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Biological Response Modifier

Atacicept Dose for Lupus Nephritis (COMPASS Trial)

Phase 3
Waitlist Available
Research Sponsored by Vera Therapeutics, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Pivotal Trial

Summary

This trial will look at how a drug affects kidney function in people with Lupus Nephritis.

Eligible Conditions
  • Lupus Nephritis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Side effects data

From 2009 Phase 2 trial • 256 Patients • NCT00430495
18%
Headache
8%
Nausea
6%
Urinary tract infection
6%
Diarrhoea
6%
Constipation
5%
Nasopharyngitis
5%
Hypertension
5%
Upper respiratory tract infection
3%
Rheumatoid arthritis
2%
Pyrexia
2%
Femur fracture
2%
Fibrin D dimer increased
2%
Drug hypersensitivity
2%
Hyperthyroidism
2%
Anaemia
2%
Relapsing fever
2%
Non-cardiac chest pain
2%
Fallopian tube cyst
2%
Gamma-glutamyltransferase increased
2%
Iron deficiency anaemia
2%
Humerus fracture
2%
Pelvic fracture
2%
Upper limb fracture
2%
Diverticular perforation
2%
Intestinal obstruction
100%
80%
60%
40%
20%
0%
Study treatment Arm
Atacicept 25 mg
Placebo
Atacicept 75 mg
Atacicept 150 mg

Awards & Highlights

Pivotal Trial
The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Atacicept DoseExperimental Treatment1 Intervention
Atacicept Dose once weekly subcutaneous (SC) Injection
Group II: Placebo to match AtaciceptPlacebo Group1 Intervention
Placebo to match Atacicept once weekly subcutaneous (SC) injection
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Atacicept
2006
Completed Phase 2
~600

Find a Location

Who is running the clinical trial?

Vera Therapeutics, Inc.Lead Sponsor
3 Previous Clinical Trials
882 Total Patients Enrolled
Joanne CurleyStudy DirectorChief Development Officer
1 Previous Clinical Trials
376 Total Patients Enrolled
~135 spots leftby Mar 2026
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