← Back to Search

Lidocaine for Glioblastoma

Phase 1

Waitlist Available

Led By Kiarash Shahlaie

Research Sponsored by Kiarash Shahlaie, M.D., Ph.D.

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 30 says after surgery

Awards & highlights

No Placebo-Only Group

Summary

This trial studies the effects of injecting lidocaine into patients with glioblastoma during their brain tumor surgery. Lidocaine helps to relieve pain by blocking nerve signals. Researchers hope this will lead to better treatments for glioblastoma in the future. Lidocaine has been used for pain relief in various medical contexts, including surgery and cancer treatment.

Eligible Conditions

Glioblastoma
Brain Tumor

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 30 says after surgery

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 30 says after surgery

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 30 says after surgery for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Difference between the concentrations of lidocaine in the tumor tissue and in the blood (baseline level)

Secondary study objectives

Incidence of adverse events (AEs)

Overall survival (OS)

Progression free survival (PFS)

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Health services research (lidocaine, surgery)Experimental Treatment3 Interventions

Patients receive bolus lidocaine IV per standard of care. After intubation, patients receive another infusion of lidocaine IV over 4 hours or until the end of surgery. Patients also undergo collection of blood and tumor samples at the start of surgery and hourly afterwards until a total of 4 samples are collected.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Biospecimen Collection

2004

Completed Phase 3

~2020

Lidocaine

2011

Completed Phase 4

~1370