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Fluoroquinolone Antibiotic

Ciprofloxacin vs Levofloxacin for Stem Cell Transplant Prophylaxis

Phase 2
Waitlist Available
Research Sponsored by Henry Ford Health System
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients 18-75 years of age with a diagnosis of a hematological malignancy.
Meet the stem cell transplant program criteria to undergo autologous or allogeneic hematopoietic stem cell transplantation.
Must not have
Prolonged QT
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 60 days post stem cell transplant
Awards & highlights
No Placebo-Only Group

Summary

This trialstudied 2 antibiotics for prophylaxis in stem cell transplants. Results suggest one may be better than the other, but more research is needed.

Who is the study for?
This trial is for adults aged 18-75 who are about to receive a stem cell transplant due to blood cancers and meet the specific program criteria. It's not open to those with allergies to ciprofloxacin or levofloxacin, or individuals with prolonged QT interval, which is an abnormality seen on heart tests.
What is being tested?
The study compares two antibiotics: Ciprofloxacin and Levofloxacin, used as preventive treatments in patients undergoing stem cell transplants. The goal is to determine which one better prevents infections without causing significant complications.
What are the potential side effects?
Possible side effects of both antibiotics include digestive issues like nausea and diarrhea, potential allergic reactions, nerve damage that can cause pain or weakness, and changes in heartbeat rhythm.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 75 years old and have been diagnosed with a blood cancer.
Select...
I am eligible for a stem cell transplant according to the program's criteria.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have a long QT interval on my ECG.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~60 days post stem cell transplant
This trial's timeline: 3 weeks for screening, Varies for treatment, and 60 days post stem cell transplant for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Sepsis

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: LevoExperimental Treatment1 Intervention
Levofloxacin 500 mg once daily
Group II: CiproActive Control1 Intervention
Ciprofloxacin 500 mg BID
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Levofloxacin
2011
Completed Phase 4
~8180

Find a Location

Who is running the clinical trial?

Henry Ford Health SystemLead Sponsor
311 Previous Clinical Trials
2,176,058 Total Patients Enrolled
1 Trials studying Stem Cell Transplant Complications
255 Patients Enrolled for Stem Cell Transplant Complications

Media Library

Ciprofloxacin (Fluoroquinolone Antibiotic) Clinical Trial Eligibility Overview. Trial Name: NCT03850379 — Phase 2
Stem Cell Transplant Complications Research Study Groups: Levo, Cipro
Stem Cell Transplant Complications Clinical Trial 2023: Ciprofloxacin Highlights & Side Effects. Trial Name: NCT03850379 — Phase 2
Ciprofloxacin (Fluoroquinolone Antibiotic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03850379 — Phase 2
~40 spots leftby Nov 2025
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