Laser Treatment for Scars and Scleroderma

Recruiting in Palo Alto (17 mi)

Overseen byDieter Manstein, MD, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Massachusetts General Hospital

No Placebo Group

Trial Summary

What is the purpose of this trial?

In this study, the investigators seek to evaluate the effects of a laser treatment on the redistribution/regeneration of collagen on the clinical, microscopic, and molecular profiles of hypertrophic scars and scleroderma.

Research Team

Dieter Manstein, MD, PhD

Principal Investigator

Massachusetts General Hospital

Eligibility Criteria

Adults over 18, willing to consent and follow study rules, in good health based on screening, who can read English. They must have a large hypertrophic scar or scleroderma lesions suitable for treatment. Pregnant individuals, recent trial participants, those using certain medications/treatments for scars/scleroderma, with allergies to anesthetics or taking high doses of anti-inflammatory/immunosuppressive drugs cannot join.

Inclusion Criteria

I have a large scar or two similar scars suitable for treatment.

Subject must be able to read and understand English

My gender and skin type do not limit my participation.

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Exclusion Criteria

I regularly take high doses of anti-inflammatory or immunosuppressive drugs.

I haven't used prescription meds or treatments on my scars/scleroderma in the last 3 months.

Clinically significant abnormal findings or conditions which might, in the opinion of the Investigator, interfere with study evaluations or pose a risk to subject safety during the study

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Treatment Details

Interventions

Laser Treatment (Procedure)

Trial OverviewThe study is testing how effective laser treatment is at improving the appearance and condition of hypertrophic scars and scleroderma by promoting collagen redistribution/regeneration. It will look at clinical outcomes as well as microscopic and molecular changes.

Participant Groups

2Treatment groups

Active Control

Group I: SclerodermaActive Control1 Intervention

The entire lesion will receive laser treatment.

Group II: ScarsActive Control1 Intervention

The entire hypertrophic scar will receive laser treatment only.