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Opioid Analgesic

Fentanyl vs. Morphine for Platelet Reactivity

Phase < 1
Recruiting
Research Sponsored by Spectrum Health - Lakeland
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Administered aspirin within 30 minutes of the initial blood draw
Be older than 18 years old
Must not have
Patients already on aspirin, clopidogrel, or stronger anti-coagulants
Inability to provide consent in English
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 hours
Awards & highlights
No Placebo-Only Group

Summary

This trial is studying whether fentanyl & morphine have similar effects on aspirin's effect on platelets in chest pain patients in the ER.

Who is the study for?
This trial is for adults in the emergency department with chest discomfort who are undergoing specific heart tests, have taken aspirin recently, and arrived by private vehicle. It's not for those already on certain blood thinners, pregnant women, chronic narcotic users, non-English speakers or anyone previously enrolled.
What is being tested?
The study is looking at how fentanyl and morphine affect the way aspirin works on platelets in patients with chest pain. Researchers want to see if fentanyl might be a better option than morphine because of potential negative effects associated with morphine.
What are the potential side effects?
Possible side effects from fentanyl or morphine can include nausea, vomiting, constipation, drowsiness, confusion, respiratory depression (slow breathing), and addiction potential.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I took aspirin within 30 minutes before my first blood test.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I am currently taking aspirin, clopidogrel, or stronger blood thinners.
Select...
I cannot give consent in English.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 hours for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
platelet aggregation

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: MorphineExperimental Treatment1 Intervention
the second group will be those receiving morphine
Group II: FentanylExperimental Treatment1 Intervention
the 3rd group will be those receiving fentanyl
Group III: ControlActive Control1 Intervention
not receiving any narcotics
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Morphine
2013
Completed Phase 4
~2230
Fentanyl
2019
Completed Phase 4
~1920

Find a Location

Who is running the clinical trial?

Spectrum Health - LakelandLead Sponsor
13 Previous Clinical Trials
1,184 Total Patients Enrolled
~18 spots leftby Jul 2025
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