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Mouthrinses for Oral Microbiome Health (Microbiome Trial)

N/A
Recruiting
Led By Dr. Petra Wilder-Smith
Research Sponsored by University of California, Irvine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 180

Summary

This trial studies the effects of two mouthwashes on bacteria and 3 viruses in the mouth and gut. Participants will make 5 visits over 180 days, spending 2.5 hours in total. Fecal matter will be collected in some.

Who is the study for?
This trial is for healthy individuals aged 18-25 with either good gum health or gums that bleed when brushing. Participants must have at least 20 teeth, not be on antibiotics in the last 3 months, and agree to attend all study visits and procedures.
What is being tested?
The study tests how Listerine mouthwash and Lumineux Oral Essentials affect oral and gut bacteria plus three types of viruses. Participants will use one of these rinses or water twice daily for about six months, with five check-in visits.
What are the potential side effects?
Potential side effects may include changes in taste sensation, dryness or irritation inside the mouth, allergic reactions to ingredients in the mouthwashes, or an imbalance in oral/gut microbiome.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 180
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 180 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
total bacterial load and mRNA analysis
viral load and mRNA analysis using RT-PCR

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Lumineux Oral Essentials rinseExperimental Treatment1 Intervention
rinse twice daily for 1 min with Lumineux Oral Essentials rinse
Group II: Listerine rinseExperimental Treatment1 Intervention
rinse twice daily for 1 min with Listerine rinse
Group III: Water rinsePlacebo Group2 Interventions
rinse twice daily for 1 min with water

Find a Location

Who is running the clinical trial?

University of California, IrvineLead Sponsor
564 Previous Clinical Trials
1,932,396 Total Patients Enrolled
Dr. Petra Wilder-SmithPrincipal InvestigatorBeckman Laser Institute University of California Irvine
1 Previous Clinical Trials
275 Total Patients Enrolled
Petra Wilder-Smith, DDS, PhDPrincipal InvestigatorUniversity of Calfornia Irvine
2 Previous Clinical Trials
2,577 Total Patients Enrolled

Media Library

Listerine rinse Clinical Trial Eligibility Overview. Trial Name: NCT05603650 — N/A
Viral Infections Research Study Groups: Listerine rinse, Water rinse, Lumineux Oral Essentials rinse
Viral Infections Clinical Trial 2023: Listerine rinse Highlights & Side Effects. Trial Name: NCT05603650 — N/A
Listerine rinse 2023 Treatment Timeline for Medical Study. Trial Name: NCT05603650 — N/A
~96 spots leftby Dec 2027
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