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What is Urecholine
BethanecholThe Generic name of this drug
Treatment SummaryBethanechol is a synthetic chemical that mimics the effects of acetylcholine, an important neurotransmitter in the parasympathetic nervous system. It is primarily used to treat urinary retention after childbirth or surgery. Bethanechol is more long-lasting than acetylcholine, because it is not broken down by cholinesterase enzymes.
Bethanechol Chlorideis the brand name
Urecholine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Bethanechol Chloride
Bethanechol
1990
100
Approved as Treatment by the FDA
Bethanechol, also called Bethanechol Chloride, is approved by the FDA for 3 uses which include acute post-operative Urinary retention and Urinary Bladder, Neurogenic .acute post-operative Urinary retention
Urinary Bladder, Neurogenic
Urinary Retention
Effectiveness
How Urecholine Affects PatientsBethanechol works by targeting only muscarinic receptors. The special structure of the drug prevents it from entering the brain, so it does not cause any side effects related to the central nervous system.
How Urecholine works in the bodyBethanechol is a drug that stimulates the parasympathetic nervous system. It does this by connecting to specific receptors in the body, known as M3 receptors. These receptors are found in the bladder and intestines, and when activated, they can help to empty the bladder and restore normal digestion. Bethanechol specifically targets M3 receptors, without having an effect on other types of receptors, so it has minimal side effects.
When to interrupt dosage
The recommended dosage of Urecholine is contingent upon the diagnosed condition, such as non-obstructive postpartum urinary retention, acute post-operative Urinary retention and neurogenic atony of the urinary bladder. The measure of dosage shifts as per the administration mode noted in the accompanying table.Condition
Dosage
Administration
acute post-operative Urinary retention
, 5.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 5.0 mg/mL
, Oral, Tablet, Tablet - Oral, Subcutaneous, Liquid, Liquid - Subcutaneous
Urinary Retention
, 5.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 5.0 mg/mL
, Oral, Tablet, Tablet - Oral, Subcutaneous, Liquid, Liquid - Subcutaneous
Urinary Bladder, Neurogenic
, 5.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 5.0 mg/mL
, Oral, Tablet, Tablet - Oral, Subcutaneous, Liquid, Liquid - Subcutaneous
Warnings
Urecholine ContraindicationsCondition
Risk Level
Notes
Urinary Bladder Neck Obstruction
Do Not Combine
Peptic Ulcer
Do Not Combine
Vagotonia
Do Not Combine
Asthma
Do Not Combine
Bradycardia
Do Not Combine
Gastrointestinal Diseases
Do Not Combine
Mechanical Intestinal Obstruction
Do Not Combine
unknown bladder wall integrity
Do Not Combine
Urinary Bladder
Do Not Combine
Gastrointestinal tract structure
Do Not Combine
Urinary Bladder
Do Not Combine
Spastic gastrointestinal disturbances
Do Not Combine
Coronary Disease
Do Not Combine
Hypotension
Do Not Combine
Hyperthyroidism
Do Not Combine
Parkinson Disease
Do Not Combine
Asthma
Do Not Combine
Epilepsy
Do Not Combine
Peritonitis
Do Not Combine
Common Urecholine Drug Interactions
Drug Name
Risk Level
Description
Cimetropium
Moderate
Bethanechol may decrease the anticholinergic activities of Cimetropium.
Urecholine Toxicity & Overdose RiskSymptoms of an overdose of bethanechol include nausea, vomiting, stomach pain, drooling, excessive sweating, and redness of the skin. In case of an overdose, atropine sulfate can be used as an antidote. For adults, a dose of 0.6 mg is recommended, while for children up to 12 years of age, a dose of 0.01 mg/kg is recommended (maximum single dose = 0.4 mg). The lethal dose of bethanechol in mice is 1510 mg/kg.
Urecholine Novel Uses: Which Conditions Have a Clinical Trial Featuring Urecholine?
Zero active clinical trials are currently assessing the potential of Urecholine to mitigate neurogenic atony of the urinary bladder, non-obstructive postpartum urinary retention and acute post-operative Urinary retention.Condition
Clinical Trials
Trial Phases
acute post-operative Urinary retention
0 Actively Recruiting
Urinary Bladder, Neurogenic
0 Actively Recruiting
Urinary Retention
16 Actively Recruiting
Phase 1, Phase 2, Phase 4, Not Applicable, Phase 3, Early Phase 1
Urecholine Reviews: What are patients saying about Urecholine?
5Patient Review
3/22/2009 I've used this drug for five years, and after recently increasing the dosage from one to three per day, I experienced most of the listed side effects. The benefits simply aren't worth put up with these negative health consequences.
5Patient Review
3/7/2011 I'm so glad this medication not only helped with my stomach issues, but also my bladder function! It's really great to have a one-stop solution like this.
5Patient Review
5/19/2012 This medication has allowed me to live a much more normal life. I no longer have to worry about being close to a restroom at all times, and the minor side effects are well worth it.
5Patient Review
11/14/2013 Bethenechol has been the only medication that's worked for me since 2000. I've tried other brands and generics, but this one from Amneal is the best. If you're having trouble with other brands, give this one a shot.
4Patient Review
12/18/2010 I've been taking this medication for about a week and have had fewer issues with bathroom trips and traveling. I'm not sure if my bladder is emptying better, but there's definitely been an improvement.
4Patient Review
9/12/2010 I've found that I don't have to go to the washroom as frequently, and when I do go, I don't feel like I need to stay there as long. This medication has definitely helped me out.
3.3Patient Review
7/20/2013 This medication helps me digest my food properly.
2.3Patient Review
11/25/2008 The manufacturer of this drug has changed the pill to a flat yellow one that is very difficult to work with. It breaks easily and crumbles to powder, making it hard to get the recommended dose.
2Patient Review
10/19/20081.7Patient Review
9/29/20081.3Patient Review
1/10/2009 I completely agree with the first reviewer. The tablet is very flimsy and easily turns to powder. Additionally, it made my husband's urine much more cloudy and thick. We saw no improvement in quantity either.
Patient Q&A Section about urecholine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the generic name for Urecholine?
"Urecholine is a medication used to treat urinary retention and bladder issues. It works by increasing the activity of a certain neurotransmitter in the body, which helps to improve muscle function in the bladder. This can help to relieve the symptoms of urinary retention and improve the overall function of the bladder."
Answered by AI
What drug class is Urecholine?
"Urecholine is a cholinergic agent, which helps muscles work to empty urine from the bladder."
Answered by AI
What is Urecholine used for?
"The medication is used to treat bladder problems, such as the inability to urinate or to empty the bladder completely. The medication works by improving the ability of the bladder muscle to squeeze, thereby improving the individual's ability to urinate."
Answered by AI
How long does it take for Urecholine to work?
"Give this medication on an empty stomach, unless vomiting occurs. If vomiting does occur, give future doses of the medication with food. Be careful when measuring liquid forms of the medication. The medication will take effect quickly, in about 1 to 2 hours. After taking the medication, you should see an improvement in clinical signs."
Answered by AI