Oxsoralen

Vitiligo, Vitiligo, Psoriasis + 3 more
Treatment
18 Active Studies for Oxsoralen

What is Oxsoralen

MethoxsalenThe Generic name of this drug
Treatment SummaryPsoralen is a natural chemical found in some plants, such as Psoralea corylifolia. It becomes activated when exposed to ultraviolet A radiation and binds to DNA molecules.
Oxsoralenis the brand name
Oxsoralen Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Oxsoralen
Methoxsalen
1954
7

Effectiveness

How Oxsoralen Affects PatientsMethoxsalen stops the body from making DNA. The amount of DNA produced is related to how much Methoxsalen is used. If a large amount is used, the production of RNA and proteins in cells will also be reduced.
How Oxsoralen works in the bodyAfter it is activated, this drug binds tightly to the DNA in your cells, creating a link between two strands of DNA. This stops the DNA from carrying out its normal functions, preventing cell growth.

When to interrupt dosage

The advised measure of Oxsoralen is contingent upon the diagnosed disorder, including Palliative Care, Vitiligo and Psoriasis. The dosage amount also fluctuates as per the technique of delivery (e.g. Solution - Extracorporeal or Topical) outlined in the table beneath.
Condition
Dosage
Administration
Vitiligo
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical
Vitiligo
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical
Psoriasis
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical
Lymphoma, T-Cell, Cutaneous
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical
Palliative Treatment
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical
CTAGE1 protein, human
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical

Warnings

Oxsoralen has five contraindications, therefore it should not be taken alongside any of the conditions given in the following table.Oxsoralen Contraindications
Condition
Risk Level
Notes
Aphakia
Do Not Combine
melanoma
Do Not Combine
Squamous cell carcinoma
Do Not Combine
Photophobia
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Oxsoralen.
Common Oxsoralen Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Methoxsalen.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Methoxsalen.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Methoxsalen.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Methoxsalen.
Bendamustine
Major
The metabolism of Bendamustine can be decreased when combined with Methoxsalen.
image of a doctor in a lab doing drug, clinical research

Oxsoralen Novel Uses: Which Conditions Have a Clinical Trial Featuring Oxsoralen?

40 active clinical trials are currently investigating the potential of Oxsoralen to treat Lymphoma, Cutaneous T-Cell Lymphoma, CTAGE1 protein and Human Palliative Care.
Condition
Clinical Trials
Trial Phases
Vitiligo
0 Actively Recruiting
Psoriasis
0 Actively Recruiting
Lymphoma, T-Cell, Cutaneous
0 Actively Recruiting
Vitiligo
9 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Palliative Treatment
0 Actively Recruiting
CTAGE1 protein, human
9 Actively Recruiting
Phase 1, Not Applicable, Phase 2, Early Phase 1

Oxsoralen Reviews: What are patients saying about Oxsoralen?

5Patient Review
6/25/2009
Oxsoralen for Severe Psoriasis that is Resistant to Treatment
I find that consuming food an hour before taking the pill helps with any potential nausea. Additionally, I sometimes have trouble sleeping two days after taking the medication; however, this has been my only real complaint.
3.7Patient Review
2/17/2009
Oxsoralen for Severe Psoriasis that is Resistant to Treatment
The medicine has been tough to stomach, even after a couple months of treatment. I've also found myself feeling really exhausted recently, sleeping for up to twelve or fourteen hours straight on weekends.
3Patient Review
5/12/2008
Oxsoralen for Severe Psoriasis that is Resistant to Treatment
3Patient Review
3/15/2010
Oxsoralen for Osteoporosis
This treatment really helped me. I'm grateful for modern medicine.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about oxsoralen

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Ultra drug?

"This medication contains vitamins that are important for the body. They help keep you healthy and can be used to treat or prevent vitamin deficiency."

Answered by AI

What is oxsoralen used for?

"This medication is used in conjunction with exposure to controlled ultraviolet light (UVA) to help alleviate severe psoriasis. It may also be effective for other skin conditions such as vitiligo or cutaneous T-cell lymphoma-CTCL. Methoxsalen works by making the skin more sensitive to UVA light."

Answered by AI

How do you use Melanocyl solution?

"Take this MELANOCYL SOLUTION 25ML by mouth with milk or food, normally 2 to 4 hours before your UVA light treatment. Stay out of the sunlight for 24 hours before taking MELANOCYL SOLUTION 25ML. ... Be extra careful for at least 48 hours after each treatment."

Answered by AI

How do you use methoxsalen?

"For adults and children over the age of 12, apply the product to the affected area of skin and allow it to dry for one to two minutes. Then, reapply within two to two and a half hours before exposure to UV light. For children under the age of 12, dosage and frequency must be determined by a doctor."

Answered by AI

Clinical Trials for Oxsoralen

Have you considered Oxsoralen clinical trials? We made a collection of clinical trials featuring Oxsoralen, we think they might fit your search criteria.
Have you considered Oxsoralen clinical trials? We made a collection of clinical trials featuring Oxsoralen, we think they might fit your search criteria.
Have you considered Oxsoralen clinical trials? We made a collection of clinical trials featuring Oxsoralen, we think they might fit your search criteria.
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