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What is Celecoxib
CelecoxibThe Generic name of this drug
Treatment SummaryCelecoxib is a medication used to reduce inflammation and treat pain caused by arthritis. It is also used to reduce the risk of precancerous polyps in people with a genetic condition called familial adenomatous polyposis. Celecoxib is an NSAID, meaning it is a nonsteroidal anti-inflammatory drug, and is known to have a lower risk of causing gastrointestinal bleeding than other NSAIDs. It was approved by the FDA in 1998 and is sold under the brand name Celebrex. Celecoxib has also been studied as a potential cancer-fighting drug in clinical trials.
Celebrexis the brand name
Celecoxib Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Celebrex
Celecoxib
1998
379
Approved as Treatment by the FDA
Celecoxib, otherwise called Celebrex, is approved by the FDA for 6 uses which include Rheumatoid Arthritis, Juvenile and Acute Pain .Rheumatoid Arthritis, Juvenile
Helps manage Rheumatoid Arthritis, Juvenile
Acute Pain
Helps manage Pain, Acute
Ankylosing Spondylitis
Helps manage Ankylosing Spondylitis (AS)
Rheumatoid Arthritis
Helps manage Rheumatoid Arthritis
Primary Dysmenorrhoea
Helps manage Primary Dysmenorrhoea
Osteoarthritis
Helps manage Osteoarthritis (OA)
Effectiveness
How Celecoxib Affects PatientsCelecoxib is a painkiller and anti-inflammatory that reduces pain and swelling by stopping the COX-2 enzyme from working. Although it is less likely to cause bleeding than other NSAIDs, it is still possible and should be used with caution in those at high risk for gastrointestinal bleeding. In the early 2000s, concerns were raised about the safety of COX-2 inhibitors including Vioxx. After studying data from large clinical trials, the FDA concluded that there was a risk of cardiovascular events with both COX-2 inhibitors and nonselective NSAIDs, but that the benefits of celecoxib outweighed
How Celecoxib works in the bodyCelecoxib is a type of drug called a non-steroidal anti-inflammatory (NSAID). It works by blocking an enzyme called cyclooxygenase-2 (COX-2), which reduces the amount of certain substances that cause pain and inflammation. Unlike other NSAIDs, celecoxib has less of an effect on the stomach and causes less ulceration. Celecoxib also has anticancer effects by binding to certain proteins and inhibiting certain signaling pathways. The use of celecoxib may also increase the risk of thrombotic events because it stops the production of substances that inhibit platelet aggregation.
When to interrupt dosage
The advisable dosage of Celecoxib is subject to the diagnosed affliction, including Ankylosing Spondylitis, Primary Dysmenorrhoea and Rheumatoid Arthritis. The quantity of dosage is contingent upon the way of administration (e.g. Tablet - Oral or Oral) listed in the table beneath.Condition
Dosage
Administration
Rheumatoid Arthritis
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Rheumatoid Arthritis, Juvenile
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Osteoarthritis
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Ankylosing Spondylitis
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Acute Pain
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Primary Dysmenorrhoea
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Therapeutic procedure
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Pain
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Warnings
Celecoxib ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Celecoxib may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Celecoxib may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Celecoxib may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Celecoxib may interact with Pulse Frequency
Common Celecoxib Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Celecoxib.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Celecoxib.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Celecoxib is combined with Cyclopentamine.
Fluorouracil
Major
The metabolism of Fluorouracil can be decreased when combined with Celecoxib.
Fosphenytoin
Major
The metabolism of Fosphenytoin can be decreased when combined with Celecoxib.
Celecoxib Toxicity & Overdose RiskCelecoxib should not be given to those with kidney or liver problems as it could be toxic and cause adverse side effects. Overdosing on celecoxib may cause breathing difficulties, drowsiness, stomach bleeding, high blood pressure, kidney failure, nausea, sluggishness, stomach pain, and vomiting. If the patient has taken celecoxib within the last 4 hours, vomiting or activated charcoal should be induced. Diuresis, alkalinization of urine, hemodialysis or hemoperfusion may not help if the drug is highly protein bound. Patients should be monitored for signs and symptoms of gastrointestinal bleeding.
Celecoxib Novel Uses: Which Conditions Have a Clinical Trial Featuring Celecoxib?
102 active clinical trials are presently examining the utility of Celecoxib in providing relief from Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis and Primary Dysmenorrhoea.Condition
Clinical Trials
Trial Phases
Rheumatoid Arthritis
58 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Acute Pain
34 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Osteoarthritis
0 Actively Recruiting
Ankylosing Spondylitis
3 Actively Recruiting
Phase 3, Not Applicable
Pain
0 Actively Recruiting
Rheumatoid Arthritis, Juvenile
2 Actively Recruiting
Not Applicable
Primary Dysmenorrhoea
1 Actively Recruiting
Not Applicable
Therapeutic procedure
0 Actively Recruiting
Celecoxib Reviews: What are patients saying about Celecoxib?
5Patient Review
4/17/2021 I've been dealing with arthritis for a few years now and haven't had much relief from Mobic. I just had a partial knee replacement, and my doctor put me on Celebrex. It's been fantastic! Not only does it relieve the pain in my other joints (hips, knees, back), but it also allows me to be more active since I'm not constantly in pain. I just wish I could take this long-term.
5Patient Review
6/22/2021 Three weeks ago, I had a knee replacement. The hospital put me on this medication for pain relief and, finally, I have no pain. There is still discomfort from the healing process but that's to be expected. Now I can try to get my life back and start exercising again.
5Patient Review
10/9/2022 I've taken this medication for years with great results. Recently, however, the pain has come back almost as severe as it was when I first started taking the medication. Has anyone else experienced this?
5Patient Review
3/2/2022 This medication has really helped me. I have bursitis in my hips and was struggling with stiffness and quality of life. Taking just one 100mg pill a day has alleviated all of those issues.
5Patient Review
11/23/20175Patient Review
12/5/20175Patient Review
11/7/2019 This medication is very effective at managing my pain after several knee surgeries.
5Patient Review
8/17/2020 I have severe pain and inflammation from fibromyalgia, DDD and osteoarthritis of the spine. I've tried everything over-the-counter, but this is the only thing that has really given me relief.
4.3Patient Review
1/11/2019 I experienced nausea and severe heartburn when using this medication, even though I was also taking Pantoprazole. It did have a modest effect on my pain, but now I have other problems as a result.
3Patient Review
5/16/2020 I was in a lot of pain after my accident, but Celebrex really helped. I would recommend taking it with food to avoid stomach upset, and using ice or heat packs as well.
3Patient Review
5/24/2021 I used celecoxib for pain and inflammation from a back surgery 5 months ago. It did help, but after about ten days I started to experience some serious stomach pain. I'm sensitive to NSAIDs, and while that wasn't an issue at first, it quickly became one.
2.7Patient Review
6/27/2021 While this treatment did not fully take away my pain, it was a marked improvement from other options I've tried.
2.3Patient Review
12/29/2020 I still have a lot of pills left over from this treatment! It didn't work any better for me than the NSAIDs I've tried in the past. The only thing that's helped me is Prednisone, but I know that's not a long-term solution. Is there anything else out there that can replicate the good effects without the bad side effects?
2.3Patient Review
2/22/2018 This has relieved the pain and swelling in my knees to a point where I can walk without discomfort. The generic version works just as well, so there's no need to overspend.
1Patient Review
2/18/2018 Not only did this completely remove the pain I was experiencing, but it also took care of the inflammation in the operated-on area. This made it so that walking didn't make the swelling worse like it did before. Much better than panadol oeteo and endone!
1Patient Review
2/18/2022 I had an extreme allergic reaction to this medication, going into anaphylaxis after only taking one pill. My lips, tongue, and throat swelled up within a few hours, and I had to go to the emergency room.
1Patient Review
7/29/2018 I'm 200mg into this treatment and I haven't felt any relief from my pain or swelling.
Patient Q&A Section about celecoxib
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the major side effect of celecoxib?
"If you experience any of the following symptoms, you may be suffering from indigestion: stomach pain, heartburn, gas, diarrhea, constipation, nausea, vomiting; swelling in your hands or feet; dizziness; or cold symptoms such as stuffy nose, sneezing, sore throat."
Answered by AI
What kind of pain killer is celecoxib?
"Celecoxib reduces inflammation by blocking the production of natural substances that cause it. This can decrease swelling, pain, or fever."
Answered by AI
Is celecoxib stronger than ibuprofen?
"There is no definitive answer as to which medication is better for pain relief as it depends on the specific type of pain."
Answered by AI