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What is Tadalafil
TadalafilThe Generic name of this drug
Treatment SummaryTadalafil is a medication used to treat erectile dysfunction, pulmonary arterial hypertension, and enlarged prostate. It was approved by the FDA in 2003 for erectile dysfunction and 2009 for pulmonary arterial hypertension. Tadalafil is more selective than other similar drugs, such as sildenafil, and has a longer half-life which makes it suitable for chronic daily dosing in the treatment of pulmonary arterial hypertension.
Cialisis the brand name
Tadalafil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cialis
Tadalafil
2003
295
Approved as Treatment by the FDA
Tadalafil, commonly known as Cialis, is approved by the FDA for 3 uses including Impotence and Pulmonary Arterial Hypertension .Impotence
Helps manage Erectile Dysfunction
Pulmonary Arterial Hypertension
Helps manage Pulmonary Arterial Hypertension (PAH)
Enlarged Prostate
Effectiveness
How Tadalafil Affects PatientsTadalafil helps treat erectile dysfunction by increasing blood flow to the penis. It also helps reduce blood pressure in the blood vessels of the lungs for people with PAH and may help reduce the size of the prostate and related urinary symptoms in people with BPH. It is less likely to cause visual side effects than other drugs that help treat ED.
How Tadalafil works in the bodyTadalafil is an effective drug for treating erectile dysfunction, pulmonary arterial hypertension, and benign prostatic hyperplasia. It works by increasing the signaling of nitric oxide and cyclic guanosine monophosphate (cGMP) in the body. This signaling relaxes smooth muscle cells, allowing blood to flow more freely and produce an erection. In pulmonary arterial hypertension, tadalafil relaxes the muscles of the arteries, reducing pressure and easing symptoms. In benign prostatic hyperplasia, it reduces inflammation and tissue remodeling, which can help improve urinary flow. Tadalafil has a
When to interrupt dosage
The suggested dosage of Tadalafil is contingent upon the diagnosed state, including Impotence, Pulmonary Arterial Hypertension and Enlarged Prostate. The measure of dosage is outlined in the table below, based on the technique of delivery (e.g. Tablet, film coated - Oral or Tablet).Condition
Dosage
Administration
Enlarged Prostate
, 10.0 mg, 20.0 mg, 5.0 mg, 2.5 mg, 40.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Capsule - Oral, Capsule
Pulmonary Arterial Hypertension
, 10.0 mg, 20.0 mg, 5.0 mg, 2.5 mg, 40.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Capsule - Oral, Capsule
Impotence
, 10.0 mg, 20.0 mg, 5.0 mg, 2.5 mg, 40.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Capsule - Oral, Capsule
Warnings
Tadalafil has two counterindications. It should not be administered concurrently with the conditions demonstrated in the following table.Tadalafil ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Common Tadalafil Drug Interactions
Drug Name
Risk Level
Description
Alprostadil
Major
The risk or severity of hypotension and priapism can be increased when Tadalafil is combined with Alprostadil.
Amifostine
Major
Tadalafil may increase the hypotensive activities of Amifostine.
Amyl Nitrite
Major
The risk or severity of hypotension can be increased when Tadalafil is combined with Amyl Nitrite.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Tadalafil.
Avanafil
Major
The risk or severity of adverse effects can be increased when Tadalafil is combined with Avanafil.
Tadalafil Toxicity & Overdose RiskOverdosing on tadalafil may cause symptoms such as headache, indigestion, back pain, muscle pain, congestion in the nose or throat, and dizziness. Standard medical care should be provided. Hemodialysis will not be very effective at removing the drug from the body.
Tadalafil Novel Uses: Which Conditions Have a Clinical Trial Featuring Tadalafil?
95 active clinical trials are presently underway to explore the potential of Tadalafil to address Impotence, Pulmonary Arterial Hypertension and Enlarged Prostate Disorders.Condition
Clinical Trials
Trial Phases
Pulmonary Arterial Hypertension
5 Actively Recruiting
Phase 1, Not Applicable, Phase 2
Enlarged Prostate
21 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Phase 3
Impotence
22 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3
Tadalafil Reviews: What are patients saying about Tadalafil?
5Patient Review
7/6/2022 For a tiny weekly price, I've been getting more erections than ever before. It's fantastic to feel healthy and happy again. If you're considering this treatment, I say go for it!
5Patient Review
8/5/2022 I'm so glad that Johnny Depp is the new face of Tadalafil / Cialis. It's great that somebody with such a high profile is willing to talk about ED openly. I hope this helps normalize the conversation around erectile dysfunction and lets people know that there are treatments available.
5Patient Review
9/25/2022 This drug has been helping me for a while now. It's the best because it doesn't cause headaches like other drugs do. Once I took it, I remained hard for up to four days. I've even recommended it to friends—it really is the best.
5Patient Review
6/21/2022 I'm extremely happy with the results of this treatment. I feel healthy and virile again, and at such a low cost!
2.7Patient Review
9/7/2021 I began with the 10mg dose but found it ineffective. I was then prescribed 20mg, but still saw no significant improvement in my condition.
2.3Patient Review
1/15/2021 I took 5mg daily for BPH but stopped after a week because the severe back and leg pain, calf tightness, and reflux at night were too many side effects. It worked to address the mild symptoms I had but at too high of a cost.
2.3Patient Review
5/15/2022 I've been taking these pills for about three weeks now in the hopes that they would help me with my erectile dysfunction. Unfortunately, I have seen zero results. To me, it seems like this is just a way for the company to make money.
2.3Patient Review
1/16/2022 Worked decently, but the pain it caused in my lower back was unbearable.
2Patient Review
4/7/2022 I tried this treatment four times, taking 20mg pills each time. Unfortunately, it didn't work for me. I was hoping it would help me get a full erection, but that didn't happen.
1.7Patient Review
6/8/2022 I would not recommend this product to anyone. I was taking 10 mg before they boosted it up to 20 mg because it wasn't working properly and let me tell you, this is the worst medicine I have ever taken for treatment. It caused me more pain than anything in my joints, muscles, back, legs, shoulders - everywhere. They should really take this off the market; it's not worth the price or the pain.
Patient Q&A Section about tadalafil
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long does tadalafil last after taking?
"Tadalafil lasts for up to 36 hours, which is longer than other PDE5 inhibitors."
Answered by AI
What happens after taking tadalafil?
"By controlling the enzyme, tadalafil helps to maintain an erection by increasing blood flow to the penis after the penis is stroked. Without physical action to the penis, such as that occurring during sexual intercourse, tadalafil will not work to cause an erection."
Answered by AI
What are the dangers of tadalafil?
"The following symptoms may be experienced: arm, back, or jaw pain; chest pain, discomfort, tightness, or heaviness; cold sweats; faintness or lightheadedness when getting up suddenly from a lying or sitting position; fast or irregular heartbeat; increased erection; pain or discomfort in the arms, jaw, back, or neck; pounding in the ears."
Answered by AI
What does tadalafil do for a man?
"Tadalafil is a prescription medication used to treat erectile dysfunction, enlarged prostate, and high blood pressure in the lungs."
Answered by AI