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What is Sulindac
SulindacThe Generic name of this drug
Treatment SummarySulindac is a type of anti-inflammatory medication that is used to reduce inflammation and treat inflammatory conditions. It is sold under the brand name Clinoril and is part of a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). Sulindac is a prodrug, meaning it must be converted by the liver into an active form before it can be used by the body. Studies have suggested that sulindac may cause fewer gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. This may be because the active form of
Clinorilis the brand name
Sulindac Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Clinoril
Sulindac
1978
55
Approved as Treatment by the FDA
Sulindac, also known as Clinoril, is approved by the FDA for 7 uses such as Osteoarthritis and acute Subacromial bursitis .Osteoarthritis
acute Subacromial bursitis
acute supraspinatus tendinitis
Rheumatoid Arthritis
Tendinitis
Gouty Arthritis
Ankylosing Spondylitis
Effectiveness
How Sulindac Affects PatientsSulindac is a medication used to reduce inflammation, pain, and fever. It belongs to a type of drugs called non-steroidal anti-inflammatory drugs (NSAIDs).
How Sulindac works in the bodySulindac works to reduce inflammation, but the exact mechanism is unknown. Its effects are likely due to blocking the production of prostaglandins, which are responsible for inflammation. It may also reduce fever by increasing blood flow and causing the body to release more heat.
When to interrupt dosage
The endorsed amount of Sulindac is based upon the diagnosed condition, such as Osteoarthritis (OA), Ankylosing Spondylitis and acute supraspinatus tendinitis. The dosage is contingent upon the mode of delivery (e.g. Oral or Tablet) specified in the table below.Condition
Dosage
Administration
acute supraspinatus tendinitis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Adenomatous Polyposis Coli
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Gouty Arthritis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Colorectal Adenomas
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Osteoarthritis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Ankylosing Spondylitis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
acute Subacromial bursitis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Rheumatoid Arthritis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Tendinitis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
Sulindac ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Coronary Artery Bypass Grafting
Do Not Combine
Pulse Frequency
Do Not Combine
Common Sulindac Drug Interactions
Drug Name
Risk Level
Description
Macimorelin
Major
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Sulindac.
Methotrexate
Major
The serum concentration of Methotrexate can be increased when it is combined with Sulindac.
Mifamurtide
Major
The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Sulindac.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Neomycin.
Omacetaxine mepesuccinate
Major
The risk or severity of bleeding can be increased when Sulindac is combined with Omacetaxine mepesuccinate.
Sulindac Toxicity & Overdose RiskThe toxic dose of Lasix in rats has been found to be 264mg/kg. Signs of overdose include confusion, loss of consciousness, reduced urine output, and low blood pressure. In rare cases, death may occur.
Sulindac Novel Uses: Which Conditions Have a Clinical Trial Featuring Sulindac?
99 active trials are being conducted to assess the efficacy of Sulindac in treating Adenomatous Polyposis Coli, Osteoarthritis (OA) and Gouty Arthritis.Condition
Clinical Trials
Trial Phases
Rheumatoid Arthritis
58 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Osteoarthritis
0 Actively Recruiting
acute Subacromial bursitis
0 Actively Recruiting
Colorectal Adenomas
10 Actively Recruiting
Phase 2, Not Applicable
Adenomatous Polyposis Coli
8 Actively Recruiting
Not Applicable, Phase 2, Phase 1
acute supraspinatus tendinitis
0 Actively Recruiting
Tendinitis
0 Actively Recruiting
Ankylosing Spondylitis
3 Actively Recruiting
Phase 3, Not Applicable
Gouty Arthritis
1 Actively Recruiting
Phase 2, Phase 3
Sulindac Reviews: What are patients saying about Sulindac?
5Patient Review
10/20/2015 This prescription has been great for my bursitis-related hip pain as well as the aches in my hands. I started out taking 200mg once a day, and then increased to twice a day after three months. The tinnitus has gotten worse since starting this medication, but the benefits outweigh that side effect.
5Patient Review
11/26/2016 After years of knee pain, this treatment has finally given me some relief. I'm amazed at how well it works!
5Patient Review
4/25/2013 I got nauseous about two hours after taking this medication, followed by diarrhea and stomach pain.
5Patient Review
4/7/2014 Though I had to lower the dosage, this medicine still helped me a lot.
5Patient Review
8/2/2013 This medication has been an absolute lifesaver for my chronic leg and hip pain. I can hardly walk if I'm not taking it, and I've had no negative side effects in the two years that I've been on it.
4.3Patient Review
1/13/20124Patient Review
1/30/2021 This treatment takes a bit of time to work, but it really does help with constant pain in my back, knees, and hips. I can move around much better now!
4Patient Review
2/22/2012 For the first time in a while, I was able to wake up and grab the coffee pot with one hand. My knees didn't shake when going down stairs, and I generally felt less pain overall. I was amazed and very happy.
4Patient Review
7/23/2022 It significantly lessened the pain and inflammation I was experiencing. So far, so good!
2.3Patient Review
12/18/2012 This medication caused my urine to smell like pistachio nuts.
2Patient Review
3/4/2015 Sulindac was prescribed to me by a doctor for severe lower back pain. Unfortunately, within 24 hours I developed hives all over my body--which were intensely itchy and uncomfortable. With no other choice, I had to take cold baths every hour just to be able to function or get any rest. Thankfully, I was eventually able to get a prescription that helped shrink the hives and ease the itching.
1.7Patient Review
3/27/2013 I had to stop taking this medication after only a few days because it made my ankles swell up.
1.3Patient Review
9/10/2015 The prescribed dosage of 200mg x2 per day felt unbearable to me. It was like being stabbed with an ice pick.
Patient Q&A Section about sulindac
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is sulindac the same as ibuprofen?
"This study found that sulindac is effective in treating musculo-skeletal diseases and does not have any side-effects at the recommended dosage."
Answered by AI
What is the drug sulindac used for?
"Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and help relieve symptoms of arthritis (e.g., osteoarthritis and rheumatoid arthritis) or acute gout, such as inflammation, swelling, stiffness, and joint pain. The drug can also be used to help reduce the risk of colorectal cancer.Jun 1, 2022"
Answered by AI
Is sulindac a pain killer?
"Sulindac is a medication used to treat pain, swelling, and stiffness from arthritis. It is also used to treat arthritis of the spine, gouty arthritis, and shoulder bursitis/tendonitis. This medication is classified as a nonsteroidal anti-inflammatory drug (NSAID)."
Answered by AI
What are the side effects of taking sulindac?
"You may experience a headache, dizziness, nervousness, diarrhea, constipation, gas, or ringing in the ears."
Answered by AI