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Noninvasive Brain Stimulation

Individualized tDCS for Motor Function Improvement

N/A
Recruiting
Led By Mark S George, MD
Research Sponsored by Medical University of South Carolina
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
No history of epilepsy
Be older than 18 years old
Must not have
History of epilepsy or claustrophobia
Current treatment for any psychiatric conditions (pharmacological or otherwise)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and post-stimulation (20 minutes apart)

Summary

This trial will test whether a method of individually tailoring transcranial direct current stimulation (tDCS) can help to improve the stimulation's effects on behavior.

Who is the study for?
This trial is for right-handed individuals with no metal in their body, who can undergo TMS or MRI scans and have no history of epilepsy. It's open to healthy volunteers as well as those who had a stroke at least 6 months ago. Pregnant or breastfeeding individuals, those with substance abuse issues, current psychiatric treatments, or claustrophobia cannot participate.
What is being tested?
The study tests different doses of transcranial direct current stimulation (tDCS) on brain activity: standard doses (2mA and 4mA), a sham dose that mimics tDCS without real effects, and an individualized dose tailored to the participant's response to potentially enhance motor function.
What are the potential side effects?
tDCS may cause mild side effects such as tingling, itching or discomfort at the electrode site, fatigue, headache, nausea or dizziness. These are typically short-lived and vary from person to person.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have never had epilepsy.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have a history of epilepsy or claustrophobia.
Select...
I am currently receiving treatment for a mental health condition.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and post-stimulation (20 minutes apart)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and post-stimulation (20 minutes apart) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in Motor Evoked Potential Variance
Difference in Motor Evoked Potential Amplitudes from 4mA and 2mA Stimulation

Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: Individualized stimulationExperimental Treatment1 Intervention
Group II: 4mA stimulationExperimental Treatment1 Intervention
Group III: 2mA stimulationExperimental Treatment1 Intervention
Group IV: Sham stimulationPlacebo Group1 Intervention

Find a Location

Who is running the clinical trial?

Medical University of South CarolinaLead Sponsor
974 Previous Clinical Trials
7,399,337 Total Patients Enrolled
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)NIH
2,056 Previous Clinical Trials
2,738,074 Total Patients Enrolled
Mark S George, MDPrincipal InvestigatorMedical University of South Carolina
4 Previous Clinical Trials
137 Total Patients Enrolled

Media Library

2mA transcranial direct current stimulation (Noninvasive Brain Stimulation) Clinical Trial Eligibility Overview. Trial Name: NCT04742439 — N/A
Transcranial Direct Current Stimulation Research Study Groups: 4mA stimulation, Sham stimulation, Individualized stimulation, 2mA stimulation
Transcranial Direct Current Stimulation Clinical Trial 2023: 2mA transcranial direct current stimulation Highlights & Side Effects. Trial Name: NCT04742439 — N/A
2mA transcranial direct current stimulation (Noninvasive Brain Stimulation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04742439 — N/A
~47 spots leftby Dec 2025
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