Prazosin for Agitation in Alzheimer's Disease
Recruiting in Palo Alto (17 mi)
+12 other locations
Overseen ByHoward Feldman
Age: Any Age
Sex: Any
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: Phase 2
Waitlist Available
Sponsor: Alzheimer's Disease Cooperative Study (ADCS)
Prior Safety Data
Trial Summary
What is the purpose of this trial?The study evaluates the effects of Prazosin on agitation in adults with Alzheimer's disease.
Two thirds of the participants will participate in the medication portion, while one third will participate in the placebo portion
Eligibility Criteria
Participant Groups
2Treatment groups
Active Control
Placebo Group
Group I: Treatment (Prazosin)Active Control1 Intervention
Eligible participants will be randomized using a 2:1 schedule to prazosin or placebo and stratified by site and gender, and will follow a fixed titration scheme for the first 15 days, followed by a flexible does titration from days 15-29, then a maintenance phase stable dose from days 29 to the end of the 12 weeks study period.
Prazosin Fixed titration dose schedule for Days 1 to 14 1 mg QHS for Days 1 to 3
1 mg QAM and 1 mg QHS for days 4 to 7
1. mg QAM and 2 mg QHS for days 8 to 10
2. mg QAM and 2 mg QHS for days 11 to 14
Prazosin Flexible titration dose schedule for Days 15 to 29. 3 mg QAM and 3 mg QHS on day 15, 4 mg QAM and 4 mg QHS on day 22, 4 mg QAH and 6 mg QHS on day 29,
Dose increases will be allowed only during the fixed and flexible dosing periods.
Group II: Placebo oral capsulePlacebo Group1 Intervention
Placebo medication will be administered in a titration schedule mimicking the active comparator treatment.
Find A Clinic Near You
Research locations nearbySelect from list below to view details:
VAMC: James J PetersBronx, NY
Oregon Health and Science UniversityPortland, OR
Roper St. Francis HospitalCharleston, SC
SUNY Upstate Medical UniversitySyracuse, NY
More Trial Locations
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Who is running the clinical trial?
Alzheimer's Disease Cooperative Study (ADCS)Lead Sponsor
VA Puget Sound Health Care SystemCollaborator
Alzheimer's AssociationCollaborator
National Institute on Aging (NIA)Collaborator