~67 spots leftby Nov 2025

Clear Liquid Diet for Reducing Pulmonary Aspiration Risk

Recruiting in Palo Alto (17 mi)
Overseen bySudipta Sen, MD, FASA
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Waitlist Available
Sponsor: The University of Texas Health Science Center, Houston
No Placebo Group

Trial Summary

What is the purpose of this trial?

The purpose of this study is to determine if prolonged fasting from solids and transitioning to a CLD for 24 hours is protective to decrease RGC in patients on GLP-1 RAs presenting for upper endoscopy, to determine if prolonged fasting is associated with increased thirst, hunger and anxiety, To determine if signs and symptoms of nausea, vomiting, retching, abdominal bloating, and abdominal pain are present on the day of surgery, to see if there is any variability between preoperative gastric ultrasound assessment and volume of gastric contents visualized on upper endoscopy, to determine time of gastric emptying by serial Gastric ultrasonography (GUS) scans every 2 hours in subjects who presented with an initial at-risk scan, to determine the choice of anesthesia used based on preoperative GUS results, to determine if there were any adverse events recorded in this study group, to determine if duration of GLP-1 RA therapy has an association with residual gastric content (RGC). and to determine if dosing of GLP-1 RA has an association with RGC.

Eligibility Criteria

This trial is for patients on GLP-1 receptor agonists who are scheduled for upper endoscopy. They're looking at whether a clear liquid diet (CLD) for 24 hours before the procedure can help reduce stomach contents and improve safety during anesthesia.

Inclusion Criteria

I am currently taking GLP-1 receptor agonists.
I am scheduled for an upper endoscopy without a colonoscopy.

Exclusion Criteria

Gastric band in situ
Recent trauma
I have a history of delayed stomach emptying.
See 6 more

Treatment Details

Interventions

  • GLP-1 RA (GLP-1 Receptor Agonist)
Trial OverviewThe study tests if a clear liquid diet versus standard fasting protocols can lower residual gastric content in patients taking GLP-1 RA medications before receiving anesthesia. It also examines patient comfort, timing of gastric emptying, choice of anesthesia, and any adverse events.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Prolonged fastingExperimental Treatment1 Intervention
Group II: Standard nil per os (NPO)Active Control1 Intervention

Find a Clinic Near You

Research Locations NearbySelect from list below to view details:
The University of Texas Health Science Center at HoustonHouston, TX
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Who Is Running the Clinical Trial?

The University of Texas Health Science Center, HoustonLead Sponsor

References