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Brain Stimulation for Speech Motor Learning
N/A
Recruiting
Led By David Ostry
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
no known physical or neurological abnormalities
Be between 18 and 65 years old
Must not have
currently taking antianxiety drugs
history of concussion
Timeline
Screening 3 weeks
Treatment Varies
Follow Up single day experiment
Awards & highlights
No Placebo-Only Group
Summary
This trial will study whether suppressing activity in a certain area of the brain affects a person's ability to learn.
Who is the study for?
This trial is for right-handed adults with no known physical or neurological abnormalities. It's not suitable for those with metal in their body, claustrophobia, on antipsychotic/antidepressant/antianxiety drugs, pregnant women, anyone with heart clips or implants, a history of concussion or epilepsy.
What is being tested?
The study tests how suppressing activity in part of the brain (Brodmann area 46v) using cTBS affects learning speech movements and sounds. The focus is on understanding memory's role in speech motor learning.
What are the potential side effects?
cTBS may cause discomfort at the stimulation site, mild headaches or lightheadedness post-treatment. There could be temporary changes to skin sensation or twitching during application.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I do not have any known physical or neurological abnormalities.
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I am currently on medication for anxiety.
Select...
I have had a concussion before.
Select...
I am currently on antidepressant medication.
Select...
I am currently on antipsychotic medication.
Select...
I have surgical clips or valves in my heart.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ performance as measured at the end of learning (single day experiment)
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~performance as measured at the end of learning (single day experiment)
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Sensory Memory
Speech Motor Learning
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
5Treatment groups
Experimental Treatment
Group I: Somatosensory Sensory MemoryExperimental Treatment1 Intervention
Somatosensory Sensory Memory
Group II: Sensory Memory + cTBS to 46vExperimental Treatment2 Interventions
Sensory Memory + cTBS to 46v
Group III: Auditory Sensory MemoryExperimental Treatment1 Intervention
Auditory Sensory Memory
Group IV: Adaptation to Altered Auditory Feedback + cTBS to 46vExperimental Treatment2 Interventions
Adaptation to Altered Auditory Feedback + cTBS to 46v
Group V: Adaptation to Altered Auditory FeedbackExperimental Treatment1 Intervention
Adaptation to Altered Auditory Feedback
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Who is running the clinical trial?
Yale UniversityLead Sponsor
1,924 Previous Clinical Trials
3,031,538 Total Patients Enrolled
6 Trials studying Speech
980 Patients Enrolled for Speech
National Institute on Deafness and Other Communication Disorders (NIDCD)NIH
353 Previous Clinical Trials
181,357 Total Patients Enrolled
15 Trials studying Speech
1,931 Patients Enrolled for Speech
David OstryPrincipal InvestigatorHaskins Laboratories
6 Previous Clinical Trials
980 Total Patients Enrolled
6 Trials studying Speech
980 Patients Enrolled for Speech
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Eligibility Criteria:
This trial includes the following eligibility criteria:- I do not have any known physical or neurological abnormalities.You or a family member have a history of epilepsy.I am currently on medication for anxiety.I have had a concussion before.I am currently on antidepressant medication.You are afraid of small enclosed spaces.I am currently on antipsychotic medication.You are pregnant.You have implants in your body.I am right-handed.I have surgical clips or valves in my heart.I am a patient.You have a heart pacemaker.
Research Study Groups:
This trial has the following groups:- Group 1: Adaptation to Altered Auditory Feedback + cTBS to 46v
- Group 2: Adaptation to Altered Auditory Feedback
- Group 3: Auditory Sensory Memory
- Group 4: Somatosensory Sensory Memory
- Group 5: Sensory Memory + cTBS to 46v
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
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