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A Study of Effect of LY3556050 on Metformin in Healthy Participants

Phase 1
Waitlist Available
Research Sponsored by Eli Lilly and Company
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up predose on day 1 through 13 days postdose
Awards & highlights
No Placebo-Only Group

Summary

This trial tests how a diabetes medication (Metformin) works with another drug (LY3556050) in healthy people. It also checks kidney function using a special dye (Iohexol). Metformin is a widely used diabetes medication that reduces vascular risk and does not increase body weight, with a lower risk of severe lactic acidosis compared to its predecessor, phenformin.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~predose on day 1 through 13 days postdose
This trial's timeline: 3 weeks for screening, Varies for treatment, and predose on day 1 through 13 days postdose for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Metformin
Metformin

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: LY3556050 + Metformin + IohexolExperimental Treatment3 Interventions
LY3556050 administered orally in combination with metformin given orally and iohexol given intravenously (IV).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
LY3556050
2021
Completed Phase 2
~520
Metformin
2006
Completed Phase 4
~2430
Iohexol
2016
Completed Phase 4
~1970

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Eli Lilly and CompanyLead Sponsor
2,680 Previous Clinical Trials
3,466,366 Total Patients Enrolled
Study DirectorEli Lilly and Company
1,391 Previous Clinical Trials
428,823 Total Patients Enrolled
~6 spots leftby Dec 2025
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