Sulindac

acute supraspinatus tendinitis, acute Subacromial bursitis, Tendinitis + 6 more
Treatment
10 FDA approvals
20 Active Studies for Sulindac

What is Sulindac

SulindacThe Generic name of this drug
Treatment SummarySulindac is a type of anti-inflammatory medication that is used to reduce inflammation and treat inflammatory conditions. It is sold under the brand name Clinoril and is part of a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). Sulindac is a prodrug, meaning it must be converted by the liver into an active form before it can be used by the body. Studies have suggested that sulindac may cause fewer gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. This may be because the active form of
Clinorilis the brand name
image of different drug pills on a surface
Sulindac Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Clinoril
Sulindac
1978
55

Approved as Treatment by the FDA

Sulindac, also known as Clinoril, is approved by the FDA for 10 uses such as Ankylosing Spondylitis (AS) and Osteoarthritis (OA) .
Ankylosing Spondylitis (AS)
Osteoarthritis (OA)
Tendonitis exacerbated
Osteoarthritis
acute Subacromial bursitis
acute supraspinatus tendinitis
Rheumatoid Arthritis
Tendinitis
Arthritis, Gouty
Ankylosing Spondylitis

Effectiveness

How Sulindac Affects PatientsSulindac is a medication used to reduce inflammation, pain, and fever. It belongs to a type of drugs called non-steroidal anti-inflammatory drugs (NSAIDs).
How Sulindac works in the bodySulindac works to reduce inflammation, but the exact mechanism is unknown. Its effects are likely due to blocking the production of prostaglandins, which are responsible for inflammation. It may also reduce fever by increasing blood flow and causing the body to release more heat.

When to interrupt dosage

The endorsed amount of Sulindac is based upon the diagnosed condition, such as Osteoarthritis (OA), Ankylosing Spondylitis and acute supraspinatus tendinitis. The dosage is contingent upon the mode of delivery (e.g. Oral or Tablet) specified in the table below.
Condition
Dosage
Administration
acute supraspinatus tendinitis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Adenomatous Polyposis Coli
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Arthritis, Gouty
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Colorectal Adenomas
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Osteoarthritis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Ankylosing Spondylitis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
acute Subacromial bursitis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Rheumatoid Arthritis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Tendinitis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Sulindac Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Coronary Artery Bypass Grafting
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Sulindac.
Common Sulindac Drug Interactions
Drug Name
Risk Level
Description
Macimorelin
Major
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Sulindac.
Methotrexate
Major
The serum concentration of Methotrexate can be increased when it is combined with Sulindac.
Mifamurtide
Major
The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Sulindac.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Neomycin.
Omacetaxine mepesuccinate
Major
The risk or severity of bleeding can be increased when Sulindac is combined with Omacetaxine mepesuccinate.
Sulindac Toxicity & Overdose RiskThe toxic dose of Lasix in rats has been found to be 264mg/kg. Signs of overdose include confusion, loss of consciousness, reduced urine output, and low blood pressure. In rare cases, death may occur.
image of a doctor in a lab doing drug, clinical research

Sulindac Novel Uses: Which Conditions Have a Clinical Trial Featuring Sulindac?

99 active trials are being conducted to assess the efficacy of Sulindac in treating Adenomatous Polyposis Coli, Osteoarthritis (OA) and Gouty Arthritis.
Condition
Clinical Trials
Trial Phases
Rheumatoid Arthritis
55 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Adenomatous Polyposis Coli
6 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Osteoarthritis
0 Actively Recruiting
acute Subacromial bursitis
0 Actively Recruiting
Colorectal Adenomas
10 Actively Recruiting
Phase 2, Not Applicable, Phase 1
acute supraspinatus tendinitis
0 Actively Recruiting
Tendinitis
0 Actively Recruiting
Ankylosing Spondylitis
3 Actively Recruiting
Phase 3, Not Applicable
Arthritis, Gouty
0 Actively Recruiting

Sulindac Reviews: What are patients saying about Sulindac?

5Patient Review
10/20/2015
Sulindac for Inflammation of the Sac Surrounding the Joint - Bursitis
This prescription has been great for my bursitis-related hip pain as well as the aches in my hands. I started out taking 200mg once a day, and then increased to twice a day after three months. The tinnitus has gotten worse since starting this medication, but the benefits outweigh that side effect.
5Patient Review
11/26/2016
Sulindac for Joint Damage causing Pain and Loss of Function
After years of knee pain, this treatment has finally given me some relief. I'm amazed at how well it works!
5Patient Review
4/25/2013
Sulindac for Gout
I got nauseous about two hours after taking this medication, followed by diarrhea and stomach pain.
5Patient Review
4/7/2014
Sulindac for Joint Damage causing Pain and Loss of Function
Though I had to lower the dosage, this medicine still helped me a lot.
5Patient Review
8/2/2013
Sulindac for Inflammation of the Tendon
This medication has been an absolute lifesaver for my chronic leg and hip pain. I can hardly walk if I'm not taking it, and I've had no negative side effects in the two years that I've been on it.
4.3Patient Review
1/13/2012
Sulindac for Rheumatoid Arthritis
4Patient Review
1/30/2021
Sulindac for Rheumatic Disease causing Pain & Stiffness in Backbone
This treatment takes a bit of time to work, but it really does help with constant pain in my back, knees, and hips. I can move around much better now!
4Patient Review
2/22/2012
Sulindac for Joint Damage causing Pain and Loss of Function
For the first time in a while, I was able to wake up and grab the coffee pot with one hand. My knees didn't shake when going down stairs, and I generally felt less pain overall. I was amazed and very happy.
4Patient Review
7/23/2022
Sulindac for Inflammation of the Covering of the Tendon
It significantly lessened the pain and inflammation I was experiencing. So far, so good!
2.3Patient Review
12/18/2012
Sulindac for Inflammation of a Shoulder Joint
This medication caused my urine to smell like pistachio nuts.
2Patient Review
3/4/2015
Sulindac for Joint Damage causing Pain and Loss of Function
Sulindac was prescribed to me by a doctor for severe lower back pain. Unfortunately, within 24 hours I developed hives all over my body--which were intensely itchy and uncomfortable. With no other choice, I had to take cold baths every hour just to be able to function or get any rest. Thankfully, I was eventually able to get a prescription that helped shrink the hives and ease the itching.
1.7Patient Review
3/27/2013
Sulindac for Inflammation of the Tendon
I had to stop taking this medication after only a few days because it made my ankles swell up.
1.3Patient Review
9/10/2015
Sulindac for Joint Damage causing Pain and Loss of Function
The prescribed dosage of 200mg x2 per day felt unbearable to me. It was like being stabbed with an ice pick.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about sulindac

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is sulindac the same as ibuprofen?

"This study found that sulindac is effective in treating musculo-skeletal diseases and does not have any side-effects at the recommended dosage."

Answered by AI

What is the drug sulindac used for?

"Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and help relieve symptoms of arthritis (e.g., osteoarthritis and rheumatoid arthritis) or acute gout, such as inflammation, swelling, stiffness, and joint pain. The drug can also be used to help reduce the risk of colorectal cancer.Jun 1, 2022"

Answered by AI

Is sulindac a pain killer?

"Sulindac is a medication used to treat pain, swelling, and stiffness from arthritis. It is also used to treat arthritis of the spine, gouty arthritis, and shoulder bursitis/tendonitis. This medication is classified as a nonsteroidal anti-inflammatory drug (NSAID)."

Answered by AI

What are the side effects of taking sulindac?

"You may experience a headache, dizziness, nervousness, diarrhea, constipation, gas, or ringing in the ears."

Answered by AI

Clinical Trials for Sulindac

Image of Sunnybrook Health Sciences Centre in Toronto, Canada.

Steroids for Rheumatoid Arthritis

18+
All Sexes
Toronto, Canada
People living with rheumatoid arthritis (RA) often experience flares-periods where their symptoms suddenly get worse. These flares can cause significant pain, make it harder to move and do daily activities, and lower overall quality of life. Doctors often treat flares with medications called glucocorticoids (GCs), which reduce inflammation. These medications can be taken by mouth (oral/PO) or given as a single injection into the muscle (intramuscular/IM). However, it's not clear which option works better from the patient's point of view-especially when it comes to relief of symptoms, improvements in function, and satisfaction with treatment. Most research so far has focused on how well the drugs control the disease, rather than how they impact the patient's overall experience. Research Questions: 1. Does a single GC injection work just as well as taking pills over a few weeks in improving symptoms reported by patients? 2. How do the two treatments compare in terms of symptom relief, ability to function, and patient satisfaction? 3. What do patients think and feel about using GCs to treat RA flares? What the Investigators Think: The investigators believe that a one-time GC injection is just as good as taking pills for a few weeks when it comes to managing RA flares. In fact, the injection might even be safer and preferred by patients. What the Investigators are Doing: The investigators will study 220 adults with RA who are currently having a flare (with at least 3 swollen and tender joints). These patients will be recruited from rheumatology clinics at the University of Toronto and must not have used GCs in the past month. They will be randomly assigned to receive either: A single injection (Methylprednisolone 120 mg), or Oral pills (Prednisone starting at 15 mg daily and tapering down over 3 weeks). The main thing the investigators will look at is how much better patients feel after 6 weeks, based on a questionnaire designed to measure RA flares. The investigators will also look at how well they function, how satisfied they are with the treatment, and whether they had any side effects. In addition, 20 patients (10 from each group) will be interviewed to understand their experiences and opinions about flare treatment in more detail. Why This Is Possible: The investigators have already surveyed University of Toronto rheumatologists who support the idea and provided input on study design. The investigators have also partnered with experts in research methods, national arthritis organizations, and patient groups to make sure the study is relevant and meaningful. Ethics approval has been obtained. Why It Matters: RA flares can have a major impact on people's lives. While current treatments help control inflammation, the investigators need to better understand how these treatments affect people from their own perspective. This study will shift the focus to what matters most to patients, helping doctors and patients choose the best treatment based not only on medical results but also on the patient's experience. This could lead to more effective and personalized care for people living with RA.
Phase 4
Waitlist Available
Sunnybrook Health Sciences Centre (+4 Sites)
Image of California Clinical Trials Medical Group in Glendale, United States.

NTR-1011 for Lupus and Rheumatoid Arthritis

18 - 75
All Sexes
Glendale, CA
This phase 1a and 1b study is designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary efficacy of NTR-1011 in healthy adults and in adult patients with systemic lupus erythematosus and rheumatoid arthritis. The main goals of this study are to determine the safety profile of NTR-1011 across subcutaneous and intravenous dose levels, understand how the drug behaves in the body, characterize its biological activity through relevant pharmacodynamic markers, assess the potential for immune responses to treatment, and explore early signals of clinical benefit in autoimmune disease settings. This is a randomized, double blind, placebo controlled study that begins with a single ascending dose evaluation in healthy volunteers followed by a multiple dose assessment in patients. The design is intended to define the highest safe and well tolerated dose, establish a robust PK and PD baseline, and generate initial patient level evidence to support dose selection and advancement into subsequent clinical development.
Phase 1
Recruiting
California Clinical Trials Medical GroupHakop Gevorkyan, MDNeutrolis
Image of Weill Cornell Medical College in New York, United States.

Health Coaching for Rheumatoid Arthritis

18+
All Sexes
New York, NY
The goal of this clinical trial is to learn if peer coaching works to reduce levels of anxiety and/or depression in adults diagnosed with Rheumatoid Arthritis (RA). The main questions it aims to answer are: Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months from baseline? Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months compared to those in the control arm? Researchers will compare the peer coaching intervention to an active-control arm (where people without RA coach participants on general health and nutrition topics) to see if peer coaching works to reduce anxiety and/or depression. Participants will meet with a coach every week for 9 weeks and complete several surveys before, during and after the intervention
Recruiting
Has No Placebo
Weill Cornell Medical CollegeIris Y Navarro-Millán, MDBristol-Myers Squibb
Have you considered Sulindac clinical trials? We made a collection of clinical trials featuring Sulindac, we think they might fit your search criteria.Go to Trials
Image of Truway Health, Inc. www.truwayhealth.com (401 E 34th Street, S11P, New York, NY 10016) in New York, United States.

Electromagnetic Resonance Therapy for Autoimmune Diseases

Any Age
All Sexes
New York, NY
The ImmuneNet study is a Phase I/II clinical trial sponsored by Truway Health, Inc. It will test whether gentle, low-frequency electromagnetic resonance (LF-EMR) can influence how immune cells communicate and synchronize with each other. The goal is to see if this "quantum-synaptic" signaling effect can help stabilize immune activity and reduce the number of autoimmune flare-ups in people living with conditions such as lupus, rheumatoid arthritis, or multiple sclerosis. Participants will receive either an active or a sham (placebo) LF-EMR session three times per week for twelve weeks. Each session is completely non-invasive. Blood samples will be collected to study cytokines (immune-system messenger molecules), gene-expression patterns, and electrical field coherence among immune cells. A machine-learning system will analyze these data to predict inflammation patterns and guide individualized treatment settings. All participant data will be securely recorded and time-stamped to ensure transparency and privacy. The expected outcome of the study is a measurable reduction in autoimmune flare frequency and symptom severity, along with improved understanding of how electromagnetic signaling might safely regulate immune function.
Phase 1 & 2
Waitlist Available
Truway Health, Inc. www.truwayhealth.com (401 E 34th Street, S11P, New York, NY 10016)Gavin Solomon, President & CEOTruway Health, Inc.
Image of University of Minnesota Medical School, Division of Rheumatic and Autoimmune Diseases in Minneapolis, United States.

Ultrasound Therapy for Rheumatoid Arthritis

18+
All Sexes
Minneapolis, MN
The At-Home ULTRA Study will evaluate performance of the MINI system as indicated for the treatment of adults with active, moderate to severe rheumatoid arthritis who are inadequate responders or are intolerant to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), biologic DMARDs (bDMARDs), or targeted synthetic DMARDs (tsDMARDs). The non-invasive study device delivers ultrasound stimulation to the spleen to reduce inflammation. The study will enroll at least 60 participants at up to 8 sites. There will be three arms consisting of two active stimulation groups (treatment) and one non-active stimulation group (sham-control). After completing the double-blinded primary endpoint assessment period at Week 12, there will be a one-way crossover of control participants to active stimulation and an additional 12 week follow-up with all participants to evaluate long-term outcomes.
Recruiting
Drug
University of Minnesota Medical School, Division of Rheumatic and Autoimmune DiseasesDaniel ZachsSecondWave Systems Inc.
Have you considered Sulindac clinical trials? We made a collection of clinical trials featuring Sulindac, we think they might fit your search criteria.Go to Trials
Image of St. Lawrence Health in Potsdam, United States.

Primary Care for Rheumatoid Arthritis

18+
All Sexes
Potsdam, NY
Rheumatoid arthritis (RA) is a complex autoimmune disease where the immune system attacks healthy joint tissue; causing pain, swelling, and stiffness of the joints. This disease effects lots of people in the US and can lead to major joint damage if not properly treated. In rural areas like northern NY, these are underserved areas for RA patients, thus many patients struggle to get the appropriate care. This model is testing whether primary care providers (PCP) can safely and effectively provide stable RA patients with the proper treatment rather than send them to a specialist. PCPs were trained through classes, case reviews, and a final exam. Patients will be randomly assigned to either see a trained PCP or their normal rheumatologist at the rheumatology clinic. This study will examine how patients are doing over a year using medical exams and patient feedback. If this model proves to be successful, it will make RA treatment easier and more affordable for patients.
Recruiting
Has No Placebo
St. Lawrence HealthEyal Kedar, MD
Image of Pender Community Health Centre in Vancouver, Canada.

Personalized Outreach for Rheumatic Diseases

18+
All Sexes
Vancouver, Canada
The primary goal of this study is to determine whether providing patient honoraria and/or outreach services can improve the attendance rate of appointments at an inner city rheumatology clinic in Vancouver, British Columbia. The main question it aims to answer are: * Does providing a financial honorarium ($20 for each follow-up appointment with completed bloodwork) improve attendance rate at an inner city rheumatology clinic? * Does providing a personalized outreach service for rheumatic diseases improve attendance rate at an inner city rheumatology clinic? The researchers will compare providing patient honoraria to providing both honoraria and outreach services, and compare each of these to the regular appointment schedule without honoraria or outreach. Participants will: * Undergo randomization to receive honoraria or honoraria and outreach services together * Complete surveys about their health and understanding of their rheumatic disease at baseline, 3-month, and 6-month intervals * Visit the clinic every month for check-ups and monitoring bloodwork if they are started on immunosuppressants for their condition
Waitlist Available
Has No Placebo
Pender Community Health CentreBrent R Ohata, MD
Have you considered Sulindac clinical trials? We made a collection of clinical trials featuring Sulindac, we think they might fit your search criteria.Go to Trials
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