~104 spots leftby Feb 2026

Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men

Palo Alto (17 mi)
Overseen byAnne Luetkemeyer, MD
Age: 18+
Sex: Male
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: Phase 4
Waitlist Available
Sponsor: University of California, San Francisco
No Placebo Group
Prior Safety Data

Trial Summary

What is the purpose of this trial?This trial is testing if taking a doxycycline pill after unprotected sex can prevent STIs like gonorrhea, chlamydia, and syphilis. The study focuses on men who have sex with men, including those with HIV and those on PrEP. Doxycycline works by killing or stopping the bacteria that cause these infections. Doxycycline has been used for the prevention of syphilis and other sexually transmitted infections, with studies showing high efficacy.

Eligibility Criteria

Treatment Details

2Treatment groups
Experimental Treatment
Active Control
Group I: Doxy PEPExperimental Treatment1 Intervention
Doxycycline 200mg in addition to standard of care STI testing and treatment
Group II: ControlActive Control1 Intervention
The control arm will consist of standard of care STI testing and treatment

Find a clinic near you

Research locations nearbySelect from list below to view details:
University of California, San Francisco / Zuckerberg San Francisco General Hospital/UCSFSan Francisco, CA
University of WashingtonSeattle, WA
San Francisco City Clinic / San Francisco Department of Public HealthSan Francisco, CA
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Who is running the clinical trial?

University of California, San FranciscoLead Sponsor
San Francisco Department of Public HealthCollaborator
University of WashingtonCollaborator
National Institute of Allergy and Infectious Diseases (NIAID)Collaborator
Mayne Pharma International Pty LtdIndustry Sponsor

References