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Antimetabolite

Rapamycin in With High-Dose Etoposide and Cytarabine in Relapsed/Refractory Aggressive Lymphoid Malignancies (UPCC 25406 Trial)

Phase 1 & 2
Waitlist Available
Led By Selina Luger, MD
Research Sponsored by Abramson Cancer Center of the University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group
All Individual Drugs Already Approved
Approved for 5 Other Conditions

Summary

Assess the safety, tolerability and efficacy of rapamycin in combination with HiVAC in relapsed and refractory patients with aggressive lymphoid malignancies.

Eligible Conditions
  • Chronic Myeloid Leukemia
  • Acute Lymphoblastic Leukemia
  • Burkitt Lymphoma
  • Lymphoblastic Leukemia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 5 Other Conditions
This treatment demonstrated efficacy for 5 other conditions.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Arm 1Experimental Treatment1 Intervention
Rapamycin in combination with High Dose Etoposide and Cytarabine (HiVAC)

Find a Location

Who is running the clinical trial?

Abramson Cancer Center of the University of PennsylvaniaLead Sponsor
359 Previous Clinical Trials
108,351 Total Patients Enrolled
Abramson Cancer Center at Penn MedicineLead Sponsor
418 Previous Clinical Trials
464,118 Total Patients Enrolled
Selina Luger, MDPrincipal InvestigatorUniversity of Pennsylvania Abramson Cancer Center
1 Previous Clinical Trials
13 Total Patients Enrolled
~0 spots leftby Dec 2025
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