Celecoxib

Rheumatoid Arthritis, Arthritis, Juvenile, Osteoarthritis + 5 more

Treatment

10 FDA approvals

20 Active Studies for Celecoxib

Treatment for

Rheumatoid Arthritis

What is Celecoxib

CelecoxibThe Generic name of this drug

Treatment SummaryCelecoxib is a medication used to reduce inflammation and treat pain caused by arthritis. It is also used to reduce the risk of precancerous polyps in people with a genetic condition called familial adenomatous polyposis. Celecoxib is an NSAID, meaning it is a nonsteroidal anti-inflammatory drug, and is known to have a lower risk of causing gastrointestinal bleeding than other NSAIDs. It was approved by the FDA in 1998 and is sold under the brand name Celebrex. Celecoxib has also been studied as a potential cancer-fighting drug in clinical trials.

Celebrexis the brand name

image of different drug pills on a surface

Celecoxib Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Celebrex

Celecoxib

1998

379

Approved as Treatment by the FDA

Celecoxib, otherwise called Celebrex, is approved by the FDA for 10 uses which include Arthritis, Juvenile and Acute Pain .

Arthritis, Juvenile

Helps manage Rheumatoid Arthritis, Juvenile

Acute Pain

Helps manage Pain, Acute

Rheumatoid Arthritis, Juvenile

Helps manage Rheumatoid Arthritis, Juvenile

Pain, Acute

Helps manage Pain, Acute

Ankylosing Spondylitis (AS)

Helps manage Ankylosing Spondylitis (AS)

Osteoarthritis (OA)

Helps manage Osteoarthritis (OA)

Ankylosing Spondylitis

Helps manage Ankylosing Spondylitis (AS)

Rheumatoid Arthritis

Helps manage Rheumatoid Arthritis

Primary Dysmenorrhoea

Helps manage Primary Dysmenorrhoea

Osteoarthritis

Helps manage Osteoarthritis (OA)

Effectiveness

How Celecoxib Affects PatientsCelecoxib is a painkiller and anti-inflammatory that reduces pain and swelling by stopping the COX-2 enzyme from working. Although it is less likely to cause bleeding than other NSAIDs, it is still possible and should be used with caution in those at high risk for gastrointestinal bleeding. In the early 2000s, concerns were raised about the safety of COX-2 inhibitors including Vioxx. After studying data from large clinical trials, the FDA concluded that there was a risk of cardiovascular events with both COX-2 inhibitors and nonselective NSAIDs, but that the benefits of celecoxib outweighed

How Celecoxib works in the bodyCelecoxib is a type of drug called a non-steroidal anti-inflammatory (NSAID). It works by blocking an enzyme called cyclooxygenase-2 (COX-2), which reduces the amount of certain substances that cause pain and inflammation. Unlike other NSAIDs, celecoxib has less of an effect on the stomach and causes less ulceration. Celecoxib also has anticancer effects by binding to certain proteins and inhibiting certain signaling pathways. The use of celecoxib may also increase the risk of thrombotic events because it stops the production of substances that inhibit platelet aggregation.

When to interrupt dosage

The advisable dosage of Celecoxib is subject to the diagnosed affliction, including Ankylosing Spondylitis, Primary Dysmenorrhoea and Rheumatoid Arthritis. The quantity of dosage is contingent upon the way of administration (e.g. Tablet - Oral or Oral) listed in the table beneath.

Condition

Dosage

Administration

Rheumatoid Arthritis

50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL