Probiotic
Probiotics for Long COVID Symptoms
This trial tests whether taking a probiotic called Lp299v can help people who have long-term symptoms after COVID-19. The probiotic aims to reduce inflammation and improve blood vessel function. Adults aged 18-89 with these symptoms will take the supplement for a period of time to see if it helps. Probiotics have shown benefits in a variety of diseases, including respiratory infections, and may be beneficial in the adjunctive treatment of COVID-19.
Behavioural Intervention
Broccoli Sprouts for Healthy Eating
This trial will study the effects of broccoli sprouts on the human body at a molecular and metabolic level. It will also look at the composition of the microbiome (the microorganisms that live in the gut).
Behavioural Intervention
Diet Intervention for Juvenile Arthritis
This trial aims to investigate whether a Mediterranean Diet-based diet can improve arthritis in children by studying its effects on the gut microbiome. Fifty-four participants will change their diet for 8 weeks, with the
Prebiotic
Prebiotics for PTSD and Liver Cirrhosis
"This trial investigates the relationship between PTSD, cirrhosis, and gut microbiome in Veterans. Patients with both PTSD and cirrhosis have greater cognitive impairment and changes in gut microbiome compared to those
Popular Filters
Trials for Crohn's Disease Patients
Behavioural Intervention
Fasting-Mimicking Diet for Inflammatory Bowel Disease-Related Depression
This trial is investigating the effects of a fasting mimicking diet on IBD patients who are suffering from symptoms of depression. The goal is to develop a safe and effective treatment to improve mental health in patients with IBD by targeting the gut microbiome through dietary interventions.
Microbiome Therapy
Fecal Microbiota Transplant for Clostridium Difficile and IBD
This trial will study the safety and effectiveness of Fecal Microbiota Transplants (FMT) in children with recurrent C. Difficile infections, with or without Inflammatory Bowel Disease (IBD). 454 pyrosequencing will be used to study the gut microbiota before and after transplantation.
Behavioural Intervention
Dietary Therapy for Crohn's Disease and Ulcerative Colitis
This trial tests two special diets to help people with active Crohn's Disease or Ulcerative Colitis. One diet is a liquid nutrient formula, and the other limits certain carbs. The goal is to see if these diets can improve gut health and reduce symptoms.
Probiotic
Probiotics for Inflammatory Bowel Disease
This trial is a single-site, randomized, double-blind, placebo-controlled trial of a probiotic supplement. The study will last 12 weeks and will compare the effects of the probiotic on the gut microbiome, metabolomic profile, and fatigue symptoms in patients with quiescent IBD.
Dietary Intervention
Diet-CD for Crohn's Disease During Pregnancy
This trial tests if a special diet during pregnancy can improve gut health in women with Crohn's disease and their babies. The goal is to create a healthier balance of gut bacteria, which may help reduce disease relapse in mothers and lower gut inflammation in babies. The study will collect various samples to analyze the effects of the diet.
Trials for Microbial Colonization Patients
Microbiota Transplant
Nasal Bacteria Transfer for Neonatal Infections
This trial will investigate if transferring nasal bacteria from parents to newborns can introduce the parents' bacteria into the newborns' microbiome and improve the diversity of bacteria in the newborns.
Microbiota Transplant
Nasal Microbiota Transplant for Preventing Newborn Infections
This trial is testing if transferring healthy bacteria from a parent's nose to their newborn's nose can help protect the baby from harmful bacteria. The study focuses on newborns at Johns Hopkins Hospital. By creating a healthy bacterial environment in the baby's nose, the researchers hope to reduce the risk of infections.
Selective Serotonin and Norepinephrine Reuptake Inhibitor
Microbiome Influence on Drug Metabolism
This trial will study how drugs are metabolized by the microbiome in humans, in parallel with preclinical studies. The investigators will be able to confirm the relevance of microbiome-derived metabolism in vivo, create microbiome-dependent PK profiles of the drugs, and establish methodology to capture the contribution of microbiome-derived metabolism to inter-individual variability in clinical drug PK profiles.
Behavioural Intervention
Mouthrinses for Oral Microbiome Health
This trial studies the effects of two mouthwashes on bacteria and 3 viruses in the mouth and gut. Participants will make 5 visits over 180 days, spending 2.5 hours in total. Fecal matter will be collected in some.
Trials With No Placebo
Behavioural Intervention
Fasting-Mimicking Diet for Inflammatory Bowel Disease-Related Depression
This trial is investigating the effects of a fasting mimicking diet on IBD patients who are suffering from symptoms of depression. The goal is to develop a safe and effective treatment to improve mental health in patients with IBD by targeting the gut microbiome through dietary interventions.
Behavioural Intervention
High-Fiber Diet for Satiety
This trial is testing a high fiber diet made from peas on overweight/obese adults and those with metabolic syndrome. The diet aims to slow nutrient absorption and produce substances in the gut that increase fullness and improve health. Pea fiber has been studied for its potential to improve weight control and metabolic health in overweight and obese adults.
Trials Offering Remuneration
Microbiota Transplant
Nasal Bacteria Transfer for Neonatal Infections
This trial will investigate if transferring nasal bacteria from parents to newborns can introduce the parents' bacteria into the newborns' microbiome and improve the diversity of bacteria in the newborns.
Microbiota Transplant
Nasal Microbiota Transplant for Preventing Newborn Infections
This trial is testing if transferring healthy bacteria from a parent's nose to their newborn's nose can help protect the baby from harmful bacteria. The study focuses on newborns at Johns Hopkins Hospital. By creating a healthy bacterial environment in the baby's nose, the researchers hope to reduce the risk of infections.
Probiotic
Vaginal Seeding for Cesarean-Delivered Infants
This trial will test whether or not exposing infants to their mother's vaginal flora via 'vaginal seeding' has any health benefits. Infants will be followed for three years to see if there are any differences in microbiome development, immune development, metabolism, or adverse events.
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Frequently Asked Questions
Introduction to microbiome
What are the top hospitals conducting microbiome research?
The field of microbiome research is rapidly expanding, and top hospitals around the world are joining the pursuit of unraveling its mysteries. In New york City, the Icahn School of Medicine at Mount Sinai is leading the way with three active clinical trials focused on understanding the intricate world of microbes within our bodies. This esteemed institution's dedication to exploring this relatively uncharted territory highlights their commitment to cutting-edge medical science. Similarly, in Sacramento, Integrative Skin Science and Research is making significant contributions with three ongoing microbiome trials. Located in sunny California, this hospital brings a unique perspective to understanding how our skin interacts with microorganisms and its impact on overall health.
Northward in Calgary, Canada, researchers at the University of Calgary are also delving into the fascinating realm of microbiomes through their own set of three active clinical trials. As one might expect from a Canadian institution known for its picturesque landscapes and love for nature, they aim to shed light on how environmental factors influence our microbial communities.
Across the Atlantic Ocean lies Birmingham's University of Alabama at Birmingham (UAB), where scientists have embraced studying microbiomes as well. With three current clinical trials underway at UAB, researchers there are dedicated to uncovering how these little-known ecosystems affect human health and disease management strategies.
Meanwhile,iIn Baltimore's prestigious Johns Hopkins University,a revered name worldwide when it comes to medical breakthroughs,two active microbiome trials demonstrate that even institutions renowned for other areas can be partakers in advancing this frontier.Contributions from various experts across different locations not only enriches professional knowledge but also underlines global significance surrounding better comprehension about benefits derived within human body ecosystem itself
These leading hospitals' efforts symbolize an exciting era in healthcare where we realize just how much impact tiny organisms can have on our well-being. By investigating these complex microbial communities residing within us - whether it be inside our organs or on our skin - researchers strive towards improving treatments and interventions that harness the power of our microbiomes for optimal health.
Which are the best cities for microbiome clinical trials?
Chicago, Illinois; New york, New York; Boston, Massachusetts; Sacramento, California; and Houston, Texas emerge as the top cities for microbiome clinical trials. These cities host several active studies that investigate various aspects of the microbiome and its impact on health. From gluten challenges and special diets to stem cell grafts and fecal microbiota transplantation, these trials offer a breadth of research opportunities aimed at unraveling the mysteries of the human microbiome. With innovative interventions being explored in these diverse locations across the United States, individuals have access to cutting-edge investigations that may pave the way for novel treatments and improved understanding of this fascinating field.
Which are the top treatments for microbiome being explored in clinical trials?
The microbiome field is abuzz with ongoing clinical trials, investigating various treatments that hold promise in harnessing the power of our microbial partners. Leading the charge are fecal microbiota transplantation (FMT) and next-generation probiotics. FMT, involving the transfer of healthy donor stool to restore a balanced gut ecosystem, is being explored in multiple trials across different conditions. Next-generation probiotics utilize advanced techniques to develop tailored bacterial strains for targeted therapeutic interventions. These innovative approaches have captured significant attention and continue to drive research efforts towards unlocking the potential of the human microbiome.
What are the most recent clinical trials for microbiome?
Exciting advancements in microbiome research are taking place through recent clinical trials. These trials include an interventional study aimed at understanding the impact of various interventions on the microbiome, a phase 2 trial exploring the potential benefits of THC on the microbiome, and a phase 4 trial investigating Omadacycline Injection's effects on this complex ecosystem. Additionally, there is a ongoing phase 2 trial evaluating a drug product specifically designed to target and modulate the microbiome. Finally, another intriguing study focuses on Metformin's potential role in influencing microbial communities within our bodies. As these clinical trials progress, they hold promise for expanding our knowledge and developing innovative approaches to harnessing the power of the microbiome for better health outcomes.
What microbiome clinical trials were recently completed?
Several microbiome clinical trials have recently concluded, providing valuable insights into this emerging field of research. These studies shed light on the complex relationship between our microbial communities and human health. While it is important to note that there were multiple trials completed, a noteworthy example includes a trial sponsored by the University of California investigating the effects of fecal microbiota transplantation in patients with recurrent Clostridium difficile infection. By focusing on these key investigations, we can gain a deeper understanding of how manipulating the microbiome may hold potential for future therapeutic interventions.