Photodynamic Therapy + Immunotherapy for Non-Small Cell Lung Cancer

Recruiting in Palo Alto (17 mi)

Overseen by• Saikrishna Yendamuri, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 1

Waitlist Available

Sponsor: Roswell Park Cancer Institute

No Placebo Group

Trial Summary

What is the purpose of this trial?This phase I trial evaluates the side effects of intraoperative photodynamic therapy with porfimer sodium in enhancing the response to immunotherapy with an immune checkpoint inhibitor drug in patients with non-small cell lung cancer with pleural disease. Photodynamic therapy is a technique that that works by combining a photosensitizing agent (porfimer sodium in this trial) and an intense light source to kill tumor cells. Photodynamic therapy may decrease the patients' symptoms and improve their quality of life.

Eligibility Criteria

This trial is for adults with non-small cell lung cancer and pleural disease who are on or eligible for standard immunotherapy, have a life expectancy of at least 12 weeks, and can consent to the study. They must not have had recent chemotherapy or unresolved side effects from previous treatments. Pregnant or nursing individuals and those with certain autoimmune disorders or unstable health conditions cannot participate.

Inclusion Criteria

I am on immunotherapy or chemo and immunotherapy without my cancer getting worse.

My lung cancer involves the pleura and has low PDL1 levels, or I have mesothelioma not suitable for complete surgical removal.

I can carry out all my usual activities without help.

+5 more

Exclusion Criteria

I do not have any severe illnesses or social situations that would stop me from following the study's requirements.

I am currently pregnant or breastfeeding.

I haven't had chemotherapy or radiation in the last 4-6 weeks and have recovered from any side effects.

+7 more

Participant Groups

The trial tests intraoperative photodynamic therapy (PDT) using porfimer sodium alongside standard immunotherapy in patients. PDT aims to kill tumor cells by combining a light-sensitive drug with light exposure, potentially improving symptoms and quality of life.

1Treatment groups

Experimental Treatment

Group I: Treatment (porfimer sodium, photodynamic therapy)Experimental Treatment4 Interventions

Patients receive porfimer sodium IV over 3-5 minutes 24-48 hours prior to standard of care VATS, followed by photodynamic therapy