← Back to Search

Local Anesthetic

Peripheral Nerve Block (PNB) group for Postoperative Pain

Phase 2
Waitlist Available
Led By Philip Wilson, MD
Research Sponsored by Texas Scottish Rite Hospital for Children
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* 10+ years old
* Presenting with an injury that requires an ACL reconstruction with a bone-patellar tendon-bone or quadriceps tendon graft
Timeline
Screening 3 weeks
Treatment Varies
Follow Up preoperatively and within one week postoperatively.
Awards & highlights

Summary

The goal of this randomized clinical trial is to determine if single-shot ropivacaine peripheral nerve blocks (PNB - perineural injections) for anterior cruciate ligament (ACL) reconstruction procedures in pediatric orthopaedic sports medicine patients provides significant pain relief and decreased narcotic use. The main questions it aims to answer are: * Does ropivacaine significantly reduce Visual Analog Scale (VAS) pain scores and pain levels up to one week postoperatively? * Does ropivacaine significantly decrease narcotic use (number of pills taken) up to one week postoperatively? Researchers will compare the pain outcomes and narcotic use of participants who receive a single-shot ropivacaine peripheral nerve block to those of participants who do not receive a single-shot ropivacaine peripheral nerve block for their ACL reconstruction surgery. The goal is to understand if there is a significant difference in participant pain outcomes and narcotic use outside the first 24 hours postoperatively. Participants will: * receive either a single-shot ropivacaine peripheral nerve block intraoperatively or no peripheral nerve block during their ACL Quadriceps tendon graft or bone patellar tendon bone graft reconstruction surgery. * receive and complete questionnaires at postoperative days 1, 4, and 7 regarding their pain scores, levels, and outcomes, effective pain treatments, overall pain interference, narcotic use (number of pills taken), and overall pain treatment satisfaction * receive and complete secondary outcome measures of functional and psychological outcomes regarding their ACL reconstruction surgery at postoperative day 1

Who is the study for?
This trial is for pediatric patients undergoing ACL reconstruction surgery. It's designed to see if a single-shot nerve block with ropivacaine can help manage pain after the operation and reduce the need for narcotics.
What is being tested?
Researchers are testing whether a one-time injection of ropivacaine, given during surgery, can lower pain levels and decrease narcotic use post-surgery compared to not using the nerve block. Participants will report their pain and medication use over a week.
What are the potential side effects?
Ropivacaine may cause side effects such as weakness or numbness near the injection site, nausea, low blood pressure, or an allergic reaction. However, it's generally considered safe with proper medical supervision.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~postoperative days 1, 4, and 7
This trial's timeline: 3 weeks for screening, Varies for treatment, and postoperative days 1, 4, and 7 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Pain Management Patient Satisfaction questionnaire
Scottish Rite for Children-developed pain questionnaire
Visual Analog Scale (VAS) 10-centimeter line 0-10 Numeric Pain Intensity Scale
+1 more
Secondary study objectives
Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Scale v1.0 - Global Health 7+2

Trial Design

2Treatment groups
Active Control
Group I: Peripheral Nerve Block (PNB) groupActive Control1 Intervention
* Patients will receive a purple surgical marker dot at the decided site of injection * A 20 mL Adductor PNB will be injected intraoperatively at the point of the purple dot * Patient will receive 0.2% plain Ropivacaine (perineural injection) regardless of weight
Group II: No Peripheral Nerve Block (PNB) groupActive Control1 Intervention
* Patients will receive a purple surgical marker dot at a point where a PNB would be injected, if they were randomized to the no peripheral nerve block group * A bandage will be placed over the purple dot and wrapped with the standard gauze/bandage from the surgery

Find a Location

Who is running the clinical trial?

Texas Scottish Rite Hospital for ChildrenLead Sponsor
20 Previous Clinical Trials
8,938 Total Patients Enrolled
Philip Wilson, MDPrincipal InvestigatorTexas Scottish Rite Hospital for Children
1 Previous Clinical Trials
100 Total Patients Enrolled
~107 spots leftby Dec 2026