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Exercise-Induced Kidney Blood Flow Response in African American Adults
N/A
Recruiting
Led By Rachel C Drew, PhD
Research Sponsored by University of Massachusetts, Boston
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be between 18 and 65 years old
Must not have
Females who are pregnant or lactating
Obesity (body mass index of more than or equal to 30 kg/m2)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up pre-acute exercise and during steady-state exercise
Awards & highlights
No Placebo-Only Group
Summary
This trial will study the renal vasoconstrictor response to sympathetic stressors in healthy African American adults prior to development of cardiovascular and renal disease to test the hypotheses that the renal vasoconstrictor response to acute dynamic exercise, as well as a cold pressor and mental stress tests, is exaggerated in healthy young African American adults compared to white adults.
Who is the study for?
This trial is for African American and White adults born in the U.S., fluent in English, who are active but not training competitively. Participants must have parents of the same racial identity. It excludes pregnant or lactating women, those with hypertension, diabetes, obesity, smokers, or anyone with cardiovascular/renal disease.
What is being tested?
The study investigates how acute exercise and stress tests (cold pressor test and mental stress test) affect kidney blood flow in healthy African American adults compared to Whites. The goal is to understand if there's an exaggerated response that could contribute to higher rates of cardiovascular and renal diseases.
What are the potential side effects?
Since this trial involves non-drug interventions like exercise and stress tests rather than medications, side effects may include temporary discomfort from cold exposure during the cold pressor test or increased heart rate and blood pressure due to exercise or mental stress.
Eligibility Criteria
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I am not pregnant or breastfeeding.
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My BMI is 30 or higher.
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My blood pressure is 130/80 mmHg or higher.
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I have diabetes.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change in renal vascular resistance during acute exercise
Change in renal vascular resistance during cold pressor test
Change in renal vascular resistance during mental stress test
Secondary study objectives
Change in cardiac output during acute exercise
Change in cardiac output during cold pressor test
Change in cardiac output during mental stress test
+21 moreOther study objectives
Rating of cold perception during cold pressor test
Rating of hand pain during cold pressor test
Rating of perceived exertion during acute exercise
+1 moreAwards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
2Treatment groups
Experimental Treatment
Group I: White AdultsExperimental Treatment3 Interventions
White adults will undergo the interventions of acute exercise, a cold pressor test, and a mental stress test while beat-to-beat renal blood flow velocity, mean arterial blood pressure, and heart rate are recorded.
Group II: African American AdultsExperimental Treatment3 Interventions
African American adults will undergo the interventions of acute exercise, a cold pressor test, and a mental stress test while beat-to-beat renal blood flow velocity, mean arterial blood pressure, and heart rate are recorded.
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Who is running the clinical trial?
University of Massachusetts, BostonLead Sponsor
36 Previous Clinical Trials
15,746 Total Patients Enrolled
Rachel C Drew, PhDPrincipal InvestigatorUniversity of Massachusetts, Boston
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Eligibility Criteria:
This trial includes the following eligibility criteria:- I have heart or kidney disease.You exercise regularly for at least 20 minutes per day, three times per week, but you are not a competitive athlete.You use tobacco or smoke cigarettes.I am not pregnant or breastfeeding.My BMI is 30 or higher.I am on prescribed medications, but not birth control pills.My blood pressure is 130/80 mmHg or higher.You have a serious medical condition that requires immediate treatment.You are a person of Hispanic or Latino ethnicity.I have diabetes.Both of your biological parents belong to the same racial identity as you.You identify as either African American or White.
Research Study Groups:
This trial has the following groups:- Group 1: African American Adults
- Group 2: White Adults
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.