Duoneb

Allergic Rhinitis, Bronchial Spasm, Asthma + 8 more
Treatment
1 FDA approval
20 Active Studies for Duoneb

What is Duoneb

IpratropiumThe Generic name of this drug
Treatment SummaryIpratropium is a medication used to prevent airway muscles from tightening. It is usually inhaled and has very little absorption into the bloodstream. Ipratropium was developed by Boehringer Ingelheim and was first approved by the FDA in 1986. A combination of Ipratropium and albuterol was approved in 1996.
Atroventis the brand name
image of different drug pills on a surface
Duoneb Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Atrovent
Ipratropium
1986
115

Approved as Treatment by the FDA

Ipratropium, otherwise known as Atrovent, is approved by the FDA for 1 uses such as Chronic Obstructive Pulmonary Disease .
Chronic Obstructive Pulmonary Disease
Used to treat Chronic Obstructive Pulmonary Disease (COPD) in combination with Salbutamol

Effectiveness

How Duoneb Affects PatientsIpratropium is a short-acting medication that helps to relax the breathing tubes in the lungs, relieving symptoms like wheezing, chest tightness, and coughing. It usually takes 1-2 hours for the drug to take effect, and its effects last 4-6 hours. Studies have found that ipratropium can help to improve breathing in those with asthma attacks, but it has not been proven to be beneficial for long-term use or for preventing asthma attacks.
How Duoneb works in the bodyIpratropium works by blocking the effects of the parasympathetic nervous system on the airways. This system normally causes airways to become narrower due to muscle contractions, but when Ipratropium blocks it, airways can stay relaxed and wide. This also decreases the production of bronchial secretions. On a cellular level, Ipratropium blocks acetylcholine from binding to muscle cells, which prevents them from contracting and allowing airways to remain relaxed.

When to interrupt dosage

The dosage of Duoneb is contingent upon the diagnosed condition, such as Chronic Obstructive Pulmonary Disease (COPD), Asthma and Non-Allergic Rhinitis. The measure of dosage is contingent upon the mode of delivery outlined in the table hereunder.
Condition
Dosage
Administration
Chronic Obstructive Pulmonary Disease
, 0.5 mg/mL, 0.021 mg, 0.042 mg, 0.017 mg, 0.5 mg, 0.02 mg, 0.018 mg, 0.25 mg/mL, 0.125 mg/mL, 0.3 mg/mL, 0.042 mg/pump actuation, 0.02 mg/pump actuation, 0.021 mg/pump actuation
, Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Nasal, Spray, metered - Nasal, Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Spray, Spray - Nasal, Liquid, Liquid - Respiratory (inhalation), Nasal; Respiratory (inhalation), Solution - Nasal, Aerosol, Aerosol - Nasal; Respiratory (inhalation), Solution - Nasal; Respiratory (inhalation), Spray, metered - Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Spray - Respiratory (inhalation)
Non-Allergic Rhinitis
, 0.5 mg/mL, 0.021 mg, 0.042 mg, 0.017 mg, 0.5 mg, 0.02 mg, 0.018 mg, 0.25 mg/mL, 0.125 mg/mL, 0.3 mg/mL, 0.042 mg/pump actuation, 0.02 mg/pump actuation, 0.021 mg/pump actuation
, Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Nasal, Spray, metered - Nasal, Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Spray, Spray - Nasal, Liquid, Liquid - Respiratory (inhalation), Nasal; Respiratory (inhalation), Solution - Nasal, Aerosol, Aerosol - Nasal; Respiratory (inhalation), Solution - Nasal; Respiratory (inhalation), Spray, metered - Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Spray - Respiratory (inhalation)
Emphysema
, 0.5 mg/mL, 0.021 mg, 0.042 mg, 0.017 mg, 0.5 mg, 0.02 mg, 0.018 mg, 0.25 mg/mL, 0.125 mg/mL, 0.3 mg/mL, 0.042 mg/pump actuation, 0.02 mg/pump actuation, 0.021 mg/pump actuation
, Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Nasal, Spray, metered - Nasal, Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Spray, Spray - Nasal, Liquid, Liquid - Respiratory (inhalation), Nasal; Respiratory (inhalation), Solution - Nasal, Aerosol, Aerosol - Nasal; Respiratory (inhalation), Solution - Nasal; Respiratory (inhalation), Spray, metered - Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Spray - Respiratory (inhalation)
Bronchitis, Chronic
, 0.5 mg/mL, 0.021 mg, 0.042 mg, 0.017 mg, 0.5 mg, 0.02 mg, 0.018 mg, 0.25 mg/mL, 0.125 mg/mL, 0.3 mg/mL, 0.042 mg/pump actuation, 0.02 mg/pump actuation, 0.021 mg/pump actuation
, Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Nasal, Spray, metered - Nasal, Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Spray, Spray - Nasal, Liquid, Liquid - Respiratory (inhalation), Nasal; Respiratory (inhalation), Solution - Nasal, Aerosol, Aerosol - Nasal; Respiratory (inhalation), Solution - Nasal; Respiratory (inhalation), Spray, metered - Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Spray - Respiratory (inhalation)
Rhinitis, Allergic
, 0.5 mg/mL, 0.021 mg, 0.042 mg, 0.017 mg, 0.5 mg, 0.02 mg, 0.018 mg, 0.25 mg/mL, 0.125 mg/mL, 0.3 mg/mL, 0.042 mg/pump actuation, 0.02 mg/pump actuation, 0.021 mg/pump actuation
, Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Nasal, Spray, metered - Nasal, Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Spray, Spray - Nasal, Liquid, Liquid - Respiratory (inhalation), Nasal; Respiratory (inhalation), Solution - Nasal, Aerosol, Aerosol - Nasal; Respiratory (inhalation), Solution - Nasal; Respiratory (inhalation), Spray, metered - Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Spray - Respiratory (inhalation)
Chronic Obstructive Airway Disease
, 0.5 mg/mL, 0.021 mg, 0.042 mg, 0.017 mg, 0.5 mg, 0.02 mg, 0.018 mg, 0.25 mg/mL, 0.125 mg/mL, 0.3 mg/mL, 0.042 mg/pump actuation, 0.02 mg/pump actuation, 0.021 mg/pump actuation
, Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Nasal, Spray, metered - Nasal, Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Spray, Spray - Nasal, Liquid, Liquid - Respiratory (inhalation), Nasal; Respiratory (inhalation), Solution - Nasal, Aerosol, Aerosol - Nasal; Respiratory (inhalation), Solution - Nasal; Respiratory (inhalation), Spray, metered - Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Spray - Respiratory (inhalation)
Allergic Rhinitis
, 0.5 mg/mL, 0.021 mg, 0.042 mg, 0.017 mg, 0.5 mg, 0.02 mg, 0.018 mg, 0.25 mg/mL, 0.125 mg/mL, 0.3 mg/mL, 0.042 mg/pump actuation, 0.02 mg/pump actuation, 0.021 mg/pump actuation
, Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Nasal, Spray, metered - Nasal, Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Spray, Spray - Nasal, Liquid, Liquid - Respiratory (inhalation), Nasal; Respiratory (inhalation), Solution - Nasal, Aerosol, Aerosol - Nasal; Respiratory (inhalation), Solution - Nasal; Respiratory (inhalation), Spray, metered - Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Spray - Respiratory (inhalation)
Bronchial Spasm
, 0.5 mg/mL, 0.021 mg, 0.042 mg, 0.017 mg, 0.5 mg, 0.02 mg, 0.018 mg, 0.25 mg/mL, 0.125 mg/mL, 0.3 mg/mL, 0.042 mg/pump actuation, 0.02 mg/pump actuation, 0.021 mg/pump actuation
, Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Nasal, Spray, metered - Nasal, Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Spray, Spray - Nasal, Liquid, Liquid - Respiratory (inhalation), Nasal; Respiratory (inhalation), Solution - Nasal, Aerosol, Aerosol - Nasal; Respiratory (inhalation), Solution - Nasal; Respiratory (inhalation), Spray, metered - Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Spray - Respiratory (inhalation)
Asthma
, 0.5 mg/mL, 0.021 mg, 0.042 mg, 0.017 mg, 0.5 mg, 0.02 mg, 0.018 mg, 0.25 mg/mL, 0.125 mg/mL, 0.3 mg/mL, 0.042 mg/pump actuation, 0.02 mg/pump actuation, 0.021 mg/pump actuation
, Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Nasal, Spray, metered - Nasal, Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Spray, Spray - Nasal, Liquid, Liquid - Respiratory (inhalation), Nasal; Respiratory (inhalation), Solution - Nasal, Aerosol, Aerosol - Nasal; Respiratory (inhalation), Solution - Nasal; Respiratory (inhalation), Spray, metered - Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Spray - Respiratory (inhalation)
Nasal Congestion Associated With the Common Cold
, 0.5 mg/mL, 0.021 mg, 0.042 mg, 0.017 mg, 0.5 mg, 0.02 mg, 0.018 mg, 0.25 mg/mL, 0.125 mg/mL, 0.3 mg/mL, 0.042 mg/pump actuation, 0.02 mg/pump actuation, 0.021 mg/pump actuation
, Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Nasal, Spray, metered - Nasal, Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Spray, Spray - Nasal, Liquid, Liquid - Respiratory (inhalation), Nasal; Respiratory (inhalation), Solution - Nasal, Aerosol, Aerosol - Nasal; Respiratory (inhalation), Solution - Nasal; Respiratory (inhalation), Spray, metered - Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Spray - Respiratory (inhalation)
Asthma
, 0.5 mg/mL, 0.021 mg, 0.042 mg, 0.017 mg, 0.5 mg, 0.02 mg, 0.018 mg, 0.25 mg/mL, 0.125 mg/mL, 0.3 mg/mL, 0.042 mg/pump actuation, 0.02 mg/pump actuation, 0.021 mg/pump actuation
, Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Nasal, Spray, metered - Nasal, Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Spray, Spray - Nasal, Liquid, Liquid - Respiratory (inhalation), Nasal; Respiratory (inhalation), Solution - Nasal, Aerosol, Aerosol - Nasal; Respiratory (inhalation), Solution - Nasal; Respiratory (inhalation), Spray, metered - Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Spray - Respiratory (inhalation)

Warnings

Duoneb has a single contraindication, and thus should not be employed when dealing with the ailments listed in the table below.Duoneb Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Duoneb.
Common Duoneb Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Ipratropium is combined with Aclidinium.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Ipratropium is combined with Cimetropium.
Eluxadoline
Major
The risk or severity of constipation can be increased when Ipratropium is combined with Eluxadoline.
Glycopyrronium
Major
The risk or severity of adverse effects can be increased when Ipratropium is combined with Glycopyrronium.
Macimorelin
Major
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Ipratropium.
Duoneb Toxicity & Overdose RiskThe lowest toxic dose of ipratropium in mice is 1500mg/kg, and it is unlikely to be overdosed due to its poor absorption. There are no known effects of ipratropium on cancer, birth defects, or mutations, however high doses may reduce the rate of conception.
image of a doctor in a lab doing drug, clinical research

Duoneb Novel Uses: Which Conditions Have a Clinical Trial Featuring Duoneb?

282 active studies are currently being conducted to examine the possible benefits of Duoneb in ameliorating Asthma, Bronchospasm and Perennial Allergic Rhinitis (PAR).
Condition
Clinical Trials
Trial Phases
Chronic Obstructive Airway Disease
0 Actively Recruiting
Asthma
103 Actively Recruiting
Phase 4, Not Applicable, Early Phase 1, Phase 2, Phase 3, Phase 1
Chronic Obstructive Pulmonary Disease
90 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4
Bronchial Spasm
0 Actively Recruiting
Bronchitis, Chronic
1 Actively Recruiting
Not Applicable
Asthma
0 Actively Recruiting
Allergic Rhinitis
0 Actively Recruiting
Rhinitis, Allergic
0 Actively Recruiting
Emphysema
7 Actively Recruiting
Phase 4, Not Applicable, Phase 2
Nasal Congestion Associated With the Common Cold
0 Actively Recruiting
Non-Allergic Rhinitis
0 Actively Recruiting

Duoneb Reviews: What are patients saying about Duoneb?

5Patient Review
9/9/2012
Duoneb for Bronchi Muscle Spasm resulting from COPD
I appreciate the convenience of this treatment, but unfortunately it gives me really bad muscle spasms that are incredibly painful. I'll be bringing it up with my doctor next week.
5Patient Review
8/2/2012
Duoneb for Bronchi Muscle Spasm resulting from COPD
I had at least four exacerbations before being prescribed DuoNeb. My breathing problems were due to pneumonia, so I can't really say how these other patients have recovered. You can't believe all that they write, because everyone responds differently yo various types of medications. If a drug works for you, use it. If not try something else.
5Patient Review
2/17/2014
Duoneb for Bronchi Muscle Spasm resulting from COPD
It relieved my breathing restrictions without making my heart beat too fast or making me nervous.
5Patient Review
3/29/2012
Duoneb for Bronchi Muscle Spasm resulting from COPD
I rapidly developed a fever, headache, and trembling after taking this medication. My heart rate also increased significantly.
4.3Patient Review
1/20/2022
Duoneb for Bronchi Muscle Spasm resulting from COPD
I've been on DuoNeb since 2018 and it's really helped me a lot. Not only does it help me to get sputum up, but it also improves wheezing significantly. Plus, I don't have to worry about raising my heart rate or getting palpitations like I do with my stand alone Albuterol solution. The only downside is the frequency of doses.
3.7Patient Review
4/18/2008
Duoneb for Bronchi Muscle Spasm resulting from COPD
I was given this medicine during a bad asthma flare to see if it would work better than albuterol alone. The first few doses worked great, although I lost my voice. The last two doses actually made me worse. The first of these I took during an attack, and got much worse, chest was very tight, and wheezing increased. The second dose I took when feeling fine to see what would happen, and within 1 minute, I was having an asthma attack.
3.7Patient Review
11/2/2007
Duoneb for Bronchi Muscle Spasm resulting from COPD
3Patient Review
7/5/2017
Duoneb for Bronchi Muscle Spasm resulting from COPD
While Albuterol did help with my A fib at first, after awhile it started to make my heart race uncontrollably. I had to stop taking it and ended up getting a pacemaker.
3Patient Review
3/15/2010
Duoneb for Osteoporosis
This treatment helps me to get up the phlegm that's been clogging my breathing.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about duoneb

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is DuoNeb solution used for?

"What is DuoNeb used for? DuoNeb is used to help treat airway narrowing (bronchospasm) that happens with chronic obstructive pulmonary disease (COPD). It is for adult patients who need to use more than one bronchodilator medicine. The active ingredients are albuterol sulfate and ipratropium bromide."

Answered by AI

What type of bronchodilator is DuoNeb?

"DuoNeb is a bronchodilator that is a combination of albuterol and ipratropium. This medication relaxes the muscles in the airway and increases air flow to the lungs to help with breathing."

Answered by AI

What is the difference between DuoNeb and albuterol?

"Duoneb (ipratropium / albuterol) is a combination of ipratropium, a short-acting muscarinic antagonist, and albuterol, a short-acting beta-agonist, that help you breathe."

Answered by AI

What is DuoNeb breathing treatment?

"DuoNeb is a combination of two bronchodilators, ipratropium bromide and albuterol sulfate, used to treat and prevent the symptoms of chronic obstructive pulmonary disease (COPD), including bronchitis and emphysema."

Answered by AI

Clinical Trials for Duoneb

Have you considered Duoneb clinical trials? We made a collection of clinical trials featuring Duoneb, we think they might fit your search criteria.
Have you considered Duoneb clinical trials? We made a collection of clinical trials featuring Duoneb, we think they might fit your search criteria.
Have you considered Duoneb clinical trials? We made a collection of clinical trials featuring Duoneb, we think they might fit your search criteria.
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Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
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