Tri-Linyah

Acne Vulgaris, moderate Vulvovaginal atrophy, Hot flashes + 9 more
Treatment
8 FDA approvals
20 Active Studies for Tri-Linyah

What is Tri-Linyah

NorgestimateThe Generic name of this drug
Treatment SummaryEthinylestradiol is a synthetic form of the hormone estrogen that was first developed in 1938. It was designed to be more easily absorbed when taken orally than other forms of estrogen. As a result, it soon became the main form of estrogen used in contraceptive pills. Ethinylestradiol was approved by the FDA in 1943 and is still widely used today.
Ortho Tri Cyclenis the brand name
image of different drug pills on a surface
Tri-Linyah Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ortho Tri Cyclen
Norgestimate
1989
113

Approved as Treatment by the FDA

Norgestimate, commonly known as Ortho Tri Cyclen, is approved by the FDA for 8 uses which include Oral Contraceptives and Osteoporosis, Postmenopausal .
Oral Contraceptives
Used to treat Oral Contraceptives in combination with Ethinylestradiol
Osteoporosis, Postmenopausal
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
Acne Vulgaris
Used to treat moderate Acne vulgaris in combination with Ethinylestradiol
moderate Vulvovaginal atrophy
Used to treat moderate Vulvovaginal atrophy in combination with Estradiol
Hot flashes
Used to treat Menopause in combination with Estradiol
moderate Menopausal Vasomotor Symptoms
Used to treat moderate Menopausal Vasomotor Symptoms in combination with Estradiol
Menopause
Used to treat severe Vasomotor Symptoms Associated With Menopause in combination with Estradiol
severe menopausal vulvovaginal atrophy
Used to treat severe menopausal vulvovaginal atrophy in combination with Estradiol

Effectiveness

How Tri-Linyah Affects PatientsEthinylestradiol is a synthetic hormone that helps to prevent ovulation and reduce the growth of the lining of the womb. It is taken once daily and is considered to be a safe drug. However, patients should be aware that there is a risk of blood clots occurring when taking this medication.
How Tri-Linyah works in the bodyEthinylestradiol is a synthetic form of estrogen. Taking it can help reduce the chance of pregnancy by stopping ovulation, making it harder for sperm to travel, and preventing changes in the uterus. It also reduces luteinizing hormone and increases sex hormone binding globulin. All of these effects make it harder for a fertilized egg to implant in the uterus.

When to interrupt dosage

The amount of Tri-Linyah is contingent upon the diagnosed affliction, including Acne Vulgaris, Hormonal Contraception and Folate supplementation therapy. The degree of dosage shifts as per the delivery approach featured in the table beneath.
Condition
Dosage
Administration
Polycystic Ovarian Syndrome
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
moderate Vulvovaginal atrophy
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Menopause
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
severe menopausal vulvovaginal atrophy
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Osteoporosis, Postmenopausal
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Oral Contraceptives
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Menorrhagia
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Hirsutism
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
moderate Menopausal Vasomotor Symptoms
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Hot flashes
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Acne Vulgaris
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Dysmenorrhea
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral

Warnings

Tri-Linyah Contraindications
Condition
Risk Level
Notes
Breast
Do Not Combine
Breast Cancer
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Hypersensitivity
Do Not Combine
Venous Thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
Metrorrhagia
Do Not Combine
Liver Neoplasms
Do Not Combine
There are 20 known major drug interactions with Tri-Linyah.
Common Tri-Linyah Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Norgestimate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Norgestimate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Norgestimate.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Norgestimate.
Astemizole
Major
The metabolism of Astemizole can be increased when combined with Norgestimate.
Tri-Linyah Toxicity & Overdose RiskWomen who overdose on birth control may experience irregular bleeding, nausea, vomiting, breast discomfort, abdominal pain, drowsiness, and exhaustion. Treatment of this overdose should include watching for changes in potassium and sodium levels, as well as signs of metabolic acidosis.
image of a doctor in a lab doing drug, clinical research

Tri-Linyah Novel Uses: Which Conditions Have a Clinical Trial Featuring Tri-Linyah?

38 active studies are currently being conducted to investigate the potential of Tri-Linyah as a therapeutic intervention for Folate supplementation therapy, Premenstrual Dysphoric Disorder and Menopause.
Condition
Clinical Trials
Trial Phases
Dysmenorrhea
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Osteoporosis, Postmenopausal
0 Actively Recruiting
Oral Contraceptives
2 Actively Recruiting
Not Applicable
Menopause
0 Actively Recruiting
Polycystic Ovarian Syndrome
8 Actively Recruiting
Not Applicable, Early Phase 1, Phase 4, Phase 1
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Hirsutism
0 Actively Recruiting
Hot flashes
13 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Early Phase 1
moderate Vulvovaginal atrophy
0 Actively Recruiting
Menorrhagia
0 Actively Recruiting
severe menopausal vulvovaginal atrophy
0 Actively Recruiting

Tri-Linyah Reviews: What are patients saying about Tri-Linyah?

5Patient Review
4/15/2016
Tri-Linyah for Birth Control
I've been on this pill for almost 4 months now and haven't had a single side effect. All the reviews I read terrified me but I'm totally fine.
5Patient Review
8/9/2019
Tri-Linyah for Absence of Menstrual Periods
I've been taking this birth control for nearly five years and I'm very pleased. My period is regular, my cramps aren't as bad, and it's helped clear up my acne significantly.
4.3Patient Review
9/28/2018
Tri-Linyah for Birth Control
The only downside to this birth control that I've noticed is that it's given me acne. Other than that, it's been great! It's shortened and lightened my periods as well as reducing cramping. Unless something changes, I'll definitely keep taking it.
4.3Patient Review
1/30/2019
Tri-Linyah for Birth Control
My acne has calmed down, but I've been spotting for more than two weeks now. It's frustrating because it feels like I'm on an endless period. I don't think I'll continue taking this birth control pill; it might work for others but not for my body.
4Patient Review
2/7/2018
Tri-Linyah for Painful Periods
This treatment has made my periods much more bearable. I used to be in a lot of pain and now it's only for a day or so. I've also noticed that my skin is better. However, I am always very moody, nauseous, and have gained weight. My breasts have gone from a C cup to a double or triple D cup. I get migraines quite often too. The most frustrating part for me is the weight gain; I feel fat and ugly. I've gained about 17 pounds since starting this medication.
3.7Patient Review
2/5/2017
Tri-Linyah for Birth Control
I've been on this medication for six months now and have noticed some very concerning changes in my mood and behavior. I'm also vomiting more frequently than before.
3.3Patient Review
1/4/2018
Tri-Linyah for Birth Control
I've noticed an increase in my vaginal discharge since switching to this birth control, which is normal. However, it's more than I had before and can be a bit inconvenient.
3.3Patient Review
9/28/2017
Tri-Linyah for Birth Control
I unfortunately found that this medication made my migraines worse and cramps more severe.
3Patient Review
6/10/2018
Tri-Linyah for Birth Control
While this pill did prevent pregnancy, it was not worth the daily hunger, bloating, and spotting. My hormones were all over the place while I was taking this pill, and I would never recommend it to anyone.
2.7Patient Review
2/25/2016
Tri-Linyah for Birth Control
While this medication did prevent pregnancy, I was definitely not a fan of the side effects. Bloating, anxiety, depression, mood swings, migraines and bad acne made me feel like I was undergoing puberty from hell. The upside is that my sex drive increased and my boobs got bigger.
2.7Patient Review
8/8/2017
Tri-Linyah for Birth Control
I haven't become pregnant yet, but I find this birth control pill to have several negative side effects. The biggest issue is that I'm bleeding much more heavily and for longer periods of time. I've also had pretty severe cramping which radiates into my lower back. One month my period came early which is NOT supposed to happen on birth control, and this month it is still going 3 days after I have started the next pack. Overall, I would not suggest this product to others.
2Patient Review
1/31/2017
Tri-Linyah for Birth Control
I'm pregnant with my fourth child because this medication didn't work for me.
1.7Patient Review
5/3/2017
Tri-Linyah for Abnormally Long or Heavy Periods
I would not recommend this pill to anyone. It was supposed to help regulate my heavy periods but instead I bled for the entire two months I was on it. Plus, I had anxiety, nausea and vomiting, and insomnia. Once I stopped taking the pill, all of those symptoms went away.
1Patient Review
11/3/2016
Tri-Linyah for Birth Control
I would not recommend this pill to anyone. It's made my acne so much worse and I've only been taking it for 1 1/2 months.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tri-linyah

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does Tri-Linyah cause weight gain?

"While taking Tri-Linyah and other birth control pills, some women may experience weight gain. The hormones in the pills have a chance of giving the women the munchies; however, the weight gain is mostly from water retention and not actual fat."

Answered by AI

What are side effects of Tri-Linyah?

"If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Nausea, vomiting, headache, bloating, breast tenderness, and weight change may occur. Vaginal bleeding may occur, especially during the first few months of use. If any of these effects persist or worsen, tell your doctor or pharmacist promptly."

Answered by AI

Is Tri-Linyah the same as Ortho Tri Cyclen?

"is indicated for the prevention of pregnancy in women who elect to use oral contraceptives as a method of contraception.

ORTHO TRI-CYCLEN is a medication that is used to prevent pregnancy. It is a birth control pill that is taken by mouth."

Answered by AI

What kind of birth control is Tri-Linyah?

"Tri-Linyah is a combination oral contraceptive pill containing the progestational compound norgestimate and the estrogenic compound ethinyl estradiol."

Answered by AI

Clinical Trials for Tri-Linyah

Have you considered Tri-Linyah clinical trials? We made a collection of clinical trials featuring Tri-Linyah, we think they might fit your search criteria.
Have you considered Tri-Linyah clinical trials? We made a collection of clinical trials featuring Tri-Linyah, we think they might fit your search criteria.
Image of University of Colorado Anschutz Medical Center, Clinical Translational Research Center and Exercise Research Laboratory in Aurora, United States.

MitoQ + Exercise for Menopause-Related Vascular Health

50 - 120
Female
Aurora, CO
This trial tests whether combining moderate aerobic exercise with the antioxidant MitoQ can improve blood vessel function in postmenopausal women who lack estrogen. MitoQ aims to reduce oxidative stress and enhance blood flow by improving mitochondrial function. The study will compare the effects of exercise with MitoQ, exercise alone, and MitoQ alone. MitoQ is a mitochondria-targeted antioxidant that has been studied for its potential to enhance exercise-induced muscle adaptations and improve peak power in untrained middle-aged men.
Phase < 1
Waitlist Available
University of Colorado Anschutz Medical Center, Clinical Translational Research Center and Exercise Research LaboratoryKerrie L Moreau, PhD
Have you considered Tri-Linyah clinical trials? We made a collection of clinical trials featuring Tri-Linyah, we think they might fit your search criteria.