← Back to Search

Corticosteroid

PNS Therapy vs. Steroid Injections for Chronic Knee Pain

N/A
Recruiting
Led By Saba Javed, MD
Research Sponsored by M.D. Anderson Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years

Summary

This trial will compare the effects of steroid injections, PNS therapy with a steroid injection, and PNS therapy with a placebo injection on knee range of motion in patients with chronic knee pain.

Who is the study for?
This trial is for adults aged 18-85 with chronic knee pain, treated at the MD Anderson Cancer Center. Eligible participants must have a baseline pain score of 4 or higher and be able to consent. Those with opioid use unrelated to knee pain, cognitive issues, skin infections, recent substance abuse history, or allergies to local anesthetics or steroids cannot join.
What is being tested?
The study compares three treatments: a standard steroid injection into the knee; peripheral nerve stimulation (PNS) plus steroid injection; and PNS with a placebo. The goal is to see which method best improves knee movement in patients suffering from chronic knee pain.
What are the potential side effects?
Possible side effects include reactions at the injection site such as pain or infection for both steroid and placebo injections. PNS therapy might cause discomfort where the device attaches or temporary changes in skin sensation.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Trial Design

3Treatment groups
Experimental Treatment
Group I: Group 3 (PNS therapy plus 1 placebo injection)Experimental Treatment2 Interventions
Participants will receive PNS therapy plus 1 placebo injection.
Group II: Group 2 (PNS therapy plus 1 standard steroid injection).Experimental Treatment3 Interventions
Participants will receive PNS therapy plus 1 standard steroid injection.
Group III: Group 1 (standard steroid injection)Experimental Treatment2 Interventions
Participants will receive 1 standard steroid injection.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bupivacaine
2013
Completed Phase 4
~1530
Triamcinolone
2016
Completed Phase 4
~1220

Find a Location

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor
3,067 Previous Clinical Trials
1,802,564 Total Patients Enrolled
Saba Javed, MDPrincipal InvestigatorM.D. Anderson Cancer Center
1 Previous Clinical Trials
10 Total Patients Enrolled
~22 spots leftby Jan 2026
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top