopathic Parkinson's Disease (PD) consistent with the United Kingdom PD society brain bank criteria

Must not have

History of cardiovascular disease, uncontrolled hypertension (blood pressure ≥140/90 mmHg), orthostatic hypotension, deep-vein thrombosis, varicose veins, or rhabdomyolysis

History of other neurological disorders affecting the central nervous system such as stroke, multiple sclerosis, tumors, amyotrophic lateral sclerosis or muscle disease such as muscular dystrophy, myopathy

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline to14 weeks

Awards & highlights

Summary

This trial aims to investigate how limiting blood flow during balance exercises can potentially help alleviate symptoms of Parkinson's disease.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My Parkinson's disease is at a moderate to advanced stage.

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I am between 40-85 years old and have been diagnosed with Parkinson's Disease.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have a history of heart disease or uncontrolled high blood pressure.

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I have a history of neurological or muscle disorders like stroke or MS.

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I am pre-menopausal and not using birth control.

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I am planning to undergo major surgery within the next 2 months.

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I do not have uncontrolled diabetes, severe osteoporosis, or cognitive issues.

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My BMI is above 40, indicating I might have poorer muscle function and more pain.

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I had surgery on my legs or feet in the last 6 months.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline to14 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline to14 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to14 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Feasibility metric

Secondary study objectives

Ankle plantar flexor muscle strength

Balance Measure

Functional Mobility

+6 more

Trial Design

2Treatment groups

Experimental Treatment

Group I: IRT Only Control GroupExperimental Treatment1 Intervention

Instability Resistance Training only group. Participants will receive 2 sessions per week over 6 weeks.

Group II: BFR plus IRT GroupExperimental Treatment2 Interventions

Blood Flow Restriction plus Instability Resistance Training group. Participants will receive 2 sessions per week over 6 weeks.

0 / 9Eligibility criteria met

Find a Location

Who is running the clinical trial?

The University of Texas Health Science Center at San AntonioLead Sponsor

467 Previous Clinical Trials

91,744 Total Patients Enrolled

National Institute on Aging (NIA)NIH

1,733 Previous Clinical Trials

28,054,983 Total Patients Enrolled

Anjali Sivaramakrishnan, PhD, PTPrincipal InvestigatorThe University of Texas Health Science Center at San Antonio

~13 spots leftby Dec 2025

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