Procedure
Deep Brain Stimulation for Opioid Addiction
This trial is testing a device that sends electrical signals to the brain to help people with severe opioid addiction who haven't been helped by other treatments. The device aims to control brain areas involved in addiction and behavior. Current experimental evidence indicates that this method has excellent potential to help with treatment, showing fewer side effects and better adherence.
Behavioral Intervention
Harm Reduction Kiosk for Substance Use-Related Health Risks
This trial will test a new harm reduction kiosk called KyOSK in rural Appalachia to help people who use drugs stay safer. The kiosk provides clean needles and other supplies to reduce the risk of HIV, hepatitis C, and overdoses. The study aims to determine if this new approach is more effective and cost-efficient.
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Trials for Opioid Use Disorder Patients
Behavioural Intervention
Smartphone Apps for Opioid Use Disorder
This trial would use apps to help prevent relapse among patients receiving treatment for opioid use disorder. The apps would track the person's location and offer targeted, personalized intervention when they enter an area at high risk for relapse.
Behavioural Intervention
CBD for Opioid Use Disorder
This trial will test if CBD can help reduce craving and anxiety in people abstaining from heroin. Brain scans will be taken before and after CBD administration to see how it affects neural circuits and transmitters.
Learning Health System Intervention for Substance Use Disorders
This trial seeks to address the national addiction crisis at its epicenter by creating alliances between the juvenile justice system and community mental health centers to disseminate addiction prevention and treatment.
Neuromodulator Medical Device
Bridge Device + Lofexidine for Opioid Use Disorder
This trial is testing a device called the Bridge Device, which uses electrical signals to help people with opioid addiction. The study focuses on individuals who are not currently on any medication for their addiction. The device aims to ease withdrawal symptoms by sending signals to the brain. Participants will be monitored to see if the device effectively reduces withdrawal symptoms.
Trials for OUD Patients
Behavioural Intervention
Smartphone Apps for Opioid Use Disorder
This trial would use apps to help prevent relapse among patients receiving treatment for opioid use disorder. The apps would track the person's location and offer targeted, personalized intervention when they enter an area at high risk for relapse.
Behavioural Intervention
CBD for Opioid Use Disorder
This trial will test if CBD can help reduce craving and anxiety in people abstaining from heroin. Brain scans will be taken before and after CBD administration to see how it affects neural circuits and transmitters.
Learning Health System Intervention for Substance Use Disorders
This trial seeks to address the national addiction crisis at its epicenter by creating alliances between the juvenile justice system and community mental health centers to disseminate addiction prevention and treatment.
Neuromodulator Medical Device
Bridge Device + Lofexidine for Opioid Use Disorder
This trial is testing a device called the Bridge Device, which uses electrical signals to help people with opioid addiction. The study focuses on individuals who are not currently on any medication for their addiction. The device aims to ease withdrawal symptoms by sending signals to the brain. Participants will be monitored to see if the device effectively reduces withdrawal symptoms.
Phase 3 Trials
Neuromodulator Medical Device
Bridge Device + Lofexidine for Opioid Use Disorder
This trial is testing a device called the Bridge Device, which uses electrical signals to help people with opioid addiction. The study focuses on individuals who are not currently on any medication for their addiction. The device aims to ease withdrawal symptoms by sending signals to the brain. Participants will be monitored to see if the device effectively reduces withdrawal symptoms.
Opioid Agonist
Buprenorphine for Opioid Addiction during Pregnancy
This trial is testing whether an extended-release form of buprenorphine is as effective as the standard form in treating pregnant women with opioid use disorder, with the goal of improving outcomes for mother and child.
Opioid Agonist
Extended-release vs Sublingual Buprenorphine for Opioid Use Disorder
This trial will explore how well an extended-release injectable medication helps people with opioid use disorder in rural areas. It will compare it to a standard medication. Results will include patient outcomes.
Opioid Antagonist
Long-acting Naltrexone for Opioid Addiction
This trial tests if giving long-lasting naltrexone injections at home can help pre-release prisoners with opioid use disorders stick to their treatment. Naltrexone works by blocking the effects of opioids, making them less appealing. A long-lasting version of naltrexone has been developed and approved in the USA and Russia.
Trials With No Placebo
Behavioural Intervention
Smartphone Apps for Opioid Use Disorder
This trial would use apps to help prevent relapse among patients receiving treatment for opioid use disorder. The apps would track the person's location and offer targeted, personalized intervention when they enter an area at high risk for relapse.
Learning Health System Intervention for Substance Use Disorders
This trial seeks to address the national addiction crisis at its epicenter by creating alliances between the juvenile justice system and community mental health centers to disseminate addiction prevention and treatment.
Opioid Agonist
Buprenorphine for Opioid Addiction during Pregnancy
This trial is testing whether an extended-release form of buprenorphine is as effective as the standard form in treating pregnant women with opioid use disorder, with the goal of improving outcomes for mother and child.
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Frequently Asked Questions
Introduction to opioid dependence
What are the top hospitals conducting opioid dependence research?
In the battle against opioid dependence, several hospitals have emerged as leaders in conducting clinical trials to find effective treatments and interventions. Leading the way is Boston Medical Center in Boston with its five ongoing trials dedicated to tackling this pervasive issue. With a total of 11 trials on record since their first recorded trial in 2009, this hospital has been at the forefront of addressing opioid dependence for over a decade. Massachusetts General Hospital, also located in Boston, plays an integral role with four active trials and five completed studies focused on opioid dependence since their inaugural trial in 2021.
Meanwhile, down south at the Medical University of South carolina in Charleston, researchers are actively engaged in four ongoing clinical trials targeting opioid dependence. Having conducted nine trials overall since embarking on their first one back in 2017, this institution is making significant strides towards combatting this crisis from a different geographic standpoint.
Gateway Community Services located in Jacksonville contributes to these efforts through its three active opioid dependence trials and a history of four previously conducted studies that began back when they initiated their first trial just last year—showing dedication even amidst challenges faced by relatively smaller-scale institutions within this field.
Notably joining forces with Massachusetts General Hospital is their HOPE Clinic—a specialized center solely focusing on providing assistance for those grappling with addiction issues—including opioids—with three ongoing clinical tests currently underway alongside marking off completion of additional trio experiments all being documented starting from early beginnings recorded recently during2020
These top hospitals work collaboratively towards finding solutions that can alleviate the burden faced by individuals dealing with opioid dependence while striving to reduce addiction rates nationwide. Their collective efforts pave the way for innovative approaches and cutting-edge therapies that offer hope not only for patients but for communities impacted by this critical public health concern
Which are the best cities for opioid dependence clinical trials?
Boston, Massachusetts is widely recognized as one of the best cities for opioid dependence clinical trials. With 20 active trials underway, Boston's research focuses on a variety of treatments including Buprenorphine Injection, Psilocybin, and Post-discharge Pain management Follow-up. Additionally, New york City boasts 16 ongoing trials that explore interventions such as Pain Coping Skills Training and Buprenorphine. Baltimore, Maryland also stands out with its 13 active trials studying Intervention Arm, Bridge Device, and Ketamine Hydrochloride. These cities provide individuals struggling with opioid dependence access to cutting-edge clinical trials that may offer new hope in combating this epidemic.
Which are the top treatments for opioid dependence being explored in clinical trials?
Clinical trials are at the forefront of exploring effective treatments for opioid dependence. Promising options include:
- Buprenorphine Injection: Currently being tested in three active trials, with a total of three all-time trials dedicated to opioid dependence since its introduction in 2020.
- Psilocybin: Showing potential, psilocybin is currently being investigated in one active trial and has been included in three all-time clinical trials focused on opioid dependence since its listing in 2023. These innovative approaches hold hope for improving outcomes and offering new paths towards overcoming opioid addiction.
What are the most recent clinical trials for opioid dependence?
Recent clinical trials for opioid dependence offer promising solutions to help individuals overcome this challenging condition. The Aurora 1:1 Drops (Indica) trial, in its Phase 2 stage, explores the potential of a specific medication in addressing opioid dependence. Additionally, the Empowered Relief On Demand trial has entered Phase 3 and shows great potential as an effective treatment option. Another study, known as the Bridge Induction Arm trial, also in Phase 3, investigates innovative approaches to managing opioid dependence. Moreover, utilizing smartphones as a resource for support is being examined through a Phase 2 trial. Lastly, the Personalized Prescription Group (POP) aims to optimize treatment outcomes by tailoring prescriptions specifically for patients with opioid dependence during their Phase 4 investigation. These groundbreaking trials hold promise for improving lives affected by opioid dependence and paving the way towards more effective treatments.
What opioid dependence clinical trials were recently completed?
Several clinical trials focusing on opioid dependence have recently concluded, showcasing advancements in treatment options. In August 2022, Indivior Inc. successfully completed a trial investigating the potential of INDV-2000 to address this challenging condition. Additionally, BioCorRx Pharmaceuticals brought their BICX104 study to fruition in June 2022, while Go Medical Industries Pty Ltd concluded their trial on Naltrexone 380 MG in January 2021. These recent developments underscore ongoing efforts by researchers and pharmaceutical companies to combat opioid dependence and provide hope for individuals grappling with addiction.