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Magnetic Stimulation for Psychosis

N/A

Recruiting

Research Sponsored by Mclean Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age between 18-55 years

Diagnosis of a psychotic disorder (i.e. schizophrenia or schizoaffective disorder or bipolar disorder type I)

Must not have

History of fainting spells of unknown or undetermined etiology that might constitute seizures

Any progressive (e.g., neurodegenerative) neurological disorder such as multiple sclerosis or Parkinson's disease

Timeline

Screening 3 weeks

Treatment Varies

Follow Up eight minutes before tms and one minute after tms on each of the three tms visit days

Summary

This trial tests if magnetic stimulation can improve processing speed in people with psychotic disorders.

Who is the study for?

This trial is for adults aged 18-55 with a psychotic disorder (schizophrenia, schizoaffective disorder, or bipolar I). Participants must be stable outpatients who speak English and can complete study tasks. Exclusions include recent substance use disorders, certain brain conditions, metal implants not MRI-safe, pregnancy, seizure history, and progressive neurological diseases.

What is being tested?

The study tests if magnetic stimulation (iTBS/cTBS) affects cognitive processing speed in psychosis. Participants will do problem-solving tasks and have brain scans before/after transcranial magnetic stimulation (TMS), which temporarily alters brain activity.

What are the potential side effects?

While TMS is generally safe and FDA-approved for some conditions like depression and OCD, potential side effects may include discomfort at the stimulation site, headache, lightheadedness or seizures in very rare cases.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 55 years old.

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I have been diagnosed with schizophrenia, schizoaffective disorder, or bipolar disorder type I.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have had fainting spells that might be seizures.

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I have a worsening condition like multiple sclerosis or Parkinson's.

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I am experiencing symptoms of high pressure inside my skull.

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I have had a head injury that caused me to lose consciousness for more than 15 minutes.

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I have a brain condition due to genetics (like Neurofibromatosis) or an event (like a stroke).

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I don't have uncontrolled chronic conditions like heart issues or asthma.

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I have a tumor in my brain.

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I have had multiple seizures or have been diagnosed with epilepsy.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ eight minutes before tms and one minute after tms on each of the three tms visit days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~eight minutes before tms and one minute after tms on each of the three tms visit days

This trial's timeline: 3 weeks for screening, Varies for treatment, and eight minutes before tms and one minute after tms on each of the three tms visit days for reporting.