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Latuda vs Geodon
Introduction
For patients with bipolar disorder, schizophrenia or other types of psychotic disorders, certain drugs that alter the concentrations of compounds in the brain linked to mood and perception can help in managing symptoms. Latuda and Geodon are two such medications prescribed for these conditions. They each impact different neurotransmitters in the brain but both have effects on stabilizing moods and treating psychosis. Latuda is a serotonin-dopamine antagonist (SDA), influencing levels of serotonin and dopamine by blocking their respective receptors. On the other hand, Geodon is classified as an atypical antipsychotic also known as a second-generation antipsychotic (SGA). It works primarily by affecting levels of serotonin and dopamine but its exact mechanism isn't fully understood.
Latuda vs Geodon Side By Side
| Attribute | Latuda | Geodon |
|---|---|---|
| Brand Name | Latuda | Geodon |
| Contraindications | May exacerbate symptoms of depression, increase suicidal thoughts or behaviors, should not be taken with Class 1A or Class III antiarrhythmics. | May exacerbate symptoms of depression, increase suicidal thoughts or behaviors, should not be taken with Class 1A or Class III antiarrhythmics. |
| Cost | For brand name: around $1400 for 30 tablets of 40 mg. For generic (lurasidone): ranges from $1 to over $3 per day. | For brand name: about $600 for 60 capsules of 20 mg. For generic (ziprasidone): starts from under a dollar per day up to around two dollars daily. |
| Generic Name | Lurasidone | Ziprasidone |
| Most Serious Side Effect | Increased thoughts about suicide or self-harm, signs of an allergic reaction, vision changes, cardiovascular anomalies, low sodium level symptoms, severe nervous system reaction. | Signs of an allergic reaction, increased heart rate and/or irregular heartbeat, uncontrolled muscle movements, high fever with sweating and confusion, nausea with loss of appetite leading to significant weight loss, severe nervous system reaction. |
| Severe Drug Interactions | Interactions with Class 1A or Class III antiarrhythmics causing potentially serious heart rhythm abnormalities. | Interactions with Class 1A or Class III antiarrhythmics causing potentially serious heart rhythm abnormalities. |
| Typical Dose | 20-120 mg/day, starting dose often 40 mg/day for adults, 20 mg/day for adolescents. | 20 mg twice daily, can be increased to 60-80 mg, divided into two doses. Maximum dosage capped at 160 mg per day. |
What is Latuda?
Lurasidone (the generic name for Latuda) and Ziprasidone (Geodon) are both part of the atypical antipsychotics class of drugs. These medications marked a significant advancement in comparison to their predecessor, typical antipsychotics. Lurasidone was first approved by the FDA in 2010 and is used primarily for treating schizophrenic episodes in adults and teenagers who are at least 13 years old. It works by altering the effects of chemicals in the brain, including serotonin and dopamine. While it does have fewer side effects compared to some other antipsychotic drugs due to its selective influence on these neurotransmitters, it's important to note that there can still be severe side effects such as weight gain or metabolic changes.
Ziprasidone has similar uses but also includes treatment for acute manic or mixed episodes associated with bipolar disorder. Its approval predates Lurasidone's by nearly a decade, having been given FDA clearance back in 2001.
What conditions is Latuda approved to treat?
Latuda has been approved for the management of different types of psychiatric disorders, including:
- Schizophrenia in adults and adolescents (13 to 17 years old)
- Bipolar depression both as a solo treatment and as an adjunctive therapy with lithium or valproate in adults
- Bipolar depression in pediatric patients aged 10 to 17 years.
How does Latuda help with these illnesses?
Latuda works to manage symptoms of bipolar disorder and schizophrenia by affecting the levels of dopamine and serotonin in the brain. It achieves this by blocking certain receptors on the nerves in the brain for these neurotransmitters, so that their levels can be maintained higher for longer periods of time. Dopamine and serotonin are chemicals that act as messengers in the brain, playing important roles in mood regulation, cognition, memory, sleep patterns and other functions. In conditions such as bipolar disorder or schizophrenia, individuals often have imbalances of these neurotransmitters. Therefore, by adjusting dopamine and serotonin levels through receptor blockade, Latuda can help manage these psychiatric conditions and stabilize patients' moods.
What is Geodon?
Geodon, a brand name for ziprasidone, is an atypical antipsychotic that works by helping to restore the balance of certain natural substances in the brain. It's classified as a dopamine serotonin receptor antagonist (DSRA) and was first approved by the FDA in 2001. Geodon doesn't inhibit the reuptake of serotonin like SSRI antidepressants do. This difference means its side-effect profile is also unique compared to SSRIs; particularly, it does not often cause weight gain or sexual dysfunction, which are common side effects with SSRIs such as Prozac. The impacts on dopamine and serotonin can be beneficial for treating symptoms of schizophrenia and bipolar disorder, especially in patients who may not respond well to typical antipsychotics or mood stabilizers.
What conditions is Geodon approved to treat?
Geodon, also known as ziprasidone, is an FDA-approved medication for the treatment of:
- Schizophrenia
- Acute manic or mixed episodes associated with bipolar disorder
It can be used in adults and children aged 10 years and above. It should be noted that Geodon has been shown to help manage symptoms but it's not a cure for these conditions. Always talk to your healthcare provider about the best treatment options for you.
How does Geodon help with these illnesses?
Dopamine is a neurotransmitter that plays an important role in motivation, reward, and how the brain perceives reality. Imbalances of this chemical messenger have been implicated in mental health disorders like schizophrenia and bipolar disorder. Geodon works by balancing dopamine levels available within the brain, thereby managing some symptoms of these conditions. Its action on serotonin may also play roles in its effectiveness as an antipsychotic medication. Since it has significant effects on both dopamine and serotonin systems, it is often prescribed when patients do not respond well to other atypical antipsychotics (such as Latuda), or may be combined with them for more effective treatment outcomes.
How effective are both Latuda and Geodon?
Lurasidone (Latuda) and ziprasidone (Geodon) are both second-generation antipsychotics with established histories of success in treating patients with schizophrenia. They were approved by the FDA within a decade of each other, both acting on similar neurotransmitters, dopamine and serotonin receptors.
In terms of effectiveness in alleviating symptoms of schizophrenia, several studies have been performed comparing these two drugs. One double-blind clinical trial conducted in 2013 concluded that lurasidone was as effective as ziprasidone in managing symptoms associated with schizophrenia and had comparable safety profiles. In this study, no significant difference was found between patients receiving either drug regarding scores on standard measures used to assess symptom severity or improvement.
A 2015 review reported lurasidone to be highly efficacious from the first week of treatment for acute exacerbations of schizophrenia. It also has a favorable side effect profile compared to many other antipsychotics due to less frequent extrapyramidal symptoms or weight gain issues making it more acceptable among elderly populations.
However, a meta-analysis published in 2018 indicated that while lurasidone appears to be more effective than placebo at reducing psychotic episodes related to schizophrenia, its efficacy seems equivalent when compared directly against other common antipsychotic medications like ziprasidone. Despite this equivalence overall efficacy-wise, ziprasidone is often considered after or alongside first-line treatments due its potential for QT interval prolongation which can lead to serious heart rhythm disturbances.
Nonetheless because of their unique pharmacology focusing mainly on serotonin-dopamine activity modulation unlike traditional neuroleptics which predominantly block dopamine receptors alone; either could be an optimal choice based upon patient's individual needs such as preference towards lesser metabolic side effects - characteristic feature seen comparatively less commonly with these agents versus others falling under same class.
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At what dose is Latuda typically prescribed?
Oral dosages of Latuda range from 20-120 mg/day, but studies have suggested that a starting dose of around 40 mg/day is often effective for treating bipolar depression in adults. Adolescents aged 13 to 17 may initially be started on 20 mg/day. In either population, the dosage can be increased after a week if there are no significant improvements in symptoms. The maximum daily dosage that should not be exceeded under any circumstances is 160 mg/day when used for schizophrenia and 120mg/day when used for bipolar disorder.
At what dose is Geodon typically prescribed?
Geodon treatment is typically initiated at a dosage of 20 mg twice daily. The dose can then be increased to 60-80 mg, divided into two doses and spaced approximately 12 hours apart. Maximum dosage for Geodon is usually capped at 160 mg per day, split into two doses of 80 mg each. If there's no response to the initial treatment after several weeks, your healthcare provider may consider adjusting the dose within the recommended range or switching medications entirely. As with any medication regimen, it's crucial that patients adhere strictly to their doctor's instructions when taking Geodon.
What are the most common side effects for Latuda?
Common side effects of Latuda (lurasidone) and Geodon (ziprasidone) may include:
- Drowsiness, fatigue or general weakness
- Restlessness or feeling jittery
- Insomnia or sleep disturbances
- Nausea, vomiting, stomach discomfort
- Weight gain
- Dry mouth
- Indigestion or constipation
- Uncontrolled body movements such as tremors, shaking, stiffness
- Anxiety and nervousness
-Decreased sexual desire or ability
-Rash on the skin
-Increased salivation
-Sweating excessively
-Cold-like symptoms such as sinusitis or pharyngitis.
Please consult a healthcare provider if you experience any of these side effects to determine the best course of action.
Are there any potential serious side effects for Latuda?
While taking Latuda, it's important to be aware of potential serious side effects which can include:
- Increased thoughts about suicide or self-harm, especially in younger individuals
- Signs of an allergic reaction such as difficulty breathing or swallowing, hives, swelling in your face or throat
- Vision changes such as blurred vision or tunnel vision; eye pain or swelling; seeing halos around lights
- Cardiovascular anomalies: rapid heartbeats, palpitations in your chest area, shortness of breath and sudden dizziness (as if you might faint)
- Low sodium level symptoms - headache, confusion, slurred speech accompanied by severe weakness and vomiting. Loss of coordination could also occur leading to a feeling unsteadiness
- Symptoms indicating a severe nervous system reaction like very stiff (rigid) muscles coupled with high fever and sweating. Confusion may arise along with fast-paced uneven heartbeats and tremors. You might also feel like you are going to faint.
For Geodon:
Some people on Geodon have experienced similar but not identical side effects:
-An increased risk for suicidal thinking has been noted primarily among children and young adults under the age 24. -Symptoms indicative of an allergic reaction that may require immediate medical attention include hives; trouble breathing; swelling involving the face/lips/tongue/throat. -Disturbances in vision such as blurry sight or seeing things that don't exist (hallucinations). -Accelerated heartbeat rate which could make one feel light-headed almost close to passing out. Other cardiovascular issues could lead to chest pain/pressure spreading towards the jaw/left arm followed by nausea/sweating. -Low levels of sodium marked by symptoms like headache/confusion/more concentration difficulties/memory problems/weakness/unsteady feeling causing falling spells/severe constipation/trouble speaking/swelling in hands/feet/ankles/lower legs/intense hunger/thirst/frequent urination/dry skin/blurred vision/pounding heartbeat/shallow breathing/muscle stiffness/shaking/cold/clammy skin/blue lips/nails/coma/death.
In case you experience any adverse reactions from either medication it is imperative that you contact your healthcare provider immediately.
What are the most common side effects for Geodon?
While taking Geodon, you might experience:
- Dry mouth or a sore throat
- Nausea, stomach upset, constipation
- Blurred vision
- Sleep problems such as insomnia
- Tremors, muscle spasms or stiffness
- Feeling restless or nervous
- Changes in heart rhythm and increased heartbeat
- Weight gain instead of loss is common with antipsychotic medicines like Geodon. -Dizziness upon standing (orthostatic hypotension) -Possible rash appearance. -Increased urination could occur as well as nasal congestion.
Please note that this list is not exhaustive and some patients may not experience these side effects. It's important to consult your healthcare provider if you notice any unusual changes while on the medication.
Are there any potential serious side effects for Geodon?
Geodon, like any medication, carries the risk of possible side effects. In some instances, these can be severe and call for immediate medical attention:
- Signs of an allergic reaction: hives; difficulty breathing; swelling in your face, lips, tongue or throat
- A rash that is blistering or peeling
- Increased heart rate and/or irregular heartbeat
- Uncontrolled muscle movements such as tremors or jerking
- High fever with sweating and confusion
- Nausea with loss of appetite leading to significant weight loss
- Severe nervous system reaction (very rigid muscles, high fever, sweating)
If you exhibit any symptoms mentioned above after starting Geodon treatment it's important to seek immediate medical help.
Contraindications for Latuda and Geodon?
Both Latuda and Geodon, two antipsychotic medicines, may exacerbate symptoms of depression in some individuals. If you notice your depression worsening or an increase in suicidal thoughts or behaviors after starting either medication, seek immediate medical attention.
Latuda and Geodon should not be taken by anyone who is currently taking—or has recently been on—medications known as Class 1A or Class III antiarrhythmics. These medications can interact with both Latuda and Geodon causing potentially serious heart rhythm abnormalities. Always inform your doctor about all the medications you are using; drugs like antiarrhythmics need a washout period to prevent dangerous interactions with Latuda and Geodon. It's also critical to note that both these antipsychotic medications should ideally be taken with food for best absorption into the body system.
How much do Latuda and Geodon cost?
For the brand name versions of these drugs:
- The price of 30 tablets of Latuda (40 mg) averages around $1400, which works out to $46–93/day, depending on your dose.
- The price of 60 capsules of Geodon (20 mg) is about $600, working out to approximately $10/day.
Thus, if you are in the higher dosage range for Latuda (i.e., 80 mg/day or higher), then brand-name Geodon is less expensive on a per-day treatment basis. Please note that cost should not be a primary consideration in determining which of these drugs is right for you.
For the generic versions of Latuda (lurasidone) and Geodon (ziprasidone), costs differ significantly:
- Lurasidone is available in packs from 30 tablets and above, with approximate costs ranging from $1 to over $3 per day for dosages starting at 20mg up to typical dosages between 40mg -160mg.
- Ziprasidone comes in quantities ranging from packs with as few as four pills up to hundreds. Its cost starts from just under a dollar per day and could rise up towards two dollars daily depending on whether you're taking lower doses like 20mg twice a day or are closer towards an average maximum daily dosage such as around the region of ~160mg.
Popularity of Latuda and Geodon
Lurasidone, available under the brand name Latuda, was prescribed to approximately 1 million people in the United States in 2020. Lurasidone is often used as a treatment for schizophrenia and bipolar depression. Accounting for just over 4% of antipsychotic prescriptions within the US, lurasidone has seen a steady increase in usage since its FDA approval in 2010.
Ziprasidone, also known by its brand name Geodon among others, was prescribed to roughly half a million people within America during the same year. Ziprasidone accounts for about 2% of antipsychotic prescriptions across the nation and is primarily utilized as an intervention against schizophrenia and manic episodes associated with bipolar disorder. Unlike lurasidone's consistent rise in prescription numbers, ziprasidone's frequency has plateaued over recent years following initial growth after receiving FDA approval back in early 2001.
Conclusion
Both Latuda (lurasidone) and Geodon (ziprasidone) have been widely used in the treatment of schizophrenia, and also as adjunctive therapy for bipolar depression. Both drugs are atypical antipsychotics that act on a variety of neurotransmitter systems. They have demonstrated efficacy in clinical studies, surpassing placebo treatments.
Latuda mainly interacts with serotonin and dopamine receptors while Geodon works primarily by blocking activity at dopamine and serotonin receptors. These different mechanisms of action mean they may be prescribed under distinct circumstances based on individual patient needs.
While both medications come in generic form which alleviates some financial burden for patients paying out-of-pocket, Latuda is generally more expensive than Geodon.
An adjustment period may be required upon initiating either medication; noticeable effects might not occur immediately after starting treatment.
The side effect profiles for these two medications share similarities but differ notably in certain aspects. While both can cause drowsiness or restlessness, Latuda is less likely to affect heart rhythm compared to Geodon but has a higher risk of causing weight gain. For any new or worsening symptoms such as mood swings, suicidal thoughts or self-harm tendencies during treatment with either drug, immediate medical attention should be sought.
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Refrences
- Swainston Harrison, T., & Scott, L. J. (2006). Ziprasidone. CNS Drugs. Springer Science and Business Media LLC.http://doi.org/10.2165/00023210-200620120-00006
- Potkin, S. G., Ogasa, M., Cucchiaro, J., & Loebel, A. (2011, November). Double-blind comparison of the safety and efficacy of lurasidone and ziprasidone in clinically stable outpatients with schizophrenia or schizoaffective disorder. Schizophrenia Research. Elsevier BV.http://doi.org/10.1016/j.schres.2011.04.008
- Sanford, M., & Dhillon, S. (2015, February 20). Lurasidone: A Review of Its Use in Adult Patients with Bipolar I Depression. CNS Drugs. Springer Science and Business Media LLC.http://doi.org/10.1007/s40263-015-0234-2
- Biswas, A. K., M.D., F.A., Zabrocki, L. A., M.D.,, Mayes, K. L., Pharm.D.,, & Morris-Kukoski, C. L., Pharm.D.,. (2003, January). Cardiotoxicity Associated With Intentional Ziprasidone And Bupropion Overdose. Journal of Toxicology: Clinical Toxicology. Informa UK Limited.http://doi.org/10.1081/clt-120018276
- Pompili, M., Verzura, C., Trovini, G., Buscajoni, A., Falcone, G., Naim, S., … Girardi, P. (2017, September 26). Lurasidone: efficacy and safety in the treatment of psychotic and mood disorders. Expert Opinion on Drug Safety. Informa UK Limited.http://doi.org/10.1080/14740338.2017.1379989